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Sprouty Homolog 4 (Drosophila) (SPRY4) ELISA Kits

SPRY4 is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. Additionally we are shipping SPRY4 Antibodies (75) and SPRY4 Proteins (5) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Rat SPRY4 SPRY4 291610  
Anti-Human SPRY4 SPRY4 81848 Q9C004
Anti-Mouse SPRY4 SPRY4 24066 Q9WTP2
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More ELISA Kits for SPRY4 Interaction Partners

Human Sprouty Homolog 4 (Drosophila) (SPRY4) interaction partners

  1. Results identify the tumor suppressor SPRY4 as a novel molecular effector of MT1-MMP (show MMP14 ELISA Kits) affecting melanoma cell motility.

  2. Data show that proto-oncogene (show RAB1A ELISA Kits) protein B (show LEPREL2 ELISA Kits)-raf (BRAF (show BRAF ELISA Kits)) inhibition induces c-Jun N-terminal kinase (c-JUN) expression and c-JUN (show JUN ELISA Kits) abundance and activation by down-regulating SPRY2 (show SPRY2 ELISA Kits)/4 protein expression.

  3. Specific protein 1 (show SP1 ELISA Kits) plays a crucial role in the regulation of Sprouty4 in response to serum.

  4. ZNF703 was a target of SPRY4-IT1.

  5. SPRY4 is often deleted in secondary acute myeloid leukemia (show BCL11A ELISA Kits).

  6. Sprouty 2 protein, but not Sprouty 4, is an independent prognostic biomarker for human epithelial ovarian cancer.

  7. these results suggest the possibility that SPRY4-IT1 knockdown may induce apoptosis via lipin 2 (show LPIN2 ELISA Kits)-mediated alterations in lipid metabolism leading to cellular lipotoxicity.

  8. SPRY4 may function as a tumor suppressor in endometrial adenocarcinoma.

  9. Downregulation of Dusp6 (show DUSP6 ELISA Kits), Sprouty4, and Sef (show TFCP2 ELISA Kits)--negative modulators of FGF2 (show FGF2 ELISA Kits)/ERK1/2 (show MAPK1/3 ELISA Kits) signaling--was present in eutopic endometria of adenomyosis, which may play critical roles in the development of adenomyosis.

  10. demonstrated that knockdown of SPRY4-IT1 reduced cell proliferation, invasiveness, and migration

Mouse (Murine) Sprouty Homolog 4 (Drosophila) (SPRY4) interaction partners

  1. Autoregulatory loop between TGF-beta1 (show TGFB1 ELISA Kits)/miR (show MLXIP ELISA Kits)-411-5p/SPRY4 and p38 MAPK (show MAPK14 ELISA Kits) pathway in rhabdomyosarcoma modulates proliferation and differentiation.

  2. in embryos with lower Spry2 (show SPRY2 ELISA Kits);Spry4 gene dosages, we observed a non-fusion of original R2 and M1 Shh (show SHH ELISA Kits) signaling domains with consequent formation of a supernumerary tooth primordium from the isolated R2 bud

  3. We demonstrate that in spry4-/- mice inflammatory responses, such TNFalpha (show TNF ELISA Kits) secretion and macrophage/neutrophil invasion into the lesion site are reduced. In addition, astrocytic gliosis is attenuated and neuronal survival is increased.

  4. SPRY4 is a tumor suppressor at 5q whose disruption contributes to a lethal acute myeloid leukemia (show BCL11A ELISA Kits) subtype.

  5. In vivo analysis revealed that Spry4 regulated integrin beta3 levels in murine embryos and yolk sacs (show SACS ELISA Kits).

  6. We propose that Sprouty genes(Spry2 (show SPRY2 ELISA Kits) and Spry4) were implicated during evolution in reduction of the cheek teeth in Muridae, and their deletion can reveal ancestral stages of murine dental evolution.

  7. ISG15 mRNA expression and IFN-dependent antiviral responses are enhanced in Spry1,2,4 triple knock-out mouse embryonic fibroblasts, consistent with negative feedback regulatory roles for Spry proteins in IFN-mediated signaling.

  8. our results imply that Sprouty2 (show SPRY2 ELISA Kits) and -4 are downregulated in the hippocampus during postnatal brain development and that they can act as regulators of developmental axon growth.

  9. Interestingly, changes in sprouty gene dosage led to a graded change in incisor number, with progressive decreases in sprouty dosage leading to increasing numbers of teeth.

  10. Spry4 and Tpbg/5T4 (show TPBG ELISA Kits) were detected in Kit-immunoreactive cells only in Kit(K641E), but not in Kit(WT/WT) animals.

SPRY4 Antigen Profile

Antigen Summary

SPRY4 is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. It is positioned upstream of RAS (see HRAS\; MIM 190020) activation and impairs the formation of active GTP-RAS (Leeksma et al., 2002

Gene names and symbols associated with SPRY4

  • sprouty homolog 4 (Drosophila) (Spry4) antibody
  • sprouty homolog 4 (Drosophila) (SPRY4) antibody
  • sprouty homolog 4 (SPRY4) antibody
  • sprouty (Drosophila) homolog 4 (spry4) antibody
  • sprouty homolog 4 (LOC100218545) antibody
  • A030006O18Rik antibody
  • HH17 antibody
  • LOC100218545 antibody
  • sprouty4 antibody
  • SPRY4 antibody

Protein level used designations for SPRY4

protein sprouty homolog 4 , sprouty-like protein 4 , sprouty homolog 4 , SPRY domain-containing protein 4 , spry-4

291610 Rattus norvegicus
427643 Gallus gallus
705836 Macaca mulatta
100195736 Salmo salar
100218545 Taeniopygia guttata
81848 Homo sapiens
24066 Mus musculus
504593 Bos taurus
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