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Splicing Factor 3b, Subunit 1, 155kDa Proteins (SF3B1)

SF3B1 encodes subunit 1 of the splicing factor 3b protein complex. Additionally we are shipping SF3B1 Antibodies (61) and SF3B1 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SF3B1 81898  
Rat SF3B1 SF3B1 84486  
SF3B1 23451 O75533
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Top SF3B1 Proteins at

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 49 to 54 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 49 to 54 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

SF3B1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,

More Proteins for Splicing Factor 3b, Subunit 1, 155kDa (SF3B1) Interaction Partners

Zebrafish Splicing Factor 3b, Subunit 1, 155kDa (SF3B1) interaction partners

  1. Data indicate that splicing factor 3b (show SF3B14 Proteins), subunit 1 (sf3b1) mutation causes aberrant splicing of sf3b1 resulting in functional and predicted non-functional transcripts and a 90% reduction in full-length Sf3b1 protein.

Mouse (Murine) Splicing Factor 3b, Subunit 1, 155kDa (SF3B1) interaction partners

  1. myocardial hypoxia actuates fructose metabolism in human and mouse models of pathological cardiac hypertrophy through hypoxia-inducible factor 1alpha (HIF1alpha (show HIF1A Proteins)) activation of SF3B1 and SF3B1-mediated splice switching of KHK (show KHK Proteins)-A to KHK (show KHK Proteins)-C

  2. Sf3b1 isrequired for the blastocyst formation.

  3. SF3B1 plays an important role in the regulation of hematopoietic stem cells, whereas SF3B1 haploinsufficiency itself is not associated with the myelodysplastic syndrome phenotype with ring sideroblasts.

  4. The level of Sf3b1 expression is critical for the proliferative capacity of hematopoietic stem cells. Depletion of Sf3b1 impairs proliferative capacity of hematopoietic stem cells but is not sufficient to induce myelodysplasia.

  5. SF3B1 haploinsufficiency leads to formation of ring sideroblasts in myelodysplastic syndromes.

  6. the active spliceosome, containing SAP155 phosphorylated by DYRKIA, performs pre-mRNA splicing in spermatogonia during testicular development

  7. active spliceosome, containing phosphorylated SAP155, performs pre-mRNA splicing on chromatin concomitant with transcription during testicular development.

  8. Sf3b1 and Polycomb (show CBX2 Proteins) group (PcG) proteins interaction is essential for true PcG-mediated repression of Hox (show MSH2 Proteins) genes.

Human Splicing Factor 3b, Subunit 1, 155kDa (SF3B1) interaction partners

  1. The finding of this study showed that an SF3B1 (show SF3B2 Proteins) or EIF1AX (show EIF1AX Proteins) mutation is present in a substantial subset of primary LMNs underscores that these tumors genetically resemble uveal melanoma and are different from cutaneous melanoma at the genetic level.

  2. SF3B1 (show SF3B2 Proteins)-mutated myelodysplastic syndrome with ring sideroblasts harbors more severe iron overload and corresponding over-erythropoiesis.

  3. studies reveal new mechanistic insight into SF3B1 (show SF3B2 Proteins) as a principal player in the spliceosome and as a target of inhibitor compounds

  4. SF3B1 (show SF3B2 Proteins) - novel candidate genes validated in a large case-control sample of schizophrenia.

  5. In uveal melanoma, the SF3B1 (show SF3B2 Proteins)(R625/K666) mutation results in deregulated splicing at a subset of junctions, mostly by the use of alternative 3'ss.

  6. Data show that tet methylcytosine dioxygenase 2 TET2, isocitrate dehydrogenases 1/2 IDH1 (show IDH1 Proteins)/IDH2 (show IDH2 Proteins), serine/arginine-rich splicing factor 2 SRSF2 (show SRSF2 Proteins), splicing factor 3b subunit 1 SF3B1, and ras proteins (KRAS/NRAS) are not conserved in dog mast Cell tumors.

  7. SF3B1 (show SF3B2 Proteins) mutations can propagate from hematopoietic stem cells to myeloid progeny causing myelodysplastic syndromes.

  8. Data suggest SF3B1 (show SF3B2 Proteins) mutations as a biomarker that can aid in the diagnosis of patients with sideroblastic anemia (SA), allowing for the differentiation between clonal and non-clonal cases of SA.

  9. SF3B1 (show SF3B2 Proteins) is associated with nucleosomes positioned over exons. SF3B1 (show SF3B2 Proteins) binding of nucleosomes facilitates the splicing recognition of exons.

  10. Studying transcriptome sequencing data from chronic lymphocytic leukemia, breast cancer and uveal melanoma tumor samples, we show that hundreds of cryptic 3' splice sites (3'SSs) are used in cancers with SF3B1 (show SF3B2 Proteins) mutations.

SF3B1 Protein Profile

Protein Summary

This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene names and symbols associated with SF3B1

  • splicing factor 3b, subunit 1, 155kDa (SF3B1)
  • splicing factor 3b, subunit 1, 155kDa (sf3b1)
  • splicing factor 3b, subunit 1 (sf3b1)
  • splicing factor 3b, subunit 1 (Sf3b1)
  • 155kDa protein
  • 2810001M05Rik protein
  • AA409119 protein
  • Hsh155 protein
  • MDS protein
  • PRP10 protein
  • PRPF10 protein
  • sap155 protein
  • SF3B1 protein
  • SF3b155 protein
  • TA-8 protein
  • Targ4 protein
  • wu:fb99f09 protein

Protein level used designations for SF3B1

splicing factor 3b, subunit 1, 155kDa , splicing factor 3B subunit 1 , splicing factor 3B subunit 1-like , tst , SAP 155 , pre-mRNA-splicing factor SF3b 155 kDa subunit , spliceosome-associated protein 155 , splicing factor 3b, subunit 1, 155 kDa , transforming growth factor alpha regulated gene 4 , splicing factor 3b, subunit 1, 155kD , 146 kDa nuclear protein , SF3b155 , pre-mRNA processing 10 , pre-mRNA splicing factor SF3b, 155 kDa subunit

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81898 Mus musculus
84486 Rattus norvegicus
399336 Xenopus laevis
424056 Gallus gallus
23451 Homo sapiens
488456 Canis lupus familiaris
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