anti-Sphingomyelin phosphodiesterase 3, Neutral Membrane (Neutral Sphingomyelinase II) (SMPD3) Antibodies

Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine.

list all antibodies Gene Name GeneID UniProt
Anti-Mouse SMPD3 SMPD3 58994 Q9JJY3
Anti-Rat SMPD3 SMPD3 94338 O35049
Anti-Human SMPD3 SMPD3 55512 Q9NY59
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More Antibodies against Sphingomyelin phosphodiesterase 3, Neutral Membrane (Neutral Sphingomyelinase II) Interaction Partners

Mouse (Murine) Sphingomyelin phosphodiesterase 3, Neutral Membrane (Neutral Sphingomyelinase II) (SMPD3) interaction partners

  1. SMPD3 in the regulation of the protein vesicular secretory pathway may become a diagnostic target in the etiology of unknown forms of juvenile growth and developmental inhibition.

  2. Study provides evidence that Smpd3 expression in both chondrocytes and osteoblasts is required for normal endochondral bone development.

  3. these results highlight the role of nSMase2 in apoptosis evoked by nutrient starvation that could contribute to the delayed apoptosis of hypertrophic chondrocytes in the growth plate, and emphasize the antiapoptotic properties of HAS2 (show HAS2 Antibodies)

  4. nSMase2 activation is required for the development of infection-induced diaphragm calpain activation and muscle weakness.

  5. These results suggest that OTC (show OTC Antibodies) is a potent stimulant of nSMase-2 expression and that there may be unanticipated complications of OTC (show OTC Antibodies) supplementation.

  6. Src (show SRC Antibodies) and p38 mitogen-activated protein kinase (show MAPK14 Antibodies) activities are critical for regulating nSMase2 phosphorylation.

  7. Smpd3 was identified as a redox-sensitive enzyme, whose basal activity mediated changes in its oligomeric state.

  8. Data confirms a crucial pro-survival role for SMPD3 during embryonic development.

  9. Smpd3/nSMase2-ceramide-Akt (show AKT1 Antibodies) signaling axis negatively regulates BMP-induced chondrocyte maturation.

  10. The H2O2-induced src (show SRC Antibodies)/PDGFRbeta/SK1 (show SPHK1 Antibodies) signaling cascade was impaired in nSMase2-deficient fro/fro cells and was rescued by exogenous C2Cer that activated src (show SRC Antibodies)/PDGFRbeta/SK1 (show SPHK1 Antibodies).

Human Sphingomyelin phosphodiesterase 3, Neutral Membrane (Neutral Sphingomyelinase II) (SMPD3) interaction partners

  1. ATRA regulates nSMase2 transcriptionally through the retinoic acid receptor-alpha (show RARA Antibodies), but this is independent of previously identified transcriptional regulators of nSMase2 (Sp1 (show PSG1 Antibodies), Sp3 (show SP3 Antibodies), Runx2 (show RUNX2 Antibodies)) and is not through increased promoter activity.

  2. Overexpression of Smpd3 induced cytodifferentiation of HPDL (show HPDL Antibodies) cells, which could be suppressed by an inhibitor of its protein product, nSMase2. In addition,Smpd3 harboring a SNP (rs145616324) showed no activity and failed to induce cytodifferentiation of HPDL (show HPDL Antibodies) cells. Together, these findings suggest that Smpd3 plays an important role in the osteoblastic differentiation of HPDL (show HPDL Antibodies) cells.

  3. low oxLDL concentration triggers sprouting angiogenesis that involves ROS (show ROS1 Antibodies)-induced activation of the neutral sphingomyelinase-2/sphingosine kinase-1 (show SPHK1 Antibodies) pathway, and is effectively inhibited by GW4869.

  4. nSMase2 is a novel p53 (show TP53 Antibodies) target gene, regulated by the DNA damage pathway to induce cell growth arrest.

  5. These results suggest that OTC (show OTC Antibodies) is a potent stimulant of nSMase-2 expression and that there may be unanticipated complications of OTC (show OTC Antibodies) supplementation.

  6. nSMase2 involvement in cellular processes including inflammatory signaling, exosome generation, cell growth, and apoptosis, which in turn play important roles in pathologies such as cancer metastasis, Alzheimer's disease

  7. SMPD3 plays an important role in the release of microRNAs into extracellular spaces.

  8. The data shows that nSMase3 (show SMPD4 Antibodies) acts as a signaling nSMase (show SMPD2 Antibodies) in skeletal muscle that is essential for TNF (show TNF Antibodies)-stimulated oxidant activity.

  9. This is the first report on the critical role of ceramide generated by nSMase2 in stem cell ciliogenesis and differentiation.

  10. We found upregulation of specific sphingolipid enzymes, namely sphingomyelin synthase 1 (SMS1 (show SGMS1 Antibodies)), sphingomyelinase 3 (SMPD3), and glucosylceramide synthase (GCS (show UGCG Antibodies)) in the endometrium of endometriotic women.

Cow (Bovine) Sphingomyelin phosphodiesterase 3, Neutral Membrane (Neutral Sphingomyelinase II) (SMPD3) interaction partners

  1. This study establishes NSMase2 as a pivotal enzyme in the onset of endothelial endoplasmic reticulum stress-mediated vascular dysfunction.

Sphingomyelin phosphodiesterase 3, Neutral Membrane (Neutral Sphingomyelinase II) (SMPD3) Antigen Profile

Protein Summary

Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Acts as a regulator of postnatal development and participates in bone and dentin mineralization. Overexpression enhances cell death, suggesting that it may be involved in apoptosis control. May be involved in IL-1-beta-induced JNK activation in hepatocytes. May act as a mediator in transcriptional regulation of NOS2/iNOS via the NF- kappa-B activation under inflammatory conditions.

Gene names and symbols associated with SMPD3

  • sphingomyelin phosphodiesterase 3, neutral (Smpd3) antibody
  • sphingomyelin phosphodiesterase 3, neutral membrane (Smpd3) antibody
  • sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) (SMPD3) antibody
  • 4631433G07Rik antibody
  • AI427456 antibody
  • AW537966 antibody
  • cca1 antibody
  • fro antibody
  • NSMase2 antibody

Protein level used designations for SMPD3

nSMase-2 , neutral sphingomyelinase 2 , neutral sphingomyelinase II , sphingomyelin phosphodiesterase 3 , confluent 3Y1 cell-associated 1 , confluent 3Y1 cell-associated protein 1 , nSMase2 , neutral sphingomyelin phosphodiesterase 3

GENE ID SPECIES
58994 Mus musculus
94338 Rattus norvegicus
55512 Homo sapiens
489743 Canis lupus familiaris
514201 Bos taurus
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