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anti-Sphingosine Kinase 2 (SPHK2) Antibodies

SPHK2 encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Additionally we are shipping Sphingosine Kinase 2 Proteins (9) and Sphingosine Kinase 2 Kits (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SPHK2 56848 Q9NRA0
SPHK2 56632 Q9JIA7
SPHK2 308589  
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Top anti-Sphingosine Kinase 2 Antibodies at antibodies-online.com

Showing 10 out of 156 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Formalin-fixed and paraffin-embedded human cancer tissue (hepatocarcinoma) reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. The anti-SphK2 Pab is used in Western blot (Lane 1) to detect c-myc-tagged SphK2 in transfected 293 cell lysate (a c-myc antibody is used as control in Lane 2). Data is kindly provided by Dr. J. Van Brocklyn from the Ohio State University (Columbus, OH). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Formalin-fixed and paraffin-embedded human cancer tissue (breast carcinoma) reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. The anti-SphK2 Pab is used in Western blot (Lane 1) to detect c-myc-tagged SphK2 in transfected 293 cell lysate (a c-myc antibody is used as control in Lane 2). Data is kindly provided by Dr. J. Van Brocklyn from the Ohio State University (Columbus, OH). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, WB 0.1 mg Log in to see 11 to 13 Days
$565.95
Details
Human Rabbit Un-conjugated EIA, WB 0.1 mg Log in to see 11 to 13 Days
$589.05
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Mouse stomach lysates probed with SPHK2 Polyclonal Antibody, unconjugated  at 1:300 overnight at 4°C followed by a conjugated secondary antibody for 60 minutes at 37°C. 100 μL Log in to see 3 to 7 Days
$307.45
Details
Human Rabbit Un-conjugated IHC (p), WB The anti-SphK2 Pab (ABIN391349) is used in Western blot (Lane 1) to detect c-myc-tagged SphK2 in transfected 293 cell lysate (a c-myc antibody is used as control in Lane 2). Data is kindly provided by Dr. J. Van Brocklyn from the Ohio State University (Columbus, OH). Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB The anti-SphK2 Pab (ABIN391348) is used in Western blot (Lane 1) to detect c-myc-tagged SphK2 in transfected 293 cell lysate (a c-myc antibody is used as control in Lane 2). Data is kindly provided by Dr. J. Van Brocklyn from the Ohio State University (Columbus, OH). Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using SPHK2 (Phospho-Thr614) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from 293 cells, using SPHK2 (Ab-614) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using SPHK2 (Ab-614) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated ELISA, IHC, WB Western Blot (WB) analysis of 22RV1 cells using SphK2 Polyclonal Antibody. 100 μL Log in to see 16 Days
$175.80
Details

SPHK2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Sphingosine Kinase 2 Antibodies

  1. Human Polyclonal SPHK2 Primary Antibody for IHC (p), WB - ABIN391348 : Liu, Sugiura, Nava, Edsall, Kono, Poulton, Milstien, Kohama, Spiegel: Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform. in The Journal of biological chemistry 2000 (PubMed)
    Show all 8 references for ABIN391348

  2. Human Polyclonal SPHK2 Primary Antibody for EIA, WB - ABIN4620337 : Zhang, Chung, Oldenburg: A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays. in Journal of biomolecular screening 2000 (PubMed)
    Show all 5 references for ABIN4620337

  3. Human Polyclonal SPHK2 Primary Antibody for EIA, IHC (p) - ABIN359440 : Xia, Wang, Moretti, Albanese, Chai, Pitson, DAndrea, Gamble, Vadas: Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-alpha signaling. in The Journal of biological chemistry 2002 (PubMed)
    Show all 5 references for ABIN359440

  4. Human Polyclonal SPHK2 Primary Antibody for EIA, IHC (p) - ABIN359441 : Shu, Wu, Mosteller, Broek: Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinases. in Molecular and cellular biology 2002 (PubMed)
    Show all 4 references for ABIN359441

  5. Human Polyclonal SPHK2 Primary Antibody for IHC (p), WB - ABIN391349 : Shutler, Glassco, Kang, Korneluk, Mueller: Genomic structure of the human D-site binding protein (DBP) gene. in Genomics 1996 (PubMed)
    Show all 4 references for ABIN391349

  6. Human Polyclonal SPHK2 Primary Antibody for IF (p), IHC (p) - ABIN748613 : Zhang, Li, Yuan, Zhao: Hypoxic preconditioning protects cardiomyocytes against hypoxia/reoxygenation-induced cell apoptosis via sphingosine kinase 2 and FAK/AKT pathway. in Experimental and molecular pathology 2016 (PubMed)
    Show all 3 references for ABIN748613

  7. Human Polyclonal SPHK2 Primary Antibody for EIA, WB - ABIN4620350 : Okada, Ding, Sonoda, Kajimoto, Haga, Khosrowbeygi, Gao, Miwa, Jahangeer, Nakamura: Involvement of N-terminal-extended form of sphingosine kinase 2 in serum-dependent regulation of cell proliferation and apoptosis. in The Journal of biological chemistry 2005 (PubMed)

More Antibodies against Sphingosine Kinase 2 Interaction Partners

Fruit Fly (Drosophila melanogaster) Sphingosine Kinase 2 (SPHK2) interaction partners

  1. Sk1 (show SPHK1 Antibodies) and Sk2 (show KCNN2 Antibodies) are not redundant in biological function and are essential for diverse physiological functions in Drosophila

Human Sphingosine Kinase 2 (SPHK2) interaction partners

  1. Sphk2 downregulation suppresses bladder cancer progression

  2. In this study, we describe the findings that overexpression of SphK2 promotes chemoresistance in non-small cell lung cancer (NSCLC) cells. Inhibition of SphK2 might be considered as a strategy in NSCLC treatment with gefitinib

  3. the pathogenesis of CRC (show CALR Antibodies) maybe mediated by SphK2, and SphK2 could represent a selective target for the molecularly targeted treatments of CRC (show CALR Antibodies)

  4. data suggest that in vitro inhibition of SK-2 (show KCNN2 Antibodies), can compromise the integrity of the EC monolayer

  5. ABC294640 may reduce the proliferative capacity of castration-resistant prostate cancer cells through inhibition of both sphingosine kinase 2 and dihydroceramide desaturase (show DEGS1 Antibodies).

  6. increased SK and SPL (show SGPL1 Antibodies) mRNA expression along with reduced sphingosine 1-phosphate levels were more commonly observed in hepatocellular carcinoma tissues.

  7. Because of the unique relationship observed after serum depletion, we examined effects of siRNA for SPHK2, and found the role of SPHK2 as a growth or survival factor but not a cell proliferation inhibitor in FCS(-) culture

  8. Targeting of SphK2 by ABC294640 potently inhibits colorectal cancer cell growth both in vitro and in vivo.

  9. results define new mechanistic insights for EGF (show EGF Antibodies)-mediated invasion and novel actions of SK2 (show KCNN2 Antibodies)

  10. These data illuminate a novel survival mechanism and potential therapeutic target for KSHV-infected endothelial cells: SphK2-associated maintenance of viral latency

Mouse (Murine) Sphingosine Kinase 2 (SPHK2) interaction partners

  1. data suggest that in vitro inhibition of SK-2 (show PAPSS2 Antibodies), can compromise the integrity of the EC monolayer

  2. Results show that Sphk2/S1P (show S1PR1 Antibodies) has an important role to play in the survival of the dopaminergic neurons, in the pathogenesis of Parkinson's disease

  3. Demonstrate that Sphk2 is the major Sphk (show SPHK1 Antibodies) isoform responsible for the generation of S1P (show S1PR1 Antibodies) in platelets and plays a pivotal intrinsic role in the control of platelet activation.

  4. transcriptionally up-regulated by acute endoplasmic reticulum stress through activation of ATF4 (show ATF4 Antibodies) and improves perturbed hepatic glucose and fatty acid metabolism

  5. These results strongly indicate that autophagy is involved in isoflurane preconditioning both in vivo and in vitro and that SPK2 contributes to preconditioning-induced autophagy, possibly by disrupting the Beclin 1 (show BECN1 Antibodies)/Bcl-2 (show BCL2 Antibodies) interaction.

  6. SK1 (show SPHK1 Antibodies) and SK2 (show PAPSS2 Antibodies) down-regulation reduces the motility of satellite cells.

  7. attenuation of Sphk1 (show SPHK1 Antibodies), 2 activity, particularly Sphk2, leads to increased intracellular sphingolipids and autophagy in macrophages.

  8. Sphk2 provides the source of intracellular S1P (show S1PR1 Antibodies) that controls thrombopoiesis, which is associated with Src (show SRC Antibodies) family kinases expression and activity in megakaryocytes.

  9. sphingosine kinase-2 has a role in a murine model of lupus nephritis

  10. The function of SphK1 (show SPHK1 Antibodies) and SphK2 can be interchangeable in mast cells and is species and cell type determined.

Sphingosine Kinase 2 (SPHK2) Antigen Profile

Protein Summary

This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with SPHK2

  • Sphingosine kinase (sphK2) antibody
  • sphk2 (sphK2) antibody
  • Sphingosine kinase 2 (Sk2) antibody
  • sphingosine kinase 2 (SPHK2) antibody
  • sphingosine kinase 2 (Sphk2) antibody
  • C76851 antibody
  • CG2159 antibody
  • CG32484 antibody
  • DKFZp469F224 antibody
  • Dmel\\CG32484 antibody
  • SK-2 antibody
  • sk2 antibody
  • SK 2 antibody
  • Sphk2 antibody
  • SPK-2 antibody
  • SPK 2 antibody

Protein level used designations for SPHK2

Sphingosine kinase , sphk2 , sphingosine kinase 2 , CG32484-PA , Sk2-PA , sphingosine kinase , sphingosine kinase II , sphingosine kinase 2-like , sphingosine kinase type 2 , SK 2 , SPK 2 , Spk2, Sk2

GENE ID SPECIES
6363295 Bifidobacterium longum DJO10A
9958396 Bifidobacterium longum subsp. longum BBMN68
326219 Drosophila melanogaster
468943 Pan troglodytes
484401 Canis lupus familiaris
533103 Bos taurus
100054066 Equus caballus
100172513 Pongo abelii
100387720 Callithrix jacchus
100479407 Ailuropoda melanoleuca
100626023 Sus scrofa
56848 Homo sapiens
56632 Mus musculus
308589 Rattus norvegicus
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