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Spire Homolog 1 (Drosophila) (SPIRE1) ELISA Kits

Spire proteins, such as SPIRE1, are highly conserved between species. Additionally we are shipping Spire Homolog 1 (Drosophila) Antibodies (24) and Spire Homolog 1 (Drosophila) Proteins (5) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Mouse SPIRE1 SPIRE1 68166  
Anti-Human SPIRE1 SPIRE1 56907 Q08AE8
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More ELISA Kits for Spire Homolog 1 (Drosophila) Interaction Partners

Mouse (Murine) Spire Homolog 1 (Drosophila) (SPIRE1) interaction partners

  1. Spire-1 is specifically recruited at invadosomes and is part of a multi-molecular complex containing Src kinase, the formin mDia1 and actin.

  2. analysis of the molecular basis of the Spir1/formin-2 (show FMN2 ELISA Kits) interaction

  3. Spire1 and Spire2 drive two critical steps of asymmetric oocyte division.

  4. By analyzing the expression of the spir-1 gene it was shown that spir-1 and formin-2 (show FMN2 ELISA Kits) have a nearly identical expression pattern during mouse embryogenesis and in the adult brain.

Human Spire Homolog 1 (Drosophila) (SPIRE1) interaction partners

  1. Data suggest formin homology domain (FH2) of Fmn2 binds actin at filament barbed end as weak capper and plays a role in displacing WASP homology domain 2 (WH2) domains of Spire-1 from actin; competitive binding of Fmn2 vs Spire-1 aids actin assembly.

  2. This DNA damage-induced nuclear actin assembly requires two biologically and physically linked nucleation factors: Formin-2 (show FMN2 ELISA Kits) and Spire-1/Spire-2.

  3. The authors propose Spire1C isoform cooperates with INF2 to regulate actin assembly at endoplasmic reticulum-mitochondrial contacts.

  4. Spire recruits Fmn2 and facilitates its association with actin filaments barbed ends.

  5. Spire-1 is specifically recruited at invadosomes and is part of a multi-molecular complex containing Src kinase, the formin mDia1 and actin.

  6. analysis of the molecular basis of the Spir1/formin-2 (show FMN2 ELISA Kits) interaction

  7. The multifunctional character of the WH2 domains allows Spire to sequester four G-actin (show ACTB ELISA Kits) subunits binding cooperatively in a tight SA(4) complex and to nucleate, sever, and cap filaments at their barbed ends.

  8. both mammalian Spir proteins, Spir-1 and Spir-2, interact with mammalian Fmn (show FMN1 ELISA Kits) subgroup proteins formin-1 (show FMN1 ELISA Kits) and formin-2 (show FMN2 ELISA Kits)

Spire Homolog 1 (Drosophila) (SPIRE1) Antigen Profile

Antigen Summary

Spire proteins, such as SPIRE1, are highly conserved between species. They belong to the family of Wiskott-Aldrich homology region-2 (WH2) proteins, which are involved in actin organization (Kerkhoff et al., 2001

Gene names and symbols associated with SPIRE1

  • spire homolog 1 (Drosophila) (Spire1) antibody
  • spire homolog 1a (Drosophila) (spire1a) antibody
  • spire-type actin nucleation factor 1 (SPIRE1) antibody
  • 6030430B19Rik antibody
  • AI415299 antibody
  • AU022898 antibody
  • AW550622 antibody
  • si:ch211-215i13.1 antibody
  • si:zc215i13.1 antibody
  • Spir-1 antibody
  • Spir-2 antibody
  • spire1 antibody
  • zgc:153436 antibody

Protein level used designations for SPIRE1

protein spire homolog 1 , spire homolog 1 , spire actin nucleation factor 1 , spire family actin nucleation factor 1

GENE ID SPECIES
68166 Mus musculus
557962 Danio rerio
56907 Homo sapiens
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