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SplA/ryanodine Receptor Domain and SOCS Box Containing 1 Proteins (SPSB1)

Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Additionally we are shipping SPSB1 Antibodies (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SPSB1 80176 Q96BD6
SPSB1 74646 Q9D5L7
SPSB1 504407 Q5E9X6
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Top SPSB1 Proteins at antibodies-online.com

Showing 8 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 7 to 8 Days
$407.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,713.33
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 3 to 4 Days
$467.86
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   2 μg Log in to see 6 to 11 Days
$142.86
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

SPSB1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Cow (Bovine)

Top referenced SPSB1 Proteins

  1. Human SPSB1 Protein expressed in Escherichia coli (E. coli) - ABIN667909 : Wang, Li, Messing, Wu: The SPRY domain-containing SOCS box protein 1 (SSB-1) interacts with MET and enhances the hepatocyte growth factor-induced Erk-Elk-1-serum response element pathway. in The Journal of biological chemistry 2005 (PubMed)
    Show all 2 references for ABIN667909

More Proteins for SplA/ryanodine Receptor Domain and SOCS Box Containing 1 (SPSB1) Interaction Partners

Human SplA/ryanodine Receptor Domain and SOCS Box Containing 1 (SPSB1) interaction partners

  1. SPSB1 negatively regulates the TGF-beta signaling pathway through its interaction with both endogenous and overexpressed TbetaRII (and not TbetaRI) via its Spry domain.

  2. SSB1 (show SSBP1 Proteins)/2 is part of an ssDNA-binding heterotrimeric complex, SOSS which is involved in the maintenance of genome stability.

Mouse (Murine) SplA/ryanodine Receptor Domain and SOCS Box Containing 1 (SPSB1) interaction partners

  1. SPSB1 negatively regulates the TGF-beta signaling pathway through its interaction with both endogenous and overexpressed TbetaRII (and not TbetaRI) via its Spry domain.

  2. Collectively, these results demonstrate essential roles of Ssb1 in embryogenesis, spermatogenesis, and genome stability in vivo.

  3. These results suggest that SPSB1 acts through a negative-feedback loop that, together with SPSB2 (show SPSB2 Proteins), controls the extent of iNOS (show NOS2 Proteins) induction and nitric oxide production.

  4. SPSB1 and SPSB4 (show SPSB4 Proteins) bind strongly to both Par-4 (show F2RL3 Proteins) and VASA (show DDX4 Proteins) peptides.

  5. Spsb1 is responsive to stress caused by ethanol exposure in the mouse brain, which suggests that Spsb genes have acquired different regulatory mechanisms.

SPSB1 Protein Profile

Protein Summary

Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).

Gene names and symbols associated with SPSB1

  • splA/ryanodine receptor domain and SOCS box containing 1 (SPSB1)
  • splA/ryanodine receptor domain and SOCS box containing 1 (Spsb1)
  • 1110014L01Rik protein
  • 4930422J18Rik protein
  • AI596360 protein
  • AI854583 protein
  • SSB-1 protein
  • SSB1 protein

Protein level used designations for SPSB1

SPRY domain-containing SOCS box protein 1 , SPRY domain-containing SOCS box protein SSB-1 , novel SPRY domain containing protein , SSB-1

GENE ID SPECIES
80176 Homo sapiens
74646 Mus musculus
504407 Bos taurus
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