Sprouty Homolog 4 (Drosophila) (SPRY4) ELISA Kits

SPRY4 is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. Additionally we are shipping SPRY4 Antibodies (83) and SPRY4 Proteins (5) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Rat SPRY4 SPRY4 291610  
Anti-Human SPRY4 SPRY4 81848 Q9C004
Anti-Mouse SPRY4 SPRY4 24066 Q9WTP2
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More ELISA Kits for SPRY4 Interaction Partners

Human Sprouty Homolog 4 (Drosophila) (SPRY4) interaction partners

  1. Studied BAK1 (show BAK1 ELISA Kits), SPRY4 and GAB2 (show GAB2 ELISA Kits) SNPs in pediatric germ cell tumors(GCT (show QPCT ELISA Kits)); found a variant in SPRY4 was associated with reduced risk of GCT (show QPCT ELISA Kits); a variant in BAK1 (show BAK1 ELISA Kits) was positively associated with GCT (show QPCT ELISA Kits) with a strong estimated effect for testis tumors; and a SNP in GAB2 (show GAB2 ELISA Kits) was associated with increased risk for GCT (show QPCT ELISA Kits).

  2. results found that histone methylation mediated by CCAT1 could also contribute to the lower expression of SPRY4 in esophageal squamous cell carcinoma

  3. mechanistic evidence that KSRP (show KHSRP ELISA Kits) promotes the down-regulation of Spry4 by a previously unidentified mechanism, i.e. post-transcriptional mRNA regulation.

  4. Polymorphisms of KITLG (show KITLG ELISA Kits), SPRY4, and BAK1 (show BAK1 ELISA Kits) genes in patients with testicular germ cell tumors and individuals with infertility associated with AZFc deletion of the Y chromosome

  5. SPRY4 is involved in the development and progression of colorectal cancer.

  6. Small interfering RNA (siRNA)-mediated knockdown of SPRY4 attenuated the AREG (show AREG ELISA Kits)-induced down-regulation of E-cadherin (show CDH1 ELISA Kits).

  7. These findings suggest that SPRY4-IT1 plays a direct role in the regulation of metastasis and progression of osteosarcoma.

  8. Results identify the tumor suppressor SPRY4 as a novel molecular effector of MT1-MMP (show MMP14 ELISA Kits) affecting melanoma cell motility.

  9. Data show that proto-oncogene (show RAB1A ELISA Kits) protein B (show LEPREL2 ELISA Kits)-raf (BRAF (show BRAF ELISA Kits)) inhibition induces c-Jun N-terminal kinase (c-JUN) expression and c-JUN (show JUN ELISA Kits) abundance and activation by down-regulating SPRY2 (show SPRY2 ELISA Kits)/4 protein expression.

  10. Specific protein 1 (show SP1 ELISA Kits) plays a crucial role in the regulation of Sprouty4 in response to serum.

Mouse (Murine) Sprouty Homolog 4 (Drosophila) (SPRY4) interaction partners

  1. In the present study, it is demonstrated that Spry2 (show SPRY2 ELISA Kits) and -4 participate in KA induced neurodegeneration possibly through inhibition of ERK (show EPHB2 ELISA Kits) signaling.

  2. Autoregulatory loop between TGF-beta1 (show TGFB1 ELISA Kits)/miR (show MLXIP ELISA Kits)-411-5p/SPRY4 and p38 MAPK (show MAPK14 ELISA Kits) pathway in rhabdomyosarcoma modulates proliferation and differentiation.

  3. in embryos with lower Spry2 (show SPRY2 ELISA Kits);Spry4 gene dosages, we observed a non-fusion of original R2 and M1 Shh (show SHH ELISA Kits) signaling domains with consequent formation of a supernumerary tooth primordium from the isolated R2 bud

  4. We demonstrate that in spry4-/- mice inflammatory responses, such TNFalpha (show TNF ELISA Kits) secretion and macrophage/neutrophil invasion into the lesion site are reduced. In addition, astrocytic gliosis is attenuated and neuronal survival is increased.

  5. SPRY4 is a tumor suppressor at 5q whose disruption contributes to a lethal acute myeloid leukemia (show BCL11A ELISA Kits) subtype.

  6. In vivo analysis revealed that Spry4 regulated integrin beta3 levels in murine embryos and yolk sacs (show SACS ELISA Kits).

  7. We propose that Sprouty genes(Spry2 (show SPRY2 ELISA Kits) and Spry4) were implicated during evolution in reduction of the cheek teeth in Muridae, and their deletion can reveal ancestral stages of murine dental evolution.

  8. ISG15 mRNA expression and IFN-dependent antiviral responses are enhanced in Spry1,2,4 triple knock-out mouse embryonic fibroblasts, consistent with negative feedback regulatory roles for Spry proteins in IFN-mediated signaling.

  9. our results imply that Sprouty2 (show SPRY2 ELISA Kits) and -4 are downregulated in the hippocampus during postnatal brain development and that they can act as regulators of developmental axon growth.

  10. Interestingly, changes in sprouty gene dosage led to a graded change in incisor number, with progressive decreases in sprouty dosage leading to increasing numbers of teeth.

SPRY4 Antigen Profile

Antigen Summary

SPRY4 is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. It is positioned upstream of RAS (see HRAS\; MIM 190020) activation and impairs the formation of active GTP-RAS (Leeksma et al., 2002

Gene names and symbols associated with SPRY4

  • sprouty homolog 4 (Drosophila) (Spry4) antibody
  • sprouty homolog 4 (Drosophila) (SPRY4) antibody
  • sprouty homolog 4 (SPRY4) antibody
  • sprouty (Drosophila) homolog 4 (spry4) antibody
  • sprouty homolog 4 (LOC100218545) antibody
  • A030006O18Rik antibody
  • HH17 antibody
  • LOC100218545 antibody
  • sprouty4 antibody
  • SPRY4 antibody

Protein level used designations for SPRY4

protein sprouty homolog 4 , sprouty-like protein 4 , sprouty homolog 4 , SPRY domain-containing protein 4 , spry-4

291610 Rattus norvegicus
427643 Gallus gallus
705836 Macaca mulatta
100195736 Salmo salar
100218545 Taeniopygia guttata
81848 Homo sapiens
24066 Mus musculus
504593 Bos taurus
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