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The protein encoded by SFRS7 is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Additionally we are shipping Splicing Factor, Arginine/Serine Rich 7 Proteins (4) and Splicing Factor, Arginine/Serine Rich 7 Kits (3) and many more products for this protein.
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Human Polyclonal SFRS7 Primary Antibody for EIA, IHC (p) - ABIN954768
Kimura, Hashimoto, Nishizawa, Ito, Yamada: Novel cis-active structures in the coding region mediate CRM1-dependent nuclear export of IFN-α 1 mRNA. in Medical molecular morphology 2010
Show all 4 references for ABIN954768
Human Polyclonal SFRS7 Primary Antibody for WB - ABIN2786589
Swartz, Bor, Misawa, Rekosh, Hammarskjold: The shuttling SR protein 9G8 plays a role in translation of unspliced mRNA containing a constitutive transport element. in The Journal of biological chemistry 2007
Genome-wide identification of CD95 antigen (show FAS Antibodies) alternative splicing regulators, such as SRSF7, reveals links with iron homeostasis.
Coexpression of Dyrk1A (show DYRK1A Antibodies) and splicing factor 9G8 leads to their translocation from the nucleus to the cytoplasm and suppresses their ability to regulate tau exon 10 splicing.
Cyclic AMP-dependent protein kinase regulates 9G8-mediated alternative splicing of tau exon 10
Upregulation of total tau expression (SFRS7-independent) and tau exon 10 splicing (SFRS7-dependent), as shown in this study to be both affected by STOX1A, is known to have implications in neurodegeneration.
The authors report that siRNA knockdown of SRp20 or 9G8 resulted in about a 10 fold decrease in herpes simplex virus 1 yields and in nuclear accumulation of polyA+ RNA.
SR proteins 9G8, SC35 (show SRSF2 Antibodies), ASF/SF2 (show SRSF1 Antibodies), and SRp40 (show SRSF5 Antibodies) have effects on the utilization of the A1 to A5 splicing sites of HIV-1 RNA
SR proteins 9G8 and ASF/SF2 (show SRSF1 Antibodies) exhibit higher affinity for TAP/NXF1 (show NXF1 Antibodies) when hypophosphorylated
SR proteins ASF/SF2 (show SRSF1 Antibodies), SC35 (show SRSF2 Antibodies) and 9G8 can down-regulate the late steps of HIV-1 replication via negative impact on RNA splicing and virion production.
These results indicate that 9G8 plays a key role in regulation of exon 10 splicing and imply a pathogenic role in neurodegenerative diseases.
9G8 was shown to enhance expression of unspliced RNA containing either the Mason-Pfizer monkey virus constitutive transport element
9G8 binds to an element in exon 3 and strongly enhances the excision of GnRH intron A in the presence of minimal amount of other nuclear components
The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding different isoforms have been found for this gene.
SR splicing factor 7
, aging-associated protein 3
, splicing factor 9G8
, splicing factor, arginine/serine-rich 7, 35kDa
, splicing factor, arginine/serine-rich 7
, serine/arginine-rich splicing factor 7