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Sphingosine Kinase 2 Proteins (SPHK2)

SPHK2 encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Additionally we are shipping Sphingosine Kinase 2 Antibodies (149) and Sphingosine Kinase 2 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SPHK2 56848 Q9NRA0
SPHK2 56632 Q9JIA7
Rat SPHK2 SPHK2 308589  
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Top Sphingosine Kinase 2 Proteins at

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
HOST_Sf-9 Cells Human His tag   10 μg Log in to see 4 to 6 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

SPHK2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
Mouse (Murine)

More Proteins for Sphingosine Kinase 2 (SPHK2) Interaction Partners

Fruit Fly (Drosophila melanogaster) Sphingosine Kinase 2 (SPHK2) interaction partners

  1. Sk1 and Sk2 are not redundant in biological function and are essential for diverse physiological functions in Drosophila

Human Sphingosine Kinase 2 (SPHK2) interaction partners

  1. ABC294640 may reduce the proliferative capacity of castration-resistant prostate cancer cells through inhibition of both sphingosine kinase 2 and dihydroceramide desaturase (show DEGS1 Proteins).

  2. increased SK and SPL (show SGPL1 Proteins) mRNA expression along with reduced sphingosine 1-phosphate levels were more commonly observed in hepatocellular carcinoma tissues.

  3. Because of the unique relationship observed after serum depletion, we examined effects of siRNA for SPHK2, and found the role of SPHK2 as a growth or survival factor but not a cell proliferation inhibitor in FCS(-) culture

  4. Targeting of SphK2 by ABC294640 potently inhibits colorectal cancer cell growth both in vitro and in vivo.

  5. results define new mechanistic insights for EGF-mediated invasion and novel actions of SK2

  6. These data illuminate a novel survival mechanism and potential therapeutic target for KSHV-infected endothelial cells: SphK2-associated maintenance of viral latency

  7. Down-regulation of SphK2 increased the effects of all-trans-retinoic acid on colon cancer cells.

  8. SphK2 plays a controversial role in arthritis.

  9. IGF1R (show IGF1R Proteins) mediates insulin (show INS Proteins)-stimulated phosphorylation of both SphK1 (show SPHK1 Proteins) and SphK2.

  10. Data show that sphingosine kinase SphK1 (show SPHK1 Proteins) and sphingosine-1-phosphate (S1P (show MBTPS1 Proteins)) receptors S1P1 (show S1PR1 Proteins), S1P2 (show S1PR2 Proteins), S1P3 (show S1PR3 Proteins), and S1P5 (show S1PR5 Proteins) were expressed from primary, up to recurrent and secondary glioblastomas, with sphingosine kinase SphK2 levels were highest in primary tumors.

Mouse (Murine) Sphingosine Kinase 2 (SPHK2) interaction partners

  1. Results show that Sphk2/S1P (show S1PR1 Proteins) has an important role to play in the survival of the dopaminergic neurons, in the pathogenesis of Parkinson's disease

  2. Demonstrate that Sphk2 is the major Sphk (show SPHK1 Proteins) isoform responsible for the generation of S1P (show S1PR1 Proteins) in platelets and plays a pivotal intrinsic role in the control of platelet activation.

  3. transcriptionally up-regulated by acute endoplasmic reticulum stress through activation of ATF4 (show ATF4 Proteins) and improves perturbed hepatic glucose and fatty acid metabolism

  4. These results strongly indicate that autophagy is involved in isoflurane preconditioning both in vivo and in vitro and that SPK2 contributes to preconditioning-induced autophagy, possibly by disrupting the Beclin 1 (show BECN1 Proteins)/Bcl-2 (show BCL2 Proteins) interaction.

  5. SK1 and SK2 down-regulation reduces the motility of satellite cells.

  6. attenuation of Sphk1 (show SPHK1 Proteins), 2 activity, particularly Sphk2, leads to increased intracellular sphingolipids and autophagy in macrophages.

  7. Sphk2 provides the source of intracellular S1P (show S1PR1 Proteins) that controls thrombopoiesis, which is associated with Src (show SRC Proteins) family kinases expression and activity in megakaryocytes.

  8. sphingosine kinase-2 has a role in a murine model of lupus nephritis

  9. The function of SphK1 (show SPHK1 Proteins) and SphK2 can be interchangeable in mast cells and is species and cell type determined.

  10. Applying genetic and pharmacological approaches, we demonstrate that neuronal SPK2 isoform plays an important role in cerebral preconditioning.

Sphingosine Kinase 2 (SPHK2) Protein Profile

Protein Summary

This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with Sphingosine Kinase 2 Proteins (SPHK2)

  • Sphingosine kinase (sphK2)
  • sphk2 (sphK2)
  • Sphingosine kinase 2 (Sk2)
  • sphingosine kinase 2 (SPHK2)
  • sphingosine kinase 2 (Sphk2)
  • C76851 protein
  • CG2159 protein
  • CG32484 protein
  • DKFZp469F224 protein
  • Dmel\\CG32484 protein
  • SK-2 protein
  • sk2 protein
  • SK 2 protein
  • Sphk2 protein
  • SPK-2 protein
  • SPK 2 protein

Protein level used designations for Sphingosine Kinase 2 Proteins (SPHK2)

Sphingosine kinase , sphk2 , sphingosine kinase 2 , CG32484-PA , Sk2-PA , sphingosine kinase , sphingosine kinase II , sphingosine kinase 2-like , sphingosine kinase type 2 , SK 2 , SPK 2 , Spk2, Sk2

6363295 Bifidobacterium longum DJO10A
9958396 Bifidobacterium longum subsp. longum BBMN68
326219 Drosophila melanogaster
468943 Pan troglodytes
484401 Canis lupus familiaris
533103 Bos taurus
100054066 Equus caballus
100172513 Pongo abelii
100387720 Callithrix jacchus
100479407 Ailuropoda melanoleuca
100626023 Sus scrofa
56848 Homo sapiens
56632 Mus musculus
308589 Rattus norvegicus
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