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Probable sphingolipid transporter that plays a central role in endosomes and/or lysosomes storage.
Within the migrating perineurial glial cells, Spinster is required to downregulate Decapentaplegic (show TGFb Antibodies) signaling activity, which ceases migratory abilities. Also, Spinster affects the growth of the carpet cell, which indirectly modulates glial migration.
Spinster (Spin) encodes a putative lysosomal efflux permease with the hallmarks of a sugar transporter. Spin mutants accumulate lysosomal carbohydrates and enlarged lysosomes.
spin promotes cell death mechanisms that are regulated negatively by th and emc and positively by atg8a
Zebrafish yolk-specific not really started (nrs (show SPNS1 Antibodies)) gene is a vertebrate homolog of the Drosophila spinster gene and is essential for embryogenesis.
Probable sphingolipid transporter that plays a central role in endosomes and/or lysosomes storage. Involved in TGF-beta- mediated synaptic growth regulation both pre- and postsynaptically via its function in endosomal storage regulation. Also required during oogenesis by regulating yolk spheres storage.
, lethal (2) W5