You are viewing an incomplete version of our website. Please click to reload the website as full version.

Spindle Assembly 6 Homolog (C. Elegans) Proteins (SASS6)

SAS6 is necessary for centrosome duplication and functions during procentriole formation\; SAS6 functions to ensure that each centriole seeds the formation of a single procentriole per cell cycle Strnad et al., (2007) [PubMed 17681132].[supplied by OMIM, Mar 2008].. Additionally we are shipping Spindle Assembly 6 Homolog (C. Elegans) Antibodies (41) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat SASS6 SASS6 310807  
SASS6 163786 Q6UVJ0
SASS6 72776 Q80UK7
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top Spindle Assembly 6 Homolog (C. Elegans) Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

SASS6 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Spindle Assembly 6 Homolog (C. Elegans) (SASS6) Interaction Partners

Fruit Fly (Drosophila melanogaster) Spindle Assembly 6 Homolog (C. Elegans) (SASS6) interaction partners

  1. These results indicate that centriole biogenesis does not strictly depend on SAS-6 self-assembly, and may require preexisting centrioles to ensure structural accuracy, fundamentally deviating from the current paradigm.

  2. Thus, efficient centriole duplication in flies requires the homo-oligomerisation of both Sas-6 and Ana2.

  3. DSas-6 and Ana2 normally cooperate to drive the formation of the centriole inner cartwheel and they promote both centriole duplication and centriole cohesion in a Sak/Plk4 (show PLK4 Proteins)-dependent manner.

Human Spindle Assembly 6 Homolog (C. Elegans) (SASS6) interaction partners

  1. expression of wild-type centriolar assembly protein SAS-6 in a SAS-6-depleted background resulted in centriole sizes that are similar to wild type.

  2. Our present findings revealed that the upregulation of SASS6 expression is involved in the pathogenesis of CRC (show CALR Proteins) and is associated with a poor prognosis among patients with colon cancer.

  3. SAS6 possesses an intrinsic microtubule assembly promoting activity and its outer exposed C-terminal tail may play critical roles in microtubule assembly and stabilizing microtubule attachment with the centriolar cartwheel.

  4. A homozygous c.185T>C missense mutation in the HsSAS-6 gene is associated with the cause of autosomal recessive primary microcephaly.

  5. HsSAS-6 homodimers are targeted to centrosomes where the local environment and high concentration of HsSAS-6 promote oligomerization, thus initiating procentriole formation.

  6. Authors propose that CEP135 directly connects the central hub protein, hSAS (show L1CAM Proteins)-6, to the outer microtubules, and suggest that this interaction stabilizes the proper cartwheel structure for further CPAP (show CENPJ Proteins)-mediated centriole elongation.

  7. STIL cooperates with SAS-6 and PLK4 (show PLK4 Proteins) in the control of centriole number and represents a key centriole duplication factor in human cells.

  8. hSAS6 depletion hindered STIL targeting to the procentriole, implying that STIL and hSAS6 are mutually dependent for their centriolar localization.

  9. The activity of SCF (show KITLG Proteins)-FBXW5 (show FBXW5 Proteins) is negatively regulated by Polo-like kinase 4 (PLK4 (show PLK4 Proteins)), which phosphorylates FBXW5 (show FBXW5 Proteins) at Ser (show SIGLEC1 Proteins) 151 to suppress its ability to ubiquitylate HsSAS-6.

  10. SAS-6 is required for daughter centriole formation in C. elegans. SAS-6 is a coiled-coil protein that is recruited to centrioles at the onset of the centrosome duplication cycle.

Zebrafish Spindle Assembly 6 Homolog (C. Elegans) (SASS6) interaction partners

  1. cea encodes the centriolar coiled-coil protein Sas-6, and that zebrafish Cea/Sas-6 protein localizes to centrosomes.[Cea]

  2. study determined the x-ray structure of the amino-terminal domain of SAS-6 and showed that recombinant SAS-6 self-associates in vitro into assemblies that resemble cartwheel centers

Spindle Assembly 6 Homolog (C. Elegans) (SASS6) Protein Profile

Protein Summary

SAS6 is necessary for centrosome duplication and functions during procentriole formation\; SAS6 functions to ensure that each centriole seeds the formation of a single procentriole per cell cycle Strnad et al., (2007)

Gene names and symbols associated with SASS6

  • spindle assembly 6 homolog (C. elegans) (Sass6)
  • spindle assembly 6 homolog (C. elegans) (SASS6)
  • spindle assembly abnormal 6 (sas-6)
  • spindle assembly 6 homolog (sass6)
  • spindle assembly 6 homolog (C. elegans) (sass6)
  • 2810453L12Rik protein
  • CG15524 protein
  • Dmel\\CG15524 protein
  • dsas-6 protein
  • Dsas6 protein
  • RGD1306255 protein
  • Sas-6 protein
  • sas6 protein
  • wu:fb98c12 protein
  • zgc:55668 protein

Protein level used designations for SASS6

spindle assembly abnormal protein 6 homolog , CG15524-PA , sas-6-PA , hsSAS-6 , cea , cellular atoll , sas-6

GENE ID SPECIES
310807 Rattus norvegicus
490142 Canis lupus familiaris
504467 Bos taurus
43555 Drosophila melanogaster
431859 Xenopus laevis
163786 Homo sapiens
72776 Mus musculus
424471 Gallus gallus
406747 Danio rerio
Selected quality suppliers for Spindle Assembly 6 Homolog (C. Elegans) Proteins (SASS6)
Did you look for something else?