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SF3B4 encodes one of four subunits of the splicing factor 3B. Additionally we are shipping Splicing Factor 3b, Subunit 4, 49kDa Proteins (6) and many more products for this protein.
Showing 10 out of 90 products:
Human Polyclonal SF3B4 Primary Antibody for WB - ABIN1881796
Watanabe, Shionyu, Kimura, Kimata, Watanabe: Splicing factor 3b subunit 4 binds BMPR-IA and inhibits osteochondral cell differentiation. in The Journal of biological chemistry 2007
Show all 4 references for 1881796
Human Polyclonal SF3B4 Primary Antibody for IHC, ELISA - ABIN1451679
Gregory, Barlow, McLay, Kaul, Swarbreck, Dunham, Scott, Howe, Woodfine, Spencer, Jones, Gillson, Searle, Zhou, Kokocinski, McDonald, Evans, Phillips, Atkinson, Cooper, Jones, Hall, Andrews, Lloyd et al.: The DNA sequence and biological annotation of human chromosome 1. ... in Nature 2006
Show all 2 references for 1451679
Human Polyclonal SF3B4 Primary Antibody for ELISA, WB - ABIN184797
Champion-Arnaud, Reed: The prespliceosome components SAP 49 and SAP 145 interact in a complex implicated in tethering U2 snRNP to the branch site. in Genes & development 1994
Cow (Bovine) Polyclonal SF3B4 Primary Antibody for WB - ABIN2778953
Nishanian, Waldman: Interaction of the BMPR-IA tumor suppressor with a developmentally relevant splicing factor. in Biochemical and biophysical research communications 2004
Sf3b4-depleted embryos show reduced expression of the neural crest genes sox10 (show SOX10 Antibodies), snail2 (show SNAI2 Antibodies) and twist at the neural plate border, associated with a broadening of the neural plate. This phenotype can be rescued by injection of wild-type human SF3B4 mRNA but not by mRNAs carrying mutations that cause Nager syndrome.
A novel synonymous variant within exon 3 of the SF3B4 gene was identified in three members of a family affected by Nager syndrome.
Chemical shift mapping showed that the SF3b145 (show SF3B2 Antibodies) fragment spanning residues 598-631 interacts with SF3b49 RRM1 (show RRM1 Antibodies), which adopts a canonical RRM fold with a topology of beta1-alpha1-beta2-beta3-alpha2-beta4.
SF3B4 mutations identified in Rodriguez Acrofacial Dysostosis patients disrupted mRNA splicing and reduced expression of DLX5, DLX6, SOX9, and SOX6 in cultured chondrocytes.
splicing factor 3b subunit 4 was found to inhibit the activity of signal transducer and activator of transcription 3 (show STAT3 Antibodies) signaling via downregulating the phosphorylation of signal transducer and activator of transcription 3 (show STAT3 Antibodies) on a tyrosine residue at position 705.
Overexpression of SF3B4, that is due to DNA copy number increase, is suggested to play a role in progression of HCC (show FAM126A Antibodies)
High SF3B4 expression is associated with hepatocellular carcinoma.
SF3B4 haploinsufficiency confirmed as the major cause of Nager syndrome.
SF3B4 mutation is associated with Nager syndrome.
These results suggest that most cases of Nager syndrome are caused by haploinsufficiency of SF3B4.
Inhibiting the induction of two proteins involved in two of the most significantly upregulated cellular processes, ribosome biogenesis (eIF6 (show EIF6 Antibodies)) and hnRNA splicing (SF3B2 (show SF3B2 Antibodies)/SF3B4), showed that human T cells can enter the cell cycle without growing in size.
This gene encodes one of four subunits of the splicing factor 3B. The protein encoded by this gene cross-links to a region in the pre-mRNA immediately upstream of the branchpoint sequence in pre-mRNA in the prespliceosomal complex A. It also may be involved in the assembly of the B, C and E spliceosomal complexes. In addition to RNA-binding activity, this protein interacts directly and highly specifically with subunit 2 of the splicing factor 3B. This protein contains two N-terminal RNA-recognition motifs (RRMs), consistent with the observation that it binds directly to pre-mRNA.
splicing factor 3B subunit 4
, splicing factor 3b, subunit 4, 49kD
, spliceosome associated protein 49
, SAP 49
, pre-mRNA-splicing factor SF3b 49 kDa subunit
, spliceosomal protein
, spliceosome-associated protein (U2 snRNP)
, spliceosome-associated protein 49