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Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Additionally we are shipping Spi-C Transcription Factor (Spi-1/PU.1 Related) Antibodies (21) and Spi-C Transcription Factor (Spi-1/PU.1 Related) Kits (1) and many more products for this protein.
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These results indicate a novel role for Spi-C as a negative regulator of B cell development and function.
Study reports that Spic regulated the development of F4/80(+)VCAM1 (show VCAM1 Proteins)(+) bone marrow macrophages (BMM) and that Spic expression in BMM and red pulp macrophages development was induced by heme, a metabolite of erythrocyte degradation.
Regulation of follicular B cell differentiation by the related E26 transformation-specific transcription factors PU.1, Spi-B (show SPIB Proteins), and Spi-C.
The Kit-activating mutations cooperate with Spi-1 (show SPI1 Proteins)/PU.1 overexpression to promote tumorigenic progression during erythroleukemia in mice.
Spi-C has the potential to modulate PU.1 activity to promote B cell differentiation.
data indicate that ectopic expression of Spi-C can impair B-cell development and function by affecting genes associated with BCR (show BCR Proteins) signaling
Spi-C controls development of red pulp macrophages required for red blood cell recycling and iron homeostasis
A protein interaction between SPI-C and STAT6 (show STAT6 Proteins) is the basis for a novel mechanism for regulation of IL4 (show IL4 Proteins) induced gene expression.
Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA-3') that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression (By similarity).
Spi-C transcription factor (Spi-1/PU.1 related)
, serine (or cysteine) proteinase inhibitor, clade B, member 6c
, serine proteinase inhibitor member 6C
, transcription factor Spi-C
, pu.1-related factor