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Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine.
these results highlight the role of nSMase2 in apoptosis evoked by nutrient starvation that could contribute to the delayed apoptosis of hypertrophic chondrocytes in the growth plate, and emphasize the antiapoptotic properties of HAS2 (show HAS2 Proteins)
nSMase2 activation is required for the development of infection-induced diaphragm calpain activation and muscle weakness.
These results suggest that OTC (show OTC Proteins) is a potent stimulant of nSMase-2 expression and that there may be unanticipated complications of OTC (show OTC Proteins) supplementation.
Src (show SRC Proteins) and p38 mitogen-activated protein kinase (show MAPK14 Proteins) activities are critical for regulating nSMase2 phosphorylation.
Smpd3 was identified as a redox-sensitive enzyme, whose basal activity mediated changes in its oligomeric state.
Data confirms a crucial pro-survival role for SMPD3 during embryonic development.
Smpd3/nSMase2-ceramide-Akt (show AKT1 Proteins) signaling axis negatively regulates BMP-induced chondrocyte maturation.
The H2O2-induced src (show SRC Proteins)/PDGFRbeta/SK1 (show SPHK1 Proteins) signaling cascade was impaired in nSMase2-deficient fro/fro cells and was rescued by exogenous C2Cer that activated src (show SRC Proteins)/PDGFRbeta/SK1 (show SPHK1 Proteins).
Neutral sphingomyelinase 2 deficiency is associated with lung anomalies similar to emphysema.
a requirement for nSMase2-mediated cancer cell exosomal miRNAs in the regulation of metastasis through the induction of angiogenesis in inoculated tumors.
low oxLDL concentration triggers sprouting angiogenesis that involves ROS (show ROS1 Proteins)-induced activation of the neutral sphingomyelinase-2/sphingosine kinase-1 (show SPHK1 Proteins) pathway, and is effectively inhibited by GW4869.
nSMase2 is a novel p53 (show TP53 Proteins) target gene, regulated by the DNA damage pathway to induce cell growth arrest.
nSMase2 involvement in cellular processes including inflammatory signaling, exosome generation, cell growth, and apoptosis, which in turn play important roles in pathologies such as cancer metastasis, Alzheimer's disease
SMPD3 plays an important role in the release of microRNAs into extracellular spaces.
The data shows that nSMase3 acts as a signaling nSMase (show SMPD2 Proteins) in skeletal muscle that is essential for TNF (show TNF Proteins)-stimulated oxidant activity.
This is the first report on the critical role of ceramide generated by nSMase2 in stem cell ciliogenesis and differentiation.
We found upregulation of specific sphingolipid enzymes, namely sphingomyelin synthase 1 (SMS1 (show SGMS1 Proteins)), sphingomyelinase 3 (SMPD3), and glucosylceramide synthase (GCS (show UGCG Proteins)) in the endometrium of endometriotic women.
The H2O2-induced src (show SRC Proteins)/PDGFRbeta/SK1 signaling cascade was impaired in nSMase2-deficient fro/fro cells and was rescued by exogenous C2Cer that activated src (show SRC Proteins)/PDGFRbeta/SK1.
This study establishes NSMase2 as a pivotal enzyme in the onset of endothelial endoplasmic reticulum stress-mediated vascular dysfunction.
Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Acts as a regulator of postnatal development and participates in bone and dentin mineralization. Overexpression enhances cell death, suggesting that it may be involved in apoptosis control. May be involved in IL-1-beta-induced JNK activation in hepatocytes. May act as a mediator in transcriptional regulation of NOS2/iNOS via the NF- kappa-B activation under inflammatory conditions.
, neutral sphingomyelinase 2
, neutral sphingomyelinase II
, sphingomyelin phosphodiesterase 3
, confluent 3Y1 cell-associated 1
, confluent 3Y1 cell-associated protein 1
, neutral sphingomyelin phosphodiesterase 3