Sphingosine Kinase 1 Proteins (SPHK1)

The protein encoded by SPHK1 catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Additionally we are shipping Sphingosine Kinase 1 Antibodies (204) and Sphingosine Kinase 1 Kits (10) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SPHK1 8877 Q9NYA1
SPHK1 20698 Q8CI15
SPHK1 170897 Q91V26
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Top Sphingosine Kinase 1 Proteins at antibodies-online.com

Showing 10 out of 15 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
HOST_Baculovirus infected Insect Cells Human Un-conjugated 50 μg Log in to see 20 to 21 Days
$338.80
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 18 Days
$864.00
Details
HOST_Baculovirus infected Insect Cells Human GST tag,His tag 50 μg Log in to see 20 to 21 Days
$338.80
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HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,054.33
Details
Insect Cells Human GST tag   5 μg Log in to see 11 to 12 Days
$564.48
Details
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$322.08
Details

SPHK1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , ,
, , ,
Mouse (Murine) ,

Rat (Rattus) ,

More Proteins for Sphingosine Kinase 1 (SPHK1) Interaction Partners

Fruit Fly (Drosophila melanogaster) Sphingosine Kinase 1 (SPHK1) interaction partners

  1. Sk1 and Sk2 are not redundant in biological function and are essential for diverse physiological functions in Drosophila

Arabidopsis thaliana Sphingosine Kinase 1 (SPHK1) interaction partners

  1. SPHK/phyto-S1P (show MBTPS1 Proteins) and PLDalpha1A are co-dependent in amplification of response to ABA, mediating stomatal closure in Arabidopsis.

  2. Sphingosine kinase 1 phosphorylates sphingosine-1-phosphate and phytosphingosine-1-phosphate, and is coordinately regulated with sphingosine-1-phosphate phosphatase.

Rabbit Sphingosine Kinase 1 (SPHK1) interaction partners

  1. Melatonin administration significantly inhibited those changes and induced a decreased immunoreactivity for rabbit hemorrhagic disease virus VP60 antigen in the liver. Results obtained indicate that the SphK1/S1P (show MBTPS1 Proteins) system activates in parallel to viral replication and the inflammatory process induced by the virus.

Human Sphingosine Kinase 1 (SPHK1) interaction partners

  1. we identified sphingosine kinase 1 (SPHK1) as a novel target of miR (show MLXIP Proteins)-506, the expression of which inhibited the SPHK1/Akt (show AKT1 Proteins)/NF-kappaB (show NFKB1 Proteins) signaling pathway, which is activated in pancreatic cancer. High SPHK1 expression was significantly associated with poor survival in a large cohort of pancreatic cancer specimens.

  2. Inhibition of SPHK1 in human acute myeloid leukemia (show BCL11A Proteins) cells induces MCL1 (show MCL1 Proteins) degradation and caspase (show CASP3 Proteins)-dependent cell death.

  3. The analysis suggests that the catalytic function and regulation of SPHK1 and SPHK2 (show SPHK2 Proteins) might be dependent on their conformational mobility. (Review)

  4. our data suggest that SphK1 modulates the expression of EMT (show ITK Proteins)-related markers and cell migration by regulating the expression of p-FAK (show PTK2 Proteins) in CRC (show CALR Proteins) cells. Thus, SphK1 may play a functional role in mediating the EMT (show ITK Proteins) process in CRC (show CALR Proteins).

  5. These results highlight the importance of sphingosine and its conversion to sphingosine-1-phosphate by SphK1 in endocytic membrane trafficking.

  6. By simulating therapeutic strategies that target multiple nodes of the pathway such as Raf and SphK1, we conclude that combination therapy should be much more effective in blocking VEGF signaling to EKR1/2. The model has important implications for interventions that target signaling pathways in angiogenesis relevant to cancer, vascular diseases, and wound healing.

  7. SphK1 is regulated by PDGF (show PDGFA Proteins)-BB in pulmonary artery smooth muscle cells via the transcription factor Egr-1 (show EGR1 Proteins), promoting cell proliferation.

  8. Melatonin-treated cells also exhibited an inhibition of the SphK1/S1P (show MBTPS1 Proteins) axis. Antifibrogenic effect of SphK1 inhibition was confirmed by treatment of LX2 cells with PF543. Abrogation of the lipid signaling pathway by the indole reveals novel molecular pathways that may account for the protective effect of melatonin in liver fibrogenesis.

  9. demonstrated the roles played by miR (show MLXIP Proteins)-144-3p and FN1 (show FN1 Proteins) in mediating the oncogenic function of SphK1, which enhanced the understanding of the etiology of PTC (show F9 Proteins)

  10. SphK1 is associated with the proliferation and invasiveness of CRC (show CALR Proteins) cells and the SphK1 gene may contribute to a novel therapeutic approach against CRC (show CALR Proteins).

Mouse (Murine) Sphingosine Kinase 1 (SPHK1) interaction partners

  1. donor islets from mice deficient in Sphk1 KO contain a reduced number of resident intraislet vascular endothelial cells. The main product of Sphk1, sphingosine-1-phosphate, controls the migration of intraislet endothelial cells in vitro. In vivo, Sphk1 knockout islets have an impaired ability to cure diabetes compared with wild-type controls.

  2. Sphingosine kinase 1 worsens pancreatic cancer peritoneal carcinomatosis by stimulation of proliferation of cancer cells.

  3. These results highlight the importance of sphingosine and its conversion to sphingosine-1-phosphate by SphK1 in endocytic membrane trafficking.

  4. Melatonin-treated cells also exhibited an inhibition of the SphK1/S1P (show S1PR1 Proteins) axis. Antifibrogenic effect of SphK1 inhibition was confirmed by treatment of LX2 cells with PF543. Abrogation of the lipid signaling pathway by the indole reveals novel molecular pathways that may account for the protective effect of melatonin in liver fibrogenesis.

  5. These findings suggest that the inhibitory effect of these plant extracts on the activation of AGEs/RAGE (show AGER Proteins)/SphK1 signaling pathway in db/db (show LEPR Proteins) diabetic mice kidney is a novel mechanism by which they exert renoprotective effects in diabetic nephropathy.

  6. Keratinocyte-specific deletion of Traf2 (show TRAF2 Proteins), but not Sphk1 deficiency, disrupted TNF (show TNF Proteins) mediated NF-kappaB (show NFKB1 Proteins) and MAP kinase (show MAPK1 Proteins) signalling and caused epidermal hyperplasia and psoriatic skin inflammation.

  7. SphK1 dependent PKC-delta (show PKCd Proteins) activation plays an important role in promoting NF-kappaB (show NFKB1 Proteins) activation and inflammatory response in acute liver failure, and inhibition of PKC-delta (show PKCd Proteins) activation might be a potential therapeutic strategy for this disease.

  8. Inhibition of SphK1 ameliorates drug-induced acute liver failure by reducing HMGB1 (show HMGB1 Proteins) cytoplasmic translocation in liver cells.

  9. Collectively, our results demonstrate that PF-543 exerts potent anti-CRC activity in vitro and in vivo.

  10. transient receptor potential channel 1 suppression of basal sphingosine kinase 1 activity enables endothelial cell-barrier destabilization by edemagenic agonists

Sphingosine Kinase 1 (SPHK1) Protein Profile

Protein Summary

The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Sphingosine Kinase 1 Proteins (SPHK1)

  • Sphingosine kinase 1 (Sk1)
  • sphingosine kinase 1 (SPHK1)
  • sphingosine kinase 1 (sphk1)
  • sphingosine kinase 1 (LOC100357790)
  • sphingosine kinase 1 (Sphk1)
  • 1110006G24Rik protein
  • CG1747 protein
  • Dmel\\CG1747 protein
  • F18E5.160 protein
  • F18E5_160 protein
  • Sk1 protein
  • sphingosine kinase 1 protein
  • SPHK protein
  • SPHK1 protein
  • Spk1 protein

Protein level used designations for Sphingosine Kinase 1 Proteins (SPHK1)

CG1747-PA , CG1747-PB , Sk1-PA , Sk1-PB , sphingosine kinase 1 , sphingosine kinase I , SK 1 , SPK 1

GENE ID SPECIES
32089 Drosophila melanogaster
427803 Gallus gallus
495437 Xenopus laevis
738821 Pan troglodytes
828239 Arabidopsis thaliana
100058875 Equus caballus
100357790 Oryctolagus cuniculus
8877 Homo sapiens
20698 Mus musculus
618605 Bos taurus
170897 Rattus norvegicus
483329 Canis lupus familiaris
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