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The protein encoded by SPIB is a transcriptional activator that binds to the PU-box (5'-GAGGAA-3') and acts as a lymphoid-specific enhancer. Additionally we are shipping SPIB Proteins (4) and many more products for this protein.
Showing 10 out of 46 products:
Human Polyclonal SPIB Primary Antibody for WB - ABIN1881823
Schmidlin, Diehl, Nagasawa, Scheeren, Schotte, Uittenbogaart, Spits, Blom: Spi-B inhibits human plasma cell differentiation by repressing BLIMP1 and XBP-1 expression. in Blood 2008
Show all 5 references for ABIN1881823
Dog (Canine) Polyclonal SPIB Primary Antibody for WB - ABIN2780475
Dontje, Schotte, Cupedo, Nagasawa, Scheeren, Gimeno, Spits, Blom: Delta-like1-induced Notch1 signaling regulates the human plasmacytoid dendritic cell versus T-cell lineage decision through control of GATA-3 and Spi-B. in Blood 2006
Show all 2 references for ABIN2780475
Human Monoclonal SPIB Primary Antibody for ICC, FACS - ABIN1098113
Marshall, Dunham, Major: Transcription factor Spi-B binds unique sequences present in the tandem repeat promoter/enhancer of JC virus and supports viral activity. in The Journal of general virology 2010
Show all 2 references for ABIN1098113
Chicken Polyclonal SPIB Primary Antibody for WB - ABIN2777288
Geng, Vedeckis: c-Myb and members of the c-Ets family of transcription factors act as molecular switches to mediate opposite steroid regulation of the human glucocorticoid receptor 1A promoter. in The Journal of biological chemistry 2005
spib is required for myeloid specification, and, in its absence, primitive myeloid cells retain hemangioblast-like characteristics and fail to migrate.
Findings establish a molecular hierarchy among POU2F2, SPIB and ID2 during B-cell differentiation, and suggest that aberrant expression of these transcription factors plays an important role in arresting plasmacytic differentiation in WM.
The SRC (show SRC Antibodies) family tyrosine kinase (show TXK Antibodies) HCK (show HCK Antibodies) and the ETS (show ETS1 Antibodies) family transcription factors SPIB and EHF (show EHF Antibodies) regulate transcytosis across a human follicle-associated epithelium model.
Our data indicate that the CBFbeta (show CBFB Antibodies)-SMMHC's C-terminus is essential to induce embryonic hematopoietic defects and leukemogenesis.
Fine mapping identified 26 single-nucleotide polymorphisms (SNPs) across the CLEC16A (show CLEC16A Antibodies)-SOCS1 (show SOCS1 Antibodies) and 11 SNPs across the SPIB locus with significant association to primary biliary cirrhosis.
Data show that in a cereblon (show CRBN Antibodies)-dependent fashion, lenalidomide downregulates IRF4 (show IRF4 Antibodies) and SPIB, transcription factors that together prevent IFNbeta production.
The transcription factor Spi-B regulates human plasmacytoid dendritic cell survival through direct induction of the antiapoptotic gene BCL2 (show BCL2 Antibodies)-A1.
The effect of mutating Spi-B-binding sites within the JC virus promoter/enhancer on early viral gene expression strongly suggests a role for Spi-B binding to the viral promoter/enhancer in the activation of early viral gene expression.
These results suggest that Spi-B could regulate JC virus gene expression in susceptible cells, and may play an important role in JC virus activity in the immune and nervous systems.
Spi-B is expressed in plasmacytoid dendritic cell precursors and inhibits T-, B-, and NK-cell development
Spi-B is a key regulator of human pDC (show PNKD Antibodies) development.
Our results suggest that complementary biological functions of PU.1 and Spi-B may be explained by their interaction with a similar set of regions in the genome of B cells.
Nfkb1 (show NFKB1 Antibodies) transcriptional activation by PU.1 and Spi-B promotes toll (show TLR4 Antibodies)-like receptor-mediated B cell proliferation.
Data show that transcription factor Spi-B-mediated negative feedback regulation limited medullary thymic epithelial cells (mTECs) development.
there is a small M-cell population with developmental regulation that is Spi-B independent; however, Spi-B is probably a candidate master regulator of M-cell functional maturation and development by another pathway.
Data indicate that the developmental defects of plasmacytoid dendritic cells (pDC (show PDC Antibodies)) in Spi-B-deficient mice were more prominent in the bone marrow.
The Blnk (show BLNK Antibodies) promoter contains a predicted PU.1 and/or Spi-B binding site that is required for promoter activity and occupied by PU.1 and/or Spi-B.
RankL (show TNFSF11 Antibodies)-induced expression of SpiB is essential for Lgr5 (show LGR5 Antibodies) stem cell-derived epithelial precursors to develop into Peyer's patch M cells
Spi-B is an essential transcription factor that regulates M-cell differentiation.
Regulation of follicular B cell differentiation by the related E26 transformation-specific transcription factors PU.1, Spi-B, and Spi-C (show SPIC Antibodies).
DNA microarray analyses enabled us to identify two genes inhibited by v-Abl (show ABL1 Antibodies) that encode the Igk 3' enhancer-binding transcription factors Spi-B and IRF-4 (show IRF4 Antibodies).
The protein encoded by this gene is a transcriptional activator that binds to the PU-box (5'-GAGGAA-3') and acts as a lymphoid-specific enhancer. Four transcript variants encoding different isoforms have been found for this gene.
Spi-B transcription factor (Spi-1/PU.1 related) a
, transcription factor Spi-B
, Ets transcription factor Spi-B
, Spi-1/PU.1 related