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The protein encoded by SPIB is a transcriptional activator that binds to the PU-box (5'-GAGGAA-3') and acts as a lymphoid-specific enhancer. Additionally we are shipping SPIB Antibodies (48) and many more products for this protein.
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spib is required for myeloid specification, and, in its absence, primitive myeloid cells retain hemangioblast-like characteristics and fail to migrate.
our data indicate that SPIB expression is a clinically novel poor prognostic factor in DLBCL that contributes to treatment resistance, at least in part, through an anti-apoptotic mechanism.
Findings establish a molecular hierarchy among POU2F2, SPIB and ID2 during B-cell differentiation, and suggest that aberrant expression of these transcription factors plays an important role in arresting plasmacytic differentiation in WM.
The SRC (show SRC Proteins) family tyrosine kinase (show TXK Proteins) HCK (show HCK Proteins) and the ETS (show ETS1 Proteins) family transcription factors SPIB and EHF (show EHF Proteins) regulate transcytosis across a human follicle-associated epithelium model.
Our data indicate that the CBFbeta (show CBFB Proteins)-SMMHC's C-terminus is essential to induce embryonic hematopoietic defects and leukemogenesis.
Fine mapping identified 26 single-nucleotide polymorphisms (SNPs) across the CLEC16A-SOCS1 (show SOCS1 Proteins) and 11 SNPs across the SPIB locus with significant association to primary biliary cirrhosis.
Data show that in a cereblon (show CRBN Proteins)-dependent fashion, lenalidomide downregulates IRF4 (show IRF4 Proteins) and SPIB, transcription factors that together prevent IFNbeta production.
The transcription factor Spi-B regulates human plasmacytoid dendritic cell survival through direct induction of the antiapoptotic gene BCL2 (show BCL2 Proteins)-A1.
The effect of mutating Spi-B-binding sites within the JC virus promoter/enhancer on early viral gene expression strongly suggests a role for Spi-B binding to the viral promoter/enhancer in the activation of early viral gene expression.
These results suggest that Spi-B could regulate JC virus gene expression in susceptible cells, and may play an important role in JC virus activity in the immune and nervous systems.
Spi-B is expressed in plasmacytoid dendritic cell precursors and inhibits T-, B-, and NK-cell development
Our results suggest that complementary biological functions of PU.1 and Spi-B may be explained by their interaction with a similar set of regions in the genome of B cells.
Nfkb1 (show NFKB1 Proteins) transcriptional activation by PU.1 and Spi-B promotes toll (show TLR4 Proteins)-like receptor-mediated B cell proliferation.
Data show that transcription factor Spi-B-mediated negative feedback regulation limited medullary thymic epithelial cells (mTECs) development.
there is a small M-cell population with developmental regulation that is Spi-B independent; however, Spi-B is probably a candidate master regulator of M-cell functional maturation and development by another pathway.
Data indicate that the developmental defects of plasmacytoid dendritic cells (pDC (show PDC Proteins)) in Spi-B-deficient mice were more prominent in the bone marrow.
The Blnk (show BLNK Proteins) promoter contains a predicted PU.1 and/or Spi-B binding site that is required for promoter activity and occupied by PU.1 and/or Spi-B.
RankL (show TNFSF11 Proteins)-induced expression of SpiB is essential for Lgr5 (show LGR5 Proteins) stem cell-derived epithelial precursors to develop into Peyer's patch M cells
Spi-B is an essential transcription factor that regulates M-cell differentiation.
Regulation of follicular B cell differentiation by the related E26 transformation-specific transcription factors PU.1, Spi-B, and Spi-C (show SPIC Proteins).
DNA microarray analyses enabled us to identify two genes inhibited by v-Abl (show ABL1 Proteins) that encode the Igk 3' enhancer-binding transcription factors Spi-B and IRF-4 (show IRF4 Proteins).
The protein encoded by this gene is a transcriptional activator that binds to the PU-box (5'-GAGGAA-3') and acts as a lymphoid-specific enhancer. Four transcript variants encoding different isoforms have been found for this gene.
Spi-B transcription factor (Spi-1/PU.1 related) a
, transcription factor Spi-B
, Ets transcription factor Spi-B
, Spi-1/PU.1 related