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anti-Src Homology 2 Domain Containing Adaptor Protein B (SHB) Antibodies

Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. Additionally we are shipping SHB Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SHB 6461 Q15464
SHB 362513  
SHB 230126 Q6PD21
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Top anti-SHB Antibodies at antibodies-online.com

Showing 10 out of 60 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-SHB Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: HepG2 cell lysate WB Suggested Anti-SHB  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.12500  Positive Control: HepG2 cell lysate  SHB is supported by BioGPS gene expression data to be expressed in HepG2 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-SHB Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated ELISA, WB   100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated WB Western blot analysis of SHB (pY246) expression in K562 (A), HepG2 (B) whole cell lysates. 200 μL Log in to see 9 Days
$575.00
Details
Human Rabbit Un-conjugated WB TMPPE Antibody (Center)  western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the TMPPE antibody detected the TMPPE protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Biotin ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Rabbit Un-conjugated ELISA   100 μL Log in to see 8 to 10 Days
$383.17
Details
Human Rabbit Un-conjugated WB SHB antibody used at 1 ug/ml to detect target protein. 50 μg Log in to see 3 to 4 Days
$473.93
Details
Human Rabbit Un-conjugated WB   100 μL Log in to see 8 to 10 Days
$522.50
Details

SHB Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , , , ,
, , ,
,
, , , , ,
Rat (Rattus)


Mouse (Murine) ,


,

Top referenced anti-SHB Antibodies

  1. Human Polyclonal SHB Primary Antibody for ELISA, WB - ABIN1451625 : Welsh, Mares, Karlsson, Lavergne, Bréant, Claesson-Welsh: Shb is a ubiquitously expressed Src homology 2 protein. in Oncogene 1994 (PubMed)
    Show all 2 references for ABIN1451625

  2. Human Polyclonal SHB Primary Antibody for WB - ABIN2787817 : Kriz, Agren, Lindholm, Lenell, Saldeen, Mares, Welsh: The SHB adapter protein is required for normal maturation of mesoderm during in vitro differentiation of embryonic stem cells. in The Journal of biological chemistry 2006 (PubMed)

More Antibodies against SHB Interaction Partners

Pig (Porcine) Src Homology 2 Domain Containing Adaptor Protein B (SHB) interaction partners

  1. Shb binds to tyrosine 1175 in the VEGFR-2 (show KDR Antibodies), which regulates VEGF (show VEGFA Antibodies)-induced formation of focal adhesions and cell migration, of which the latter occurs in a phosphatidylinositol 3-kinase-dependent manner [shb]

Human Src Homology 2 Domain Containing Adaptor Protein B (SHB) interaction partners

  1. SHB plays a role in integrating adaptive responses to various stimuli by simultaneously modulating cellular responses in different cell-types. [review]

  2. SH2-Bbeta is a Rac (show AKT1 Antibodies)-binding protein that regulates cell motility

  3. Shb links SLP-76 (show LCP2 Antibodies) and Vav (show VAV1 Antibodies) with the CD3 (show CD3 Antibodies) complex in Jurkat T cells (SLP-76 (show LCP2 Antibodies))

  4. SHB links IL2 (show IL2 Antibodies) receptor for signal transduction and mediates apoptosis

  5. Taken together, our results suggest that SH2-Bbeta is a new signaling molecule involved in GDNF (show GDNF Antibodies)-induced neurite outgrowth.

  6. It is concluded that SHB and angiogenic factors promote the development of cells expressing PDX-1 (show PDX1 Antibodies) and insulin (show INS Antibodies) in EBs and that such cells can be separated by FACS.

Mouse (Murine) Src Homology 2 Domain Containing Adaptor Protein B (SHB) interaction partners

  1. The observed aberrations in myeloid cell properties in Shb-deficient mice are likely consequences of an abnormal vascular compartment and are not responsible for reduced muscle blood flow

  2. a unique combinatorial response of increased vascular permeability and reduced recruitment of cytotoxic CD8 (show CD8A Antibodies)+ cells occurs as a consequence of Shb deficiency in B16F10 melanomas.

  3. Data indicate that Src homology-2 domain containing protein B (SHB) deficiency causes a chronic increase in beta-cell focal adhesion kinase (FAK) activity that perturbs the normal insulin secretory characteristics of beta-cells.

  4. Data suggest that absence of Src homology-2 protein Shb accelerates disease progression by exerting dual roles in BCR-ABL-induced leukemia: increased cell expansion due to elevated focal adhesion kinase (FAK) activity and neutrophilia in peripheral blood.

  5. loss of Shb alters TCR signalling ability, thereby favouring the development of Th2-driven inflammation and exacerbating symptoms of allergy

  6. Shb knockout mouse exhibited structural and functional (angiogenesis and vascular permeability) vascular abnormalities that have implications for understanding the function of VEGF-A (show VEGFA Antibodies) under physiological conditions

  7. Data show reduced VEGF-A (show VEGFA Antibodies) expression in Shb-deficient tumors.Interference with Shb signaling may provide novel means for future cancer therapy.

  8. Shb appears to play an important modulating role on T- Cell receptor signaling, thus regulating the peripheral CD4 (show CD4 Antibodies)+ T(H)2 cell response.

  9. It is concluded that SHB regulates normal oocyte and follicle development and that perturbation of SHB signaling causes defective meiosis I and early embryo development

  10. Shb binds directly to FAK (show PTK2 Antibodies) and regulates its phosphorylation leading to enhanced cell spreading in a Src (show SRC Antibodies)-dependent manner.

SHB Antigen Profile

Protein Summary

Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic- FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells.

Gene names and symbols associated with SHB

  • Src homology 2 domain containing adaptor protein B (SHB) antibody
  • Src homology 2 domain containing adaptor protein B (LOC100338867) antibody
  • Src homology 2 domain containing adaptor protein B (Shb) antibody
  • src homology 2 domain-containing transforming protein B (Shb) antibody
  • bA3J10.2 antibody
  • BC028832 antibody
  • RGD1565350 antibody
  • RP11-3J10.8 antibody
  • SHB antibody

Protein level used designations for SHB

Src homology 2 domain containing adaptor protein B , SH2 domain-containing adapter protein B-like , SH2 domain-containing adapter protein B , SHB (Src homology 2 domain containing) adaptor protein B , SHB adaptor protein (a Src homology 2 protein)

GENE ID SPECIES
427280 Gallus gallus
465107 Pan troglodytes
100013875 Monodelphis domestica
100153587 Sus scrofa
100338867 Oryctolagus cuniculus
100451365 Pongo abelii
100478715 Ailuropoda melanoleuca
6461 Homo sapiens
538275 Bos taurus
362513 Rattus norvegicus
230126 Mus musculus
481619 Canis lupus familiaris
Selected quality suppliers for anti-SHB (SHB) Antibodies
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