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Staufen homolog 2 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and\\/or localization of mRNAs to different subcellular compartments and\\/or organelles.
STAU1 (show STAU1 ELISA Kits) & STAU2 & ELAVL1 (show ELAVL1 ELISA Kits) mRNAs & proteins were detected throughout cow preimplantation development (show MTA2 ELISA Kits) from the germinal vesicle (GV) oocyte to the blastocyst stage; ELAVL2 (show ELAVL2 ELISA Kits) mRNAs were detectable from the GV to the morula stage; ELAVL2 (show ELAVL2 ELISA Kits) protein was in all stages
Stau2 is required for spindle formation and timely meiotic progression in mouse oocytes.
Stau2 is distributed asymmetrically during progenitor divisions in the developing mouse cortex, preferentially segregating into the Tbr2 (show EOMES ELISA Kits)( ) neuroblast daughter, taking with it a subset of RNAs.
Data show that Stau2 is localized to the neuronal soma and dendrites, but it does not colocalize with Stau1 (show STAU1 ELISA Kits)-containing particles.
zinc finger RNA binding protein (show ZFR ELISA Kits) is a native component of Staufen2-containing granules and likely plays its role during early steps of RNA transport and localization
during genotoxic stress, Stau2 is downregulated at the promoter level in an ATR (show ANTXR1 ELISA Kits)- and E2F1 (show E2F1 ELISA Kits)-dependent manner, leading to increased levels of DNA damage and apoptosis.
Authors establish that human Staufen-2, a host factor which is up-regulated upon HIV-1 infection, interacts with HIV-1 Rev, thereby promoting its RNA export activity and progeny virus formation.
Staufen2 functions in Staufen1 (show STAU1 ELISA Kits)-mediated mRNA decay by binding to itself and its paralog and promoting UPF1 (show UPF1 ELISA Kits) helicase but not ATPase (show DNAH8 ELISA Kits) activity.
We suggest a role for Stau2 in the generation and regulation of Map1b (show MAP1B ELISA Kits) mRNA containing granules that are required for mGluR (show GRM8 ELISA Kits)-long-term depression
Stau1 (show STAU1 ELISA Kits)- and Stau2-mRNPs associate with distinct but overlapping sets of cellular mRNAs.
stau2 is required for the survival and migration of primoridal germ cells.
Staufen homolog 2 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. Staufen homolog 2 shares 48.5% and 59.9% similarity with drosophila and human staufen, respectively. The exact function of Staufen homolog 2 is not known, but since it contains 3 copies of conserved dsRNA binding domain, it could be involved in double-stranded RNA binding events. Several transcript variants encoding different isoforms have been found for this gene.
double-stranded RNA-binding protein Staufen homolog 2
, staufen homolog 2
, staufen, RNA binding protein, homolog 2
, staufen, RNA binding protein, homolog 2 (Drosophila)
, double-stranded RNA-binding protein Staufen homolog 2-like
, staufen 2
, r-staufen protein