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SPSB2 encodes encodes a suppressor of cytokine signaling (SOCS) family member, and it belongs to the subfamily of proteins containing a central SPRY (repeats in splA and RyR) domain and a C-terminal SOCS box. Additionally we are shipping SplA/ryanodine Receptor Domain and SOCS Box Containing 2 Proteins (8) and many more products for this protein.
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structural changes limit high-affinity interactions for SPSB2 to aspartate-containing sequences
The SPRY domain-containing SOCS (show CISH Antibodies) box protein SPSB2 targets iNOS (show NOS2 Antibodies) for proteasomal degradation.
Genetic deletion of SOCS (show CISH Antibodies) Box Protein 2 results in a very mild thrombocytopenia.
Determined the first SPRY-domain structure of SSB-2 that adopts a novel fold and contains conserved structural determinants for binding to prostate apoptosis response protein-4 (PAR-4 (show PAWR Antibodies)).
Backbone dynamics of SSB-2 by means of Modelfree analysis.
The binding site on SSB-2 for the prostate apoptosis response-4 (Par-4 (show F2RL3 Antibodies)) protein has been mapped in finer detail using mutational analyses.
This gene encodes encodes a suppressor of cytokine signaling (SOCS) family member, and it belongs to the subfamily of proteins containing a central SPRY (repeats in splA and RyR) domain and a C-terminal SOCS box. This gene is present in a gene-rich cluster on chromosome 12p13 in the vicinity of the CD4 antigen and triosephosphate isomerase genes. Alternative splicing results in multiple transcript variants.
SPRY domain-containing SOCS box protein 2
, SPRY domain-containing SOCS box protein SSB-2
, gene-rich cluster protein C9
, gene rich cluster, C9
, gene rich cluster, C9 gene protein