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May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis..
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Here, we present a novel mouse model of pheochromocytoma consisting of double-heterozygous mice for Pten (show PTEN Antibodies) and Sprouty1 (Spry1), which leads to pheochromocytomas that appear at earlier onset and grow at a higher rate than those from Pten (show PTEN Antibodies)+/- mice.
Cosuppression of Sprouty and Sprouty-related negative regulators of FGF signalling in prostate cancer
Sprouty gain of function disrupts lens cellular processes and growth by restricting receptor tyrosine kinase (show ERBB3 Antibodies) signaling.
In vivo analysis of thyroid glands from Spry1 knockout mice reveals that Spry1 induces a senescence-associated secretory phenotype via activation of the NFkappaB pathway.
showed that hSpry1 overexpression prevents VEGF secretion
Spry1 and Spry2 (show SPRY2 Antibodies) coordination is required for normal development of the external genitalia in mice
conjunctival epithelial Spry1 and Spry2 (show SPRY2 Antibodies) redundantly promote eyelid closure.
Findings demonstrate that Pokemon (show ZBTB7A Antibodies) suppresses Sprouty1 expression through a miR (show MLXIP Antibodies)-21-mediated mechanism, affecting the growth and proliferation of liver cancer cells.
ISG15 mRNA expression and IFN-dependent antiviral responses are enhanced in Spry1,2,4 triple knock-out mouse embryonic fibroblasts, consistent with negative feedback regulatory roles for Spry proteins in IFN-mediated signaling.
When Spry1 and Spry2 (show SPRY2 Antibodies) loss-of-function occurs in the context of heterozygosity for a null allele of the tumor suppressor gene Pten (show PTEN Antibodies), there is a striking increase in prostatic intraepithelial neoplasia and evidence of neoplastic invasion.
May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.
inhibitor of receptor tyrosine kinases
, protein sprouty homolog 1
, sprouty 1
, sprouty homolog 1a, antagonist of FGF signaling
, sprouty homolog 1b, antagonist of FGF signaling