Splicing Factor 3b, Subunit 4, 49kDa Proteins (SF3B4)

SF3B4 encodes one of four subunits of the splicing factor 3B. Additionally we are shipping Splicing Factor 3b, Subunit 4, 49kDa Antibodies (89) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SF3B4 107701 Q8QZY9
Rat SF3B4 SF3B4 295270 Q6AYL5
SF3B4 10262 Q15427
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Top Splicing Factor 3b, Subunit 4, 49kDa Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
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HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
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Yeast Schizosaccharomyces pombe His tag   1 mg Log in to see 60 to 71 Days
$2,905.83
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Yeast Caenorhabditis elegans His tag   1 mg Log in to see 60 to 71 Days
$3,070.83
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SF3B4 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,

More Proteins for Splicing Factor 3b, Subunit 4, 49kDa (SF3B4) Interaction Partners

Xenopus laevis Splicing Factor 3b, Subunit 4, 49kDa (SF3B4) interaction partners

  1. Sf3b4-depleted embryos show reduced expression of the neural crest genes sox10 (show SOX10 Proteins), snail2 (show SNAI2 Proteins) and twist at the neural plate border, associated with a broadening of the neural plate. This phenotype can be rescued by injection of wild-type human SF3B4 mRNA but not by mRNAs carrying mutations that cause Nager syndrome.

Human Splicing Factor 3b, Subunit 4, 49kDa (SF3B4) interaction partners

  1. A novel synonymous variant within exon 3 of the SF3B4 gene was identified in three members of a family affected by Nager syndrome.

  2. Chemical shift mapping showed that the SF3b145 (show SF3B2 Proteins) fragment spanning residues 598-631 interacts with SF3b49 RRM1 (show RRM1 Proteins), which adopts a canonical RRM fold with a topology of beta1-alpha1-beta2-beta3-alpha2-beta4.

  3. SF3B4 mutations identified in Rodriguez Acrofacial Dysostosis patients disrupted mRNA splicing and reduced expression of DLX5, DLX6, SOX9, and SOX6 in cultured chondrocytes.

  4. splicing factor 3b subunit 4 was found to inhibit the activity of signal transducer and activator of transcription 3 (show STAT3 Proteins) signaling via downregulating the phosphorylation of signal transducer and activator of transcription 3 (show STAT3 Proteins) on a tyrosine residue at position 705.

  5. Overexpression of SF3B4, that is due to DNA copy number increase, is suggested to play a role in progression of HCC (show FAM126A Proteins)

  6. High SF3B4 expression is associated with hepatocellular carcinoma.

  7. SF3B4 haploinsufficiency confirmed as the major cause of Nager syndrome.

  8. SF3B4 mutation is associated with Nager syndrome.

  9. These results suggest that most cases of Nager syndrome are caused by haploinsufficiency of SF3B4.

  10. Inhibiting the induction of two proteins involved in two of the most significantly upregulated cellular processes, ribosome biogenesis (eIF6 (show EIF6 Proteins)) and hnRNA splicing (SF3B2 (show SF3B2 Proteins)/SF3B4), showed that human T cells can enter the cell cycle without growing in size.

Splicing Factor 3b, Subunit 4, 49kDa (SF3B4) Protein Profile

Protein Summary

This gene encodes one of four subunits of the splicing factor 3B. The protein encoded by this gene cross-links to a region in the pre-mRNA immediately upstream of the branchpoint sequence in pre-mRNA in the prespliceosomal complex A. It also may be involved in the assembly of the B, C and E spliceosomal complexes. In addition to RNA-binding activity, this protein interacts directly and highly specifically with subunit 2 of the splicing factor 3B. This protein contains two N-terminal RNA-recognition motifs (RRMs), consistent with the observation that it binds directly to pre-mRNA.

Gene names and symbols associated with SF3B4

  • Protein SAP-49 (sap-49)
  • splicing factor 3b, subunit 4 (sf3b4)
  • splicing factor 3b, subunit 4 (Sf3b4)
  • splicing factor 3b, subunit 4, 49kDa (sf3b4)
  • splicing factor 3b, subunit 4, 49kDa (SF3B4)
  • 49kDa protein
  • AFD1 protein
  • chunp6902 protein
  • fb36a04 protein
  • Hsh49 protein
  • SAP49 protein
  • SF3b49 protein
  • SF3b50 protein
  • spx protein
  • wu:fb36a04 protein

Protein level used designations for SF3B4

splicing factor 3B subunit 4 , splicing factor 3b, subunit 4, 49kD , spliceosome associated protein 49 , SAP 49 , SF3b50 , pre-mRNA-splicing factor SF3b 49 kDa subunit , spliceosomal protein , spliceosome-associated protein (U2 snRNP) , spliceosome-associated protein 49

GENE ID SPECIES
4363023 Caenorhabditis elegans
192318 Danio rerio
107701 Mus musculus
295270 Rattus norvegicus
379792 Xenopus laevis
10262 Homo sapiens
483177 Canis lupus familiaris
506123 Bos taurus
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