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anti-Sphingosine-1-Phosphate Lyase 1 (SGPL1) Antibodies

Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Additionally we are shipping SGPL1 Proteins (9) and SGPL1 Kits (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SGPL1 20397 Q8R0X7
SGPL1 8879 O95470
SGPL1 286896 Q8CHN6
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Top anti-SGPL1 Antibodies at antibodies-online.com

Showing 10 out of 40 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC (p), WB SGPL1 Antibody (N-term) (ABIN656664) immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Immunohistochemistry analysis in Formalin Fixed, Paraffin Embedded Human liver tissue stained with SGPL1 Antibody (N-term) followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of SGPL1 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated. Western blot analysis using SGPL1 Antibody (N-term) Cat.-No AP53891PU-N in MDA-MB435 cell line lysates (35ug/lane). This demonstrates the SGPL1 antibody detected the SGPL1 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Cow Rabbit Un-conjugated WB 10 blots Log in to see 6 to 8 Days
$555.50
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-SGPL1 AntibodyTitration: 1.0 µg/mL  Positive Control: 721_B Whole Cell  There is BioGPS gene expression data showing that SGPL1 is expressed in 721_B 100 μL Log in to see 2 to 3 Days
$289.00
Details
Mouse Rabbit Un-conjugated ELISA, WB   100 μg Log in to see 8 to 10 Days
$449.17
Details
Human Rabbit Un-conjugated IHC (p), WB Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE) 200 μL Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Alkaline Phosphatase (AP) IHC, ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Rabbit Un-conjugated ICC, IHC (fro), IHC (p), ELISA, WB 100 μg Log in to see 9 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated IHC, WB 400 μL Log in to see 6 Days
$457.14
Details
Human Rabbit Un-conjugated WB   50 μg Log in to see 8 to 10 Days
$551.83
Details

SGPL1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine) , ,


Human ,
,

, , , , ,
Rat (Rattus) , ,


Top referenced anti-SGPL1 Antibodies

  1. Human Polyclonal SGPL1 Primary Antibody for EIA, IHC (p) - ABIN954782 : Seo, Blake, Alexander, Hahm: Sphingosine 1-phosphate-metabolizing enzymes control influenza virus propagation and viral cytopathogenicity. in Journal of virology 2010 (PubMed)
    Show all 2 references for ABIN954782

  2. Cow (Bovine) Polyclonal SGPL1 Primary Antibody for WB - ABIN265071 : Van Veldhoven, Gijsbers, Mannaerts, Vermeesch, Brys: Human sphingosine-1-phosphate lyase: cDNA cloning, functional expression studies and mapping to chromosome 10q22(1). in Biochimica et biophysica acta 2000 (PubMed)

More Antibodies against SGPL1 Interaction Partners

Mouse (Murine) Sphingosine-1-Phosphate Lyase 1 (SGPL1) interaction partners

  1. Studies suggest that S1PL is a novel endogenous suppressor of pulmonary fibrosis in human idiopathic pulmonary fibrosis and animal models.

  2. Although the observed inhibitory effect was not as strong as that of 4-deoxypyridoxine (a VB6 analog SPL inhibitor), these findings may be useful for further understanding the mechanism of action of THI.

  3. upregulation of multidrug resistance transporters contributes to the chemoresistance of S1P (show S1PR1 Antibodies) lyase-deficient MEFs

  4. Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3 (show STAT3 Antibodies)-activated microRNAs.

  5. Findings suggest that sphingosine phosphate lyase (S1P (show S1PR1 Antibodies) lyase) expressed in the thymic medullary perivascular spaces keeps the tissue sphingosine 1-phosphate low around the vessels and promotes thymic egress via up-regulation of S1P receptor 1 (S1P1 (show S1PR1 Antibodies)).

  6. Data indicate that SGPL1 sphingosine 1-phosphate lyase (aldolase (show ALD Antibodies)) mRNA is significantly increased in the periinfarct cortex.

  7. Leukocyte Sgpl1 as critical factor in monocyte macrophage differentiation and function.

  8. Inducible Sgpl1 knockout mice are protected in experimental autoimmune encephalomyelitis (EAE).

  9. S1PL deficiency increases sphingolipid formation via recycling at the expense of de novo biosynthesis in neurons.

  10. Data show that S1P (show S1PR1 Antibodies) lyase knockout mice with reduced S1P (show S1PR1 Antibodies) lyase activity (resulting in increased bio-available S1P (show S1PR1 Antibodies)) had improved survival compared with wild-type littermates.

Human Sphingosine-1-Phosphate Lyase 1 (SGPL1) interaction partners

  1. increased SK and SPL mRNA expression along with reduced sphingosine 1-phosphate levels were more commonly observed in hepatocellular carcinoma tissues.

  2. SPHK1 (show SPHK1 Antibodies):SGPL1 ratio correlated with increased cellular sphingosine-1-phosphate (S1P (show MBTPS1 Antibodies)), and S1P (show MBTPS1 Antibodies) correlated with drug resistance (IC50).

  3. Results show that dissociation of SHP-1 (show PTPN6 Antibodies) from spinophilin (show PPP1R9B Antibodies) is followed by an increase in the binding of spinophilin (show PPP1R9B Antibodies) to PP1 (show PPA1 Antibodies).

  4. Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3 (show STAT3 Antibodies)-activated microRNAs.

  5. S1P (show MBTPS1 Antibodies) lyase - by facilitating S1P1 (show S1PR1 Antibodies) receptor recycling - is essential for S1P (show MBTPS1 Antibodies)-mediated sustained signaling

  6. results highlight the importance of S1P (show MBTPS1 Antibodies) in AD suggesting the existence of a global deregulation of S1P (show MBTPS1 Antibodies) signaling in this disease from its synthesis by SphK1 (show SPHK1 Antibodies) and degradation by SPL to its signaling by the S1P1 (show S1PR1 Antibodies) receptor.

  7. The cells expressing SGPL1 in the parenchyma were CD68 (show CD68 Antibodies)(+) APCs (show APCS Antibodies).

  8. Data show that a easy assay for 2-hydroxyacyl-CoA lyase (HACL1 (show HACL1 Antibodies)) and sphingosine-1-phosphate lyase (SGPL1) activities was developed.

  9. SPL expression and activity are downregulated in cancerous tissues, there is a relationship between loss of SPL expression and prostate cancer aggressiveness.

  10. S1P (show MBTPS1 Antibodies)(ext (show EXT1 Antibodies)) mediated endothelial cell motility is dependent on intracellular S1P (show MBTPS1 Antibodies) production, which is regulated, in part, by SphK1 (show SPHK1 Antibodies) and S1PL.

SGPL1 Antigen Profile

Protein Summary

Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis.

Gene names and symbols associated with SGPL1

  • sphingosine-1-phosphate lyase 1 (SGPL1) antibody
  • sphingosine-1-phosphate lyase 1 (sgpl1) antibody
  • sphingosine phosphate lyase 1 (Sgpl1) antibody
  • sphingosine-1-phosphate lyase 1 (Sgpl1) antibody
  • AI428538 antibody
  • D10Xrf456 antibody
  • S1PL antibody
  • SGPL1 antibody
  • Spgl1 antibody
  • spl antibody
  • zgc:162153 antibody

Protein level used designations for SGPL1

sphingosine-1-phosphate lyase 1 , spl , SP-lyase 1 , SPL 1 , mSPL , sphingosine-1-phosphate aldolase , hSPL , sphingosine phosphate lyase 1

GENE ID SPECIES
100072755 Equus caballus
423714 Gallus gallus
100037007 Xenopus laevis
100037312 Danio rerio
20397 Mus musculus
8879 Homo sapiens
522515 Bos taurus
286896 Rattus norvegicus
489032 Canis lupus familiaris
100525187 Sus scrofa
100173995 Pongo abelii
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