anti-Sprouty Homolog 4 (Drosophila) (SPRY4) Antibodies

SPRY4 is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. Additionally we are shipping SPRY4 Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SPRY4 291610  
SPRY4 81848 Q9C004
SPRY4 24066 Q9WTP2
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Top anti-SPRY4 Antibodies at antibodies-online.com

Showing 10 out of 83 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-SPRY4 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:1562500<br><b>Positive Control: </b>Hela cell lysate WB Suggested Anti-SPRY4 <br /> Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:1562500 <br /> Positive Control: Hela cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of anti-SPRY4 Antibody (C-term) in Sk-Br-3 cell line lysates (35ug/lane). SPRY4 (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Chimpanzee Rabbit Un-conjugated EIA, IHC (p), WB   0.1 mg Log in to see 12 to 15 Days
$411.18
Details
Human Rabbit Un-conjugated IHC (p), ELISA, WB Human Heart (formalin-fixed, paraffin-embedded) stained with SPRY4 antibody ABIN214620 at 2.5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 7 to 9 Days
$451.00
Details
Guinea Pig Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Human Rabbit Un-conjugated WB Western blot analysis of anti-SPRY4 Antibody (C-term) (ABIN391651) in Sk-Br-3 cell line lysates (35 µg/lane). SPRY4 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated DB Dot blot analysis of anti-Phospho-SPRY4-pY75 Antibody (ABIN389968) on nitrocellulose membrane.  50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5 µg/mL. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of Phospho-SPRY4-Y75.ctrl (ABIN652338) in K562 cell line lysates (35 µg/lane). SPRY4 (arrow) was detected using the purified polyclonal antibody. SPRY4-Y75 Antibody (ABIN652338) IHC analysis in formalin fixed and paraffin embedded brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Affinity Purified anti-Sprouty-4 antibody was used at a 2.5 µg/ml to detect cytoplasmic signal with moderate to strong staining and low background in a variety of tissues including heart, prostate, intestine, kidney and pancreas.  Strong specific staining was noted at particular cell types in some tissues (i.e. Sertoli and Leydig cells).  The antibody shows very good signal to background at 2.5 µg/ml.  This image shows Sprouty-4 staining of human heart tissue.  Tissue was formalin-fixed and paraffin embedded. 0.93 mg/ml (by UV absorbance at 280 nm) 100 μg Log in to see 1 to 2 Days
$379.00
Details

SPRY4 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Rat (Rattus)


Human , , ,


, , , , ,
Mouse (Murine)


More Antibodies against SPRY4 Interaction Partners

Human Sprouty Homolog 4 (Drosophila) (SPRY4) interaction partners

  1. Studied BAK1 (show BAK1 Antibodies), SPRY4 and GAB2 (show GAB2 Antibodies) SNPs in pediatric germ cell tumors(GCT (show QPCT Antibodies)); found a variant in SPRY4 was associated with reduced risk of GCT (show QPCT Antibodies); a variant in BAK1 (show BAK1 Antibodies) was positively associated with GCT (show QPCT Antibodies) with a strong estimated effect for testis tumors; and a SNP in GAB2 (show GAB2 Antibodies) was associated with increased risk for GCT (show QPCT Antibodies).

  2. results found that histone methylation mediated by CCAT1 could also contribute to the lower expression of SPRY4 in esophageal squamous cell carcinoma

  3. mechanistic evidence that KSRP (show KHSRP Antibodies) promotes the down-regulation of Spry4 by a previously unidentified mechanism, i.e. post-transcriptional mRNA regulation.

  4. Polymorphisms of KITLG (show KITLG Antibodies), SPRY4, and BAK1 (show BAK1 Antibodies) genes in patients with testicular germ cell tumors and individuals with infertility associated with AZFc deletion of the Y chromosome

  5. SPRY4 is involved in the development and progression of colorectal cancer.

  6. Small interfering RNA (siRNA)-mediated knockdown of SPRY4 attenuated the AREG (show AREG Antibodies)-induced down-regulation of E-cadherin (show CDH1 Antibodies).

  7. These findings suggest that SPRY4-IT1 (show HAUS3 Antibodies) plays a direct role in the regulation of metastasis and progression of osteosarcoma.

  8. Results identify the tumor suppressor SPRY4 as a novel molecular effector of MT1-MMP (show MMP14 Antibodies) affecting melanoma cell motility.

  9. Data show that proto-oncogene (show RAB1A Antibodies) protein B (show LEPREL2 Antibodies)-raf (BRAF (show BRAF Antibodies)) inhibition induces c-Jun N-terminal kinase (c-JUN) expression and c-JUN (show JUN Antibodies) abundance and activation by down-regulating SPRY2 (show SPRY2 Antibodies)/4 protein expression.

  10. Specific protein 1 (show SP1 Antibodies) plays a crucial role in the regulation of Sprouty4 in response to serum.

Mouse (Murine) Sprouty Homolog 4 (Drosophila) (SPRY4) interaction partners

  1. Irf6 (show IRF6 Antibodies) and RTK signaling interact in regulating periderm differentiation and function, as well as provide a rationale to screen for epistatic interactions between variants in IRF6 (show IRF6 Antibodies) and RTK signaling pathway genes in human orofacial clefting populations.

  2. In the present study, it is demonstrated that Spry2 (show SPRY2 Antibodies) and -4 participate in KA induced neurodegeneration possibly through inhibition of ERK (show EPHB2 Antibodies) signaling.

  3. Autoregulatory loop between TGF-beta1 (show TGFB1 Antibodies)/miR (show MLXIP Antibodies)-411-5p/SPRY4 and p38 MAPK (show MAPK14 Antibodies) pathway in rhabdomyosarcoma modulates proliferation and differentiation.

  4. in embryos with lower Spry2 (show SPRY2 Antibodies);Spry4 gene dosages, we observed a non-fusion of original R2 and M1 Shh (show SHH Antibodies) signaling domains with consequent formation of a supernumerary tooth primordium from the isolated R2 bud

  5. We demonstrate that in spry4-/- mice inflammatory responses, such TNFalpha (show TNF Antibodies) secretion and macrophage/neutrophil invasion into the lesion site are reduced. In addition, astrocytic gliosis is attenuated and neuronal survival is increased.

  6. SPRY4 is a tumor suppressor at 5q whose disruption contributes to a lethal acute myeloid leukemia (show BCL11A Antibodies) subtype.

  7. In vivo analysis revealed that Spry4 regulated integrin beta3 levels in murine embryos and yolk sacs.

  8. We propose that Sprouty genes(Spry2 (show SPRY2 Antibodies) and Spry4) were implicated during evolution in reduction of the cheek teeth in Muridae, and their deletion can reveal ancestral stages of murine dental evolution.

  9. ISG15 mRNA expression and IFN-dependent antiviral responses are enhanced in Spry1,2,4 triple knock-out mouse embryonic fibroblasts, consistent with negative feedback regulatory roles for Spry proteins in IFN-mediated signaling.

  10. our results imply that Sprouty2 (show SPRY2 Antibodies) and -4 are downregulated in the hippocampus during postnatal brain development and that they can act as regulators of developmental axon growth.

SPRY4 Antigen Profile

Protein Summary

SPRY4 is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. It is positioned upstream of RAS (see HRAS\; MIM 190020) activation and impairs the formation of active GTP-RAS (Leeksma et al., 2002

Gene names and symbols associated with SPRY4

  • sprouty homolog 4 (Drosophila) (Spry4) antibody
  • sprouty homolog 4 (Drosophila) (SPRY4) antibody
  • sprouty homolog 4 (SPRY4) antibody
  • sprouty (Drosophila) homolog 4 (spry4) antibody
  • sprouty homolog 4 (LOC100218545) antibody
  • A030006O18Rik antibody
  • HH17 antibody
  • LOC100218545 antibody
  • sprouty4 antibody
  • SPRY4 antibody

Protein level used designations for SPRY4

protein sprouty homolog 4 , sprouty-like protein 4 , sprouty homolog 4 , SPRY domain-containing protein 4 , spry-4

GENE ID SPECIES
291610 Rattus norvegicus
427643 Gallus gallus
705836 Macaca mulatta
100195736 Salmo salar
100218545 Taeniopygia guttata
81848 Homo sapiens
24066 Mus musculus
504593 Bos taurus
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