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The product of SHFM1 has been localized within the split hand/split foot malformation locus SHFM1 at chromosome 7. Additionally we are shipping SHFM1 Antibodies (41) and SHFM1 Kits (3) and many more products for this protein.
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Promoter methylation plays a role in modulating DSS1 gene expression. Promoter hypomethylation is a frequent event in melanoma and squamous cell carcinoma and is closely linked to poor prognosis.
DSS1 is a multifunctional and intrinsically disordered protein. (Review)
three phenotypic subregions within the SHFM1 locus link both size and genomic position of the chromosomal aberrations to the clinical variability seen in SHFM1 patients
SHFM1 confers cell cycle progression and resistance to p53 (show TP53 Proteins) stabilizing drugs in gastric cancer cells.
by targeting RPA (show RPA1 Proteins) and mimicking DNA, DSS1 functions with BRCA2 (show BRCA2 Proteins) in a two-component homologous recombination mediator complex in genome maintenance and tumor suppression
Breast cancers with high DSS1 expression have worse prognosis and shorter relapse-free survival times.
Mutation screening of the SHFM1 gene in familial breast/ovarian cancer cases.
DSS1 protein is critically involved in the maintenance of the transformed phenotype in cervical cancer cells, and that it might be a specific, robust and reliable marker for early detection, diagnosis and trea (show TREH Proteins)
DSS1 has a role in homologous recombinational repair in human cells
p63 (show RPE65 Proteins) binds to an enhancer element in the SHFM1 locus and this element controls expression of DLX6 and DLX5 (show DLX5 Proteins) which are important for limb development.
3.1 angstrom crystal structure of approximately 90-kilodalton BRCA2 domain bound to DSS1, which reveals three oligonucleotide-binding (OB) folds and a helix-turn-helix (HTH) motif
The product of this gene has been localized within the split hand/split foot malformation locus SHFM1 at chromosome 7. It has been proposed to be a candidate gene for the autosomal dominant form of the heterogeneous limb developmental disorder split hand/split foot malformation type 1. In addition, it has been shown to directly interact with BRCA2. It also may play a role in the completion of the cell cycle.
26S proteasome complex subunit DSS1
, candidate for split hand/foot malformation type 1
, split hand/foot malformation (ectrodactyly) type 1
, 26 proteasome complex subunit DSS1
, split hand/foot malformation type 1 protein homolog
, deleted in split hand/split foot protein 1
, deleted in split-hand/split-foot 1
, split hand/foot deleted protein 1
, split hand/foot malformation type 1 protein
, deleted in split hand/split foot protein 1 homolog
, split hand/foot deleted gene 1
, split hand/foot deleted protein 1 homolog