Src-Like-Adaptor Proteins (SLA)

Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl- tRNA(Sec) required for selenoprotein biosynthesis (By similarity).. Additionally we are shipping Src-Like-Adaptor Antibodies (21) and Src-Like-Adaptor Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SLA 211006 Q6P6M7
Rat SLA SLA 338477 P59622
SLA 6503 Q13239
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Top Src-Like-Adaptor Proteins at

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
HOST_Escherichia coli (E. coli) Human His tag Validation with Western Blot 50 μg Log in to see 6 to 10 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 2 to 3 Days

SLA Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,

More Proteins for Src-Like-Adaptor (SLA) Interaction Partners

Mouse (Murine) Src-Like-Adaptor (SLA) interaction partners

  1. SLAP and SLAP2 are critical inhibitors of platelet (hem)ITAM signaling in the setting of arterial thrombosis and ischemic stroke

  2. SLAP is a critical regulator of B-cell development and function and its deficiency leads to decreased autoreactive B cells that are otherwise maintained by inefficient receptor editing or failed negative selection.

  3. Src-like adaptor protein (SLAP) functions as a negative regulator of the granulocyte-macrophage colony-stimulating factor receptor (show CSF2RA Proteins) (GM-CSFR (show CSF2RA Proteins)) generation of monocyte-derived dendritic cells of bone marrow origin.

  4. SLAP deficiency dramatically reduces both the incidence and severity of arthritis and prevents development of chronic arthritis in the double SKG (mutant ZAP70 (show ZAP70 Proteins)) Src-like adapter protein (SLAP) knockout mouse model.

  5. SLAP negatively regulates differentiation of osteoclasts and proliferation of their precursors.

  6. SLAP functions in a pathway that requires the phosphorylated TCRzeta (show CD247 Proteins) chain and the Src (show SRC Proteins) family kinase Lck (show LCK Proteins), but not ZAP-70 (show ZAP70 Proteins) (zeta-associated protein of 70 kD).

  7. SLAP has a conserved function in B and T cells by adapting c-Cbl (show CBL Proteins) to the antigen-receptor complex and targeting it for degradation

  8. SECp43 and SLA (show HEPH Proteins) have roles in selenoprotein synthesis [soluble liver antigen]

Zebrafish Src-Like-Adaptor (SLA) interaction partners

  1. overexpression of SLalpha and SLbeta enhanced transcription of IGFs, insulin (show INS Proteins), leptin (show LEP Proteins), sterol regulatory element binding protein 1 (show SREBF1 Proteins), and fatty acid synthase (show FASN Proteins), as well as expression of vitellogenin and proopiomelanocortin (show POMC Proteins) in transgenic larvae

Human Src-Like-Adaptor (SLA) interaction partners

  1. results suggest that cytoplasm-specific transduction of the SH3 and SH2 domains of SLAP has a therapeutic potential of being an immunosuppressive reagent for the treatment of various autoimmune diseases

  2. Taken together the data demonstrate that SLAP negatively regulates wild-type c-Kit signaling, but not its oncogenic counterpart, indicating a possible mechanism by which the oncogenic c-Kit bypasses the normal cellular negative feedback control

  3. upon ligand stimulation SLAP stably associates with Flt3 (show FLT3 Proteins) through multiple phosphotyrosine residues in Flt3 (show FLT3 Proteins). SLAP mRNA is differentially expressed in different cancers and its expression significantly increased in patients carrying the Flt3 (show FLT3 Proteins)-ITD mutation

  4. These data provide evidence for src-like adaptor protein-dependent regulation of CD3 zeta-chain in the fine control of TCR signaling.

  5. Although SLA is a prominent glucocorticoids response gene, it does not seem to contribute to the anti-leukemic effects of glucocorticoids.

  6. The SLA molecule and its functionally relevant residues have been highly conserved throughout the evolution.

Src-Like-Adaptor (SLA) Protein Profile

Protein Summary

Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl- tRNA(Sec) required for selenoprotein biosynthesis (By similarity).

Gene names and symbols associated with Src-Like-Adaptor Proteins (SLA)

  • Src-like-adaptor (SLA)
  • Src-like-adaptor (LOC100223615)
  • Src-like-adaptor (LOC100339379)
  • Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase (Sepsecs)
  • somatolactin alpha (smtla)
  • src-like adaptor (Sla)
  • 9130208G10 protein
  • AA986712 protein
  • D5Ertd135e protein
  • SecS protein
  • sla protein
  • SLA1 protein
  • SLAP protein
  • Slap-1 protein
  • Slap1 protein
  • src-like-adapter protein

Protein level used designations for Src-Like-Adaptor Proteins (SLA)

Src-like-adaptor , O-phosphoseryl-tRNA(Sec) selenium transferase , UGA suppressor tRNA-associated protein , sec synthase , selenocysteine synthase , selenocysteinyl-tRNA(Sec) synthase , sep-tRNA:Sec-tRNA synthase , SLAP-1 , src-like-adapter , src-like-adapter protein 1 , mSLAP , src-like adapter protein , src-like adaptor protein , hSLAP , src-like adaptor

697377 Macaca mulatta
100223615 Taeniopygia guttata
100339379 Oryctolagus cuniculus
211006 Mus musculus
572522 Danio rerio
338477 Rattus norvegicus
20491 Mus musculus
6503 Homo sapiens
378908 Gallus gallus
608259 Canis lupus familiaris
513589 Bos taurus
464409 Pan troglodytes
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