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The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Additionally we are shipping S1PR5 Antibodies (128) and S1PR5 Kits (18) and many more products for this protein.
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Reduced DNA methylation (show HELLS Proteins) may underlie the increased expression of the S1PR5 gene in alveolar macrophages and associated defective efferocytosis in COPD (show ARCN1 Proteins).
Data indicate that the mitotic kinase Polo-like kinase 1 (PLK1) was an important effector of S1P-S1P5 signaling, and a new function of the SphK1-S1P pathway specifically in the control of mitosis in HeLa cells.
TGF-beta2 (show TGFB2 Proteins) dependent upregulation of S1P5 is required for the induction of pro-fibrotic CTGF (show CTGF Proteins) by TGF-beta (show TGFB1 Proteins) in mesangial cells.
This report is the first to demonstrate a reduction in S1P5 in multiple sclerosis lesions, which parallels that of myelin loss.
Data show that sphingosine kinase SphK1 (show SPHK1 Proteins) and sphingosine-1-phosphate (S1P (show MBTPS1 Proteins)) receptors S1P1 (show S1PR1 Proteins), S1P2 (show S1PR2 Proteins), S1P3 (show S1PR3 Proteins), and S1P5 were expressed from primary, up to recurrent and secondary glioblastomas, with sphingosine kinase SphK2 (show SPHK2 Proteins) levels were highest in primary tumors.
Edg-5 (show S1PR2 Proteins) receptor in brain endothelial cells contributes to optimal barrier formation and maintenance of immune quiescence of the barrier endothelium.
The decreased expression level of S1PR5 on NK cells is associated with graft versus host disease occurrence after allogeneic hematopoietic stem cell transplantation.
The molecular identity, functional properties, and expression profile of the S1P5 (Edg-8) receptor have been characterized.
FTY720 induces time-dependent modulation of S1P (show MBTPS1 Proteins) receptors on human OPCs with consequent functional responses that are directly relevant for the remyelination process.
The centrosomal sphingosine-1-phosphate receptor 5 might function as an intracellular target of sphingosine-1-phosphate linked to regulation of mitosis.
Coordinated changes in CXCR4 (show CXCR4 Proteins) and S1P5 responsiveness govern NK-cell trafficking.
Fndings suggest that S1P (show S1PR1 Proteins)(5) may mediate the effects of S1P (show S1PR1 Proteins) in terms of regulating ERK-1 (show MAPK3 Proteins)/2 signaling in ES cells.
Edg8/S1P5 activation on oligodendroglial cells modulates two distinct functional pathways mediating either process retraction or cell survival and that these effects depend on the developmental stage of the cell.
Sphingosine 1-phosphate receptors regulate chemokine (show CCL1 Proteins)-driven transendothelial migration of lymph node but not splenic T cells.
KLF2 (show KLF2 Proteins) regulates T cell homeostasis at least partly by controlling CD62L (show SELL Proteins) and S1P1 (show S1PR1 Proteins) expression, and therefore T cell egress from the thymus and circulation in the periphery.
These findings identify S1P5 as a T-bet-induced gene that is required for natural killer cell egress from lymph nodes and bone marrow.
The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG receptors. Some EDG receptors (e.g., EDG1\; MIM 601974) are S1P receptors\; others (e.g., EDG2\; MIM 602282) are LPA receptors.
S1P receptor 5
, S1P receptor Edg-8
, endothelial differentiation G-protein-coupled receptor 8
, endothelial differentiation, sphingolipid G-protein-coupled receptor, 8
, sphingosine 1-phosphate receptor 5
, sphingosine 1-phosphate receptor EDG8
, sphingosine 1-phosphate receptor Edg-8
, Sphingosine 1-phosphate receptor Edg-8
, endothelial differentiation, sphingolipid G-protein-coupled receptor 8
, lysophospholipid receptor B4
, sphingosine-1-phosphate receptor LPB4
, nerve growth factor-regulated G-protein-coupled receptor 1