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Spi-C Transcription Factor (Spi-1/PU.1 Related) Proteins (SPIC)

Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Additionally we are shipping Spi-C Transcription Factor (Spi-1/PU.1 Related) Antibodies (22) and Spi-C Transcription Factor (Spi-1/PU.1 Related) Kits (13) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SPIC 97848  
SPIC 121599 Q8N5J4
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Top Spi-C Transcription Factor (Spi-1/PU.1 Related) Proteins at antibodies-online.com

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,634.50
Details
HOST_Escherichia coli (E. coli) Toxoplasma gondii Un-conjugated   500 μg Log in to see 3 to 4 Days
$437.86
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 9 to 11 Days
$229.85
Details

SPIC Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,

More Proteins for Spi-C Transcription Factor (Spi-1/PU.1 Related) (SPIC) Interaction Partners

Mouse (Murine) Spi-C Transcription Factor (Spi-1/PU.1 Related) (SPIC) interaction partners

  1. These results indicate a novel role for Spi-C as a negative regulator of B cell development and function.

  2. Study reports that Spic regulated the development of F4/80(+)VCAM1 (show VCAM1 Proteins)(+) bone marrow macrophages (BMM) and that Spic expression in BMM and red pulp macrophages development was induced by heme, a metabolite of erythrocyte degradation.

  3. Regulation of follicular B cell differentiation by the related E26 transformation-specific transcription factors PU.1, Spi-B (show SPIB Proteins), and Spi-C.

  4. The Kit-activating mutations cooperate with Spi-1 (show SPI1 Proteins)/PU.1 overexpression to promote tumorigenic progression during erythroleukemia in mice.

  5. Spi-C has the potential to modulate PU.1 activity to promote B cell differentiation.

  6. data indicate that ectopic expression of Spi-C can impair B-cell development and function by affecting genes associated with BCR (show BCR Proteins) signaling

  7. Spi-C controls development of red pulp macrophages required for red blood cell recycling and iron homeostasis

Human Spi-C Transcription Factor (Spi-1/PU.1 Related) (SPIC) interaction partners

  1. A protein interaction between SPI-C and STAT6 (show STAT6 Proteins) is the basis for a novel mechanism for regulation of IL4 (show IL4 Proteins) induced gene expression.

Spi-C Transcription Factor (Spi-1/PU.1 Related) (SPIC) Protein Profile

Protein Summary

Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA-3') that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression (By similarity).

Gene names and symbols associated with SPIC

  • Spi-C transcription factor (Spi-1/PU.1 related) (LOC100349167)
  • serine (or cysteine) peptidase inhibitor, clade B, member 6c (Serpinb6c)
  • Spi-C transcription factor (Spi-1/PU.1 related) (SPIC)
  • Spi-C transcription factor (Spi-1/PU.1 related) (Spic)
  • AU019198 protein
  • C76171 protein
  • C76174 protein
  • C76795 protein
  • ovalbumin protein
  • Prf protein
  • Spi-C protein
  • SPI3C protein
  • SPIC protein

Protein level used designations for SPIC

Spi-C transcription factor (Spi-1/PU.1 related) , serine (or cysteine) proteinase inhibitor, clade B, member 6c , serine proteinase inhibitor member 6C , transcription factor Spi-C , pu.1-related factor

GENE ID SPECIES
100349167 Oryctolagus cuniculus
97848 Mus musculus
121599 Homo sapiens
612169 Canis lupus familiaris
616438 Bos taurus
20728 Mus musculus
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