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SPSB2 encodes encodes a suppressor of cytokine signaling (SOCS) family member, and it belongs to the subfamily of proteins containing a central SPRY (repeats in splA and RyR) domain and a C-terminal SOCS box. Additionally we are shipping SplA/ryanodine Receptor Domain and SOCS Box Containing 2 Proteins (8) and many more products for this protein.
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crystal structure of SPSB2 in complex with cyclic peptide inhibitor cR8 (show BHLHE40 Antibodies), at a resolution of 1.34 A
Collectively, Ssb1 (show SPSB1 Antibodies) and Ssb2 control crucial aspects of Hematopoietic stem and progenitor cells function, including proliferation and survival in vivo by resolving replicative stress to maintain genomic stability.
structural changes limit high-affinity interactions for SPSB2 to aspartate-containing sequences
The SPRY domain-containing SOCS (show CISH Antibodies) box protein SPSB2 targets iNOS (show NOS2 Antibodies) for proteasomal degradation.
Genetic deletion of SOCS (show CISH Antibodies) Box Protein 2 results in a very mild thrombocytopenia.
Determined the first SPRY-domain structure of SSB-2 that adopts a novel fold and contains conserved structural determinants for binding to prostate apoptosis response protein-4 (PAR-4 (show PAWR Antibodies)).
Backbone dynamics of SSB-2 by means of Modelfree analysis.
The binding site on SSB-2 for the prostate apoptosis response-4 (Par-4 (show F2RL3 Antibodies)) protein has been mapped in finer detail using mutational analyses.
This gene encodes encodes a suppressor of cytokine signaling (SOCS) family member, and it belongs to the subfamily of proteins containing a central SPRY (repeats in splA and RyR) domain and a C-terminal SOCS box. This gene is present in a gene-rich cluster on chromosome 12p13 in the vicinity of the CD4 antigen and triosephosphate isomerase genes. Alternative splicing results in multiple transcript variants.
SPRY domain-containing SOCS box protein 2
, SPRY domain-containing SOCS box protein SSB-2
, gene-rich cluster protein C9
, gene rich cluster, C9
, gene rich cluster, C9 gene protein