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anti-Spindle Assembly 6 Homolog (C. Elegans) (SASS6) Antibodies

SAS6 is necessary for centrosome duplication and functions during procentriole formation; SAS6 functions to ensure that each centriole seeds the formation of a single procentriole per cell cycle Strnad et al., (2007). Additionally we are shipping Spindle Assembly 6 Homolog (C. Elegans) Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SASS6 310807  
SASS6 163786 Q6UVJ0
SASS6 72776 Q80UK7
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Top anti-Spindle Assembly 6 Homolog (C. Elegans) Antibodies at antibodies-online.com

Showing 10 out of 41 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB SASS6 Antibody (Center)  western blot analysis in Ramos cell line lysates (35ug/lane).This demonstrates the SASS6 antibody detected the SASS6 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated WB Western Blot analysis of SASS6 expression in transfected 293T cell line by SASS6 MaxPab polyclonal antibody.Lane 1: SASS6 transfected lysate(53.9 KDa).Lane 2: Non-transfected lysate. 50 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated WB 400 μL Log in to see 6 Days
$457.14
Details
Human Rabbit Un-conjugated IP   100 μL Log in to see 8 to 10 Days
$815.83
Details
Human Rabbit Un-conjugated IP, WB   100 μL Log in to see 8 to 10 Days
$815.83
Details
Human Rabbit APC ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Rabbit Alexa Fluor 647 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit FITC IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details

SASS6 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Spindle Assembly 6 Homolog (C. Elegans) Antibodies

  1. Human Polyclonal SASS6 Primary Antibody for WB - ABIN531143 : Inanç, Pütz, Lalor, Dockery, Kuriyama, Gergely, Morrison: Abnormal centrosomal structure and duplication in Cep135-deficient vertebrate cells. in Molecular biology of the cell 2013 (PubMed)
    Show all 2 references for ABIN531143

More Antibodies against Spindle Assembly 6 Homolog (C. Elegans) Interaction Partners

Fruit Fly (Drosophila melanogaster) Spindle Assembly 6 Homolog (C. Elegans) (SASS6) interaction partners

  1. These results indicate that centriole biogenesis does not strictly depend on SAS-6 self-assembly, and may require preexisting centrioles to ensure structural accuracy, fundamentally deviating from the current paradigm.

  2. Thus, efficient centriole duplication in flies requires the homo-oligomerisation of both Sas-6 and Ana2.

  3. DSas-6 and Ana2 normally cooperate to drive the formation of the centriole inner cartwheel and they promote both centriole duplication and centriole cohesion in a Sak/Plk4 (show PLK4 Antibodies)-dependent manner.

Human Spindle Assembly 6 Homolog (C. Elegans) (SASS6) interaction partners

  1. expression of wild-type centriolar assembly protein SAS-6 in a SAS-6-depleted background resulted in centriole sizes that are similar to wild type.

  2. Our present findings revealed that the upregulation of SASS6 expression is involved in the pathogenesis of CRC (show CALR Antibodies) and is associated with a poor prognosis among patients with colon cancer.

  3. SAS6 possesses an intrinsic microtubule assembly promoting activity and its outer exposed C-terminal tail may play critical roles in microtubule assembly and stabilizing microtubule attachment with the centriolar cartwheel.

  4. A homozygous c.185T>C missense mutation in the HsSAS-6 gene is associated with the cause of autosomal recessive primary microcephaly.

  5. HsSAS-6 homodimers are targeted to centrosomes where the local environment and high concentration of HsSAS-6 promote oligomerization, thus initiating procentriole formation.

  6. Authors propose that CEP135 (show CEP135 Antibodies) directly connects the central hub protein, hSAS (show L1CAM Antibodies)-6, to the outer microtubules, and suggest that this interaction stabilizes the proper cartwheel structure for further CPAP (show CENPJ Antibodies)-mediated centriole elongation.

  7. STIL (show STIL Antibodies) cooperates with SAS-6 and PLK4 (show PLK4 Antibodies) in the control of centriole number and represents a key centriole duplication factor in human cells.

  8. hSAS6 depletion hindered STIL (show STIL Antibodies) targeting to the procentriole, implying that STIL (show STIL Antibodies) and hSAS6 are mutually dependent for their centriolar localization.

  9. The activity of SCF (show KITLG Antibodies)-FBXW5 (show FBXW5 Antibodies) is negatively regulated by Polo-like kinase 4 (PLK4 (show PLK4 Antibodies)), which phosphorylates FBXW5 (show FBXW5 Antibodies) at Ser (show SIGLEC1 Antibodies) 151 to suppress its ability to ubiquitylate HsSAS-6.

  10. SAS-6 is required for daughter centriole formation in C. elegans. SAS-6 is a coiled-coil protein that is recruited to centrioles at the onset of the centrosome duplication cycle.

Zebrafish Spindle Assembly 6 Homolog (C. Elegans) (SASS6) interaction partners

  1. cea encodes the centriolar coiled-coil protein Sas-6, and that zebrafish Cea/Sas-6 protein localizes to centrosomes.[Cea]

  2. study determined the x-ray structure of the amino-terminal domain of SAS-6 and showed that recombinant SAS-6 self-associates in vitro into assemblies that resemble cartwheel centers

Spindle Assembly 6 Homolog (C. Elegans) (SASS6) Antigen Profile

Protein Summary

SAS6 is necessary for centrosome duplication and functions during procentriole formation\; SAS6 functions to ensure that each centriole seeds the formation of a single procentriole per cell cycle Strnad et al., (2007)

Gene names and symbols associated with SASS6

  • spindle assembly 6 homolog (C. elegans) (Sass6) antibody
  • spindle assembly 6 homolog (C. elegans) (SASS6) antibody
  • spindle assembly abnormal 6 (sas-6) antibody
  • spindle assembly 6 homolog (sass6) antibody
  • spindle assembly 6 homolog (C. elegans) (sass6) antibody
  • 2810453L12Rik antibody
  • CG15524 antibody
  • Dmel\\CG15524 antibody
  • dsas-6 antibody
  • Dsas6 antibody
  • RGD1306255 antibody
  • Sas-6 antibody
  • sas6 antibody
  • wu:fb98c12 antibody
  • zgc:55668 antibody

Protein level used designations for SASS6

spindle assembly abnormal protein 6 homolog , CG15524-PA , sas-6-PA , hsSAS-6 , cea , cellular atoll , sas-6

GENE ID SPECIES
310807 Rattus norvegicus
490142 Canis lupus familiaris
504467 Bos taurus
43555 Drosophila melanogaster
431859 Xenopus laevis
163786 Homo sapiens
72776 Mus musculus
424471 Gallus gallus
406747 Danio rerio
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