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The protein encoded by STMN3 belongs to the stathmin/oncoprotein 18 family of microtubule-destabilizing phosphoproteins. Additionally we are shipping Stathmin 3 Antibodies (50) and Stathmin 3 Proteins (15) and many more products for this protein.
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our findings demonstrate that SCLIP plays an important role in glioma pathology, and may represent a novel therapeutic strategy against human glioma.
Overexpression of ID1 (show ID1 ELISA Kits) in two different cell lines induced STMN3 and GSPT1 at the transcriptional level, while depletion of ID1 (show ID1 ELISA Kits) reduced their expression.
STMN and SCG10 (show STMN2 ELISA Kits) are similarly targeted by JNK (show MAPK8 ELISA Kits) but there are clear differences in JNK (show MAPK8 ELISA Kits) recognition and phosphorylation of the closely related family member, SCLIP.
We found that reduced expression and possibly posttranslational modification of SCLIP following paclitaxel treatment impaired the microtubule-destabilizing effect of SCLIP
Specific serine-proline phosphorylation and glycogen synthase kinase 3beta-directed subcellular targeting of stathmin 3/Sclip in neurons
Studies suggest that a STAT3 (show STAT3 ELISA Kits)-SCLIP interaction is required to preserve SCLIP stability and contributes to the maintenance of normal epithelial morphology.
The substantial expression of SCLIP in most tissues points out a novel function outside the nervous system and raises the possibility that its coexpression with stathmin (show STMN1 ELISA Kits) could provide some degree of functional redundancy.
SCLIP and SCG10 (show STMN2 ELISA Kits) were colocalized to the Golgi apparatus of chromaffin cells in vivo and shared localization with CHGA (show CHGA ELISA Kits) as it transited the Golgi.
The determined the genomic and promoter structures of the SCLIP gene, and found that the gene retained an NRS (show SPNS1 ELISA Kits)-like element that functioned as a negative regulator in non-neuronal cells.
a physical and functional interaction between RasGRF1 (show RASGRF1 ELISA Kits) and SCLIP; this novel interplay may have possible implications in mechanisms that regulate neuronal morphology and structural plasticity
This gene encodes a protein which is a member of the stathmin protein family. Members of this protein family form a complex with tubulins at a ratio of 2 tubulins for each stathmin protein. Microtubules require the ordered assembly of alpha- and beta-tubulins, and formation of a complex with stathmin disrupts microtubule formation and function. A pseudogene of this gene is located on chromosome 22. Alternative splicing results in multiple transcript variants.
, SCG10-related protein HiAT3
, Scgn10 like-protein
, hippocampus abundant transcript 3
, scgn10 like-protein