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Staufen, RNA Binding Protein, Homolog 2 (Drosophila) Proteins (STAU2)

Staufen homolog 2 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles.

list all proteins Gene Name GeneID UniProt
Mouse STAU2 STAU2 29819 Q8CJ67
Human STAU2 STAU2 27067 Q9NUL3
Rat STAU2 STAU2 171500 Q68SB1
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More Proteins for Staufen, RNA Binding Protein, Homolog 2 (Drosophila) (STAU2) Interaction Partners

Cow (Bovine) Staufen, RNA Binding Protein, Homolog 2 (Drosophila) (STAU2) interaction partners

  1. STAU1 (show STAU1 Proteins) & STAU2 & ELAVL1 (show ELAVL1 Proteins) mRNAs & proteins were detected throughout cow preimplantation development (show MTA2 Proteins) from the germinal vesicle (GV) oocyte to the blastocyst stage; ELAVL2 (show ELAVL2 Proteins) mRNAs were detectable from the GV to the morula stage; ELAVL2 (show ELAVL2 Proteins) protein was in all stages

Mouse (Murine) Staufen, RNA Binding Protein, Homolog 2 (Drosophila) (STAU2) interaction partners

  1. Stau2 is distributed asymmetrically during progenitor divisions in the developing mouse cortex, preferentially segregating into the Tbr2 (show EOMES Proteins)( ) neuroblast daughter, taking with it a subset of RNAs.

  2. Data show that Stau2 is localized to the neuronal soma and dendrites, but it does not colocalize with Stau1 (show STAU1 Proteins)-containing particles.

  3. zinc finger RNA binding protein is a native component of Staufen2-containing granules and likely plays its role during early steps of RNA transport and localization

Human Staufen, RNA Binding Protein, Homolog 2 (Drosophila) (STAU2) interaction partners

  1. Authors establish that human Staufen-2, a host factor which is up-regulated upon HIV-1 infection, interacts with HIV-1 Rev, thereby promoting its RNA export activity and progeny virus formation.

  2. Staufen2 functions in Staufen1-mediated mRNA decay by binding to itself and its paralog and promoting UPF1 helicase but not ATPase activity.

  3. We suggest a role for Stau2 in the generation and regulation of Map1b mRNA containing granules that are required for mGluR (show GRM8 Proteins)-long-term depression

  4. Data show that Stau2 is localized to the neuronal soma and dendrites, but it does not colocalize with Stau1 (show STAU1 Proteins)-containing particles.

  5. Stau1 (show STAU1 Proteins)- and Stau2-mRNPs associate with distinct but overlapping sets of cellular mRNAs.

Zebrafish Staufen, RNA Binding Protein, Homolog 2 (Drosophila) (STAU2) interaction partners

  1. stau2 is required for the survival and migration of primoridal germ cells.

Staufen, RNA Binding Protein, Homolog 2 (Drosophila) (STAU2) Protein Profile

Protein Summary

Staufen homolog 2 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. Staufen homolog 2 shares 48.5% and 59.9% similarity with drosophila and human staufen, respectively. The exact function of Staufen homolog 2 is not known, but since it contains 3 copies of conserved dsRNA binding domain, it could be involved in double-stranded RNA binding events. Several transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with STAU2

  • staufen, RNA binding protein, homolog 2 (Drosophila) (STAU2)
  • staufen, RNA binding protein, homolog 2 (Drosophila) (stau2-a)
  • staufen (RNA binding protein) homolog 2 (Drosophila) (Stau2)
  • staufen double-stranded RNA binding protein 2 (STAU2)
  • staufen double-stranded RNA binding protein 2 (Stau2)
  • staufen, RNA binding protein, homolog 2 (Drosophila) (stau2)
  • 39K2 protein
  • 39K3 protein
  • DKFZp459N0230 protein
  • MGC53791 protein
  • STAU2 protein
  • stau2-a protein
  • zgc:55287 protein

Protein level used designations for STAU2

double-stranded RNA-binding protein Staufen homolog 2 , staufen homolog 2 , staufen, RNA binding protein, homolog 2 , staufen, RNA binding protein, homolog 2 (Drosophila) , double-stranded RNA-binding protein Staufen homolog 2-like , staufen 2 , r-staufen protein

GENE ID SPECIES
100125233 Bos taurus
380477 Xenopus laevis
420184 Gallus gallus
464233 Pan troglodytes
696034 Macaca mulatta
100171762 Pongo abelii
100340385 Oryctolagus cuniculus
100409920 Callithrix jacchus
29819 Mus musculus
27067 Homo sapiens
171500 Rattus norvegicus
477913 Canis lupus familiaris
393899 Danio rerio
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