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Cholesterol homeostasis is regulated, at least in part, by sterol regulatory element (SRE)-binding proteins (e.g., SREBP1\; MIM 184756) and by liver X receptors (e.g., LXRA\; MIM 602423). Additionally we are shipping STARD6 Antibodies (21) and many more products for this protein.
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Genetic association study results suggest that STARD6 is involved in the pathogenesis of Alzheimer's disease
Studies show the 3 steroidogenic acute regulatory-related lipid transfer (START) domain proteins StarD4 (show STARD4 Proteins), StarD5 (show STARD5 Proteins) and StarD6 have a similar lipid binding pocket specific for sterols (cholesterol in particular), but differing regulation and localization.
StARD6, which is expressed only in male germ-line cells, thus exhibits biological and biophysical properties that imply a role in steroidogenesis.
Cholesterol homeostasis is regulated, at least in part, by sterol regulatory element (SRE)-binding proteins (e.g., SREBP1\; MIM 184756) and by liver X receptors (e.g., LXRA\; MIM 602423). Upon sterol depletion, LXRs are inactive and SREBPs are cleaved, after which they bind promoter SREs and activate genes involved in cholesterol biosynthesis and uptake. Sterol transport is mediated by vesicles or by soluble protein carriers, such as steroidogenic acute regulatory protein (STAR\; MIM 600617). STAR is homologous to a family of proteins containing a 200- to 210-amino acid STAR-related lipid transfer (START) domain, including STARD6 (Soccio et al., 2002
START domain containing 6
, START domain-containing protein 6
, stAR-related lipid transfer protein 6
, START domain containing protein 6