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anti-Stem-Loop Binding Protein (SLBP) Antibodies

SLBP encodes a protein that binds to the stem-loop structure in replication-dependent histone mRNAs. Additionally we are shipping SLBP Proteins (5) and SLBP Kits (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SLBP 681062  
SLBP 7884 Q14493
SLBP 20492 P97440
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Top anti-SLBP Antibodies at antibodies-online.com

Showing 10 out of 18 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-SLBP Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: HepG2 cell lysate Rabbit Anti-SLBP Antibody ,Paraffin Embedded Tissue: Human Bronchial Epithelial Tissue 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated IF, WB Immunofluorescence of monoclonal antibody to SLBP on HeLa cell.[antibody concentration 10 µg/mL] SLBP monoclonal antibody (M01), clone 2C4-1C8 Western Blot analysis of SLBP expression in Hela NE. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Mouse Un-conjugated IF, ELISA, WB Immunofluorescence of monoclonal antibody to SLBP on HeLa cell. [antibody concentration 10 ug/ml] SLBP monoclonal antibody (M01), clone 2C4-1C8 Western Blot analysis of SLBP expression in Hela S3 NE . 100 μg Log in to see 9 Days
$430.00
Details
Dog Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Un-conjugated WB SLBP antibody used at 0.25 ug/ml to detect target protein. 50 μg Log in to see 3 to 4 Days
$473.93
Details
Human Mouse Alkaline Phosphatase (AP) ICC, ELISA, WB   100 μL Log in to see 8 to 10 Days
$925.83
Details
Human Mouse Biotin ICC, ELISA, WB   100 μL Log in to see 8 to 10 Days
$925.83
Details
Human Mouse APC ICC, ELISA, WB   100 μL Log in to see 8 to 10 Days
$925.83
Details
Human Mouse PE ICC, ELISA, WB   100 μL Log in to see 8 to 10 Days
$925.83
Details

SLBP Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Rat (Rattus)


Human ,
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Mouse (Murine)


Top referenced anti-SLBP Antibodies

  1. Human Monoclonal SLBP Primary Antibody for IF, WB - ABIN394132 : Sullivan, Mullen, Marzluff, Wagner: Knockdown of SLBP results in nuclear retention of histone mRNA. in RNA (New York, N.Y.) 2009 (PubMed)
    Show all 5 references for ABIN394132

  2. Chicken Polyclonal SLBP Primary Antibody for WB - ABIN2778993 : Borchers, Thapar, Petrotchenko, Torres, Speir, Easterling, Dominski, Marzluff: Combined top-down and bottom-up proteomics identifies a phosphorylation site in stem-loop-binding proteins that contributes to high-affinity RNA binding. in Proceedings of the National Academy of Sciences of the United States of America 2006 (PubMed)

  3. Human Monoclonal SLBP Primary Antibody for IF, ELISA - ABIN563497 : Tan, Hagen: Destabilization of CDC6 upon DNA damage is dependent on neddylation but independent of Cullin E3 ligases. in The international journal of biochemistry & cell biology 2013 (PubMed)

More Antibodies against SLBP Interaction Partners

Fruit Fly (Drosophila melanogaster) Stem-Loop Binding Protein (SLBP) interaction partners

  1. Although the C-terminal tail of dSLBP does not contact the RNA, phosphorylation of the tail promotes SLBP conformations competent for RNA binding and thereby appears to reduce the entropic penalty for the association.

  2. nuclear retention involves Chk2-mediated inactivation of the Drosophila stem loop binding protein (SLBP), the levels of which are specifically depleted in damaged nuclei following Chk2 phosphorylation, an event that contributes to nuclear fallout.

  3. The nuclear magnetic resonance and kinetic studies presented here provide a framework for understanding how SLBP recognizes histone mRNA and highlight possible structural roles of phosphorylation and proline isomerization in RNA binding proteins

  4. Slbp mutants display genomic instability, including loss of heterozygosity (LOH), increased presence of chromosome breaks, tetraploidy, and changes in position effect variegation (PEV).

  5. Developmental control of histone mRNA and dSLBP synthesis during Drosophila embryogenesis and the role of dSLBP in histone mRNA 3' end processing in vivo.

  6. Phosphorylation of T120 and T230 site of Stem-loop binding protein (SLBP) differentially affects the ability of the protein to restore viability and histone mRNA processing.

  7. characterize the structural and dynamic features of the N-terminal domain of SLBP from Drosophila

  8. electrostatic effect of protein phosphorylation can be partially mimicked by a mutant form of SLBP wherein four C-terminal serines are replaced with glutamic acids

  9. Removal of the phosphoryl group from T230 by either dephosphorylation or mutation results in a 7-fold reduction in the affinity of SLBP for the stem-loop RNA

Human Stem-Loop Binding Protein (SLBP) interaction partners

  1. arsenic, a carcinogenic metal, decreases cellular levels of SLBP by inducing its proteasomal degradation and inhibiting SLBP transcription via epigenetic mechanisms

  2. the S/G2 (show STRN3 Antibodies) stable mutant form of SLBP is degraded by proteasome in G1, indicating that indicating that the SLBP degradation in G1 is independent of the previously identified SLBP degradation at S/G2 (show STRN3 Antibodies)

  3. Although the C-terminal tail of dSLBP does not contact the RNA, phosphorylation of the tail promotes SLBP conformations competent for RNA binding and thereby appears to reduce the entropic penalty for the association.

  4. C-terminal extension of Lsm4 (show LSM4 Antibodies) interacts directly with the histone mRNP, contacting both SLBP and 3'hExo (show ERI1 Antibodies).

  5. This paper describes the biophysical characterization of human SLBP and the SLBP-SLIP1 (show MIF4GD Antibodies) complex. Human SLBP is an intrinsically disordered protein that is phosphorylated at 23 Ser (show SIGLEC1 Antibodies)/Thr (show TRH Antibodies) sites when expressed in a eukaryotic expression system such as baculovirus. Unphosphorylated human SLBP forms a high affinity heterotetramer with SLIP1 (show MIF4GD Antibodies) and the SLBP-SLIP1 (show MIF4GD Antibodies) complex is regulated by SLBP phosphorylation.

  6. Using yeast two-hybrid screening, the authors identify CT initiation factor-interacting protein (CTIF (show KIAA0427 Antibodies)) as a protein that binds directly to SLBP. SLBP preferentially associates with the CT complex of histone mRNAs consisting of CBP80 (show NCBP1 Antibodies)/CBP20 (show NCBP2 Antibodies), but not with the eIF4E (show EIF4E Antibodies)/eIF4G (show EIF4G1 Antibodies) (ET) complex, as has been proposed. Rapid degradation of histone mRNA on the inhibition of DNA replication requires association of SLBP with CTIF (show KIAA0427 Antibodies).

  7. This paper shows that SLBP is a substrate for the prolyl isomerase Pin1 (show PIN1 Antibodies). Pin1 (show PIN1 Antibodies), along with PP2A (show PPP2R4 Antibodies), facilitates dissociation of the SLBP-histone mRNA complex at the end of S-phase, thereby promoting histone mRNA decay and SLBP ubiquitination.

  8. the crystal structure of a ternary complex of human SLBP RNA binding domain, human 3'hExo (show ERI1 Antibodies), and a 26-nucleotide stem-loop RNA is reported.

  9. haploinsufficiency of SLBP and/or WHSC2 (NELF-A (show WHSC2 Antibodies)) contributes to several novel cellular phenotypes of WHS (show WHSC1 Antibodies).

  10. The nuclear magnetic resonance and kinetic studies presented here provide a framework for understanding how SLBP recognizes histone mRNA and highlight possible structural roles of phosphorylation and proline isomerization in RNA binding proteins

Mouse (Murine) Stem-Loop Binding Protein (SLBP) interaction partners

  1. During maturation, Slbp mRNA becomes polyadenylated and translationally activated. Proteasomal activity is required both to initiate and to sustain translational activation.

  2. SLBP expression and activity differ in mouse oocytes and early embryos compared with somatic cells.

  3. Inhibition of NF kappa B (show NFKB1 Antibodies) in TNF alpha (show TNF Antibodies)-treated primary mouse hepatocytes is associated with increased S-phase cell cycle retention and decreased stem loop binding protein.

  4. histone synthesis in immature and maturing oocytes is governed by a translational control mechanism that is directly regulated by changes in the amount of SLBP

  5. SLBP is an essential component of the mechanism by which growing oocytes of the mouse accumulate the histones that support early embryonic development.

  6. Maternally encoded Slbp is degraded in 2-cell mouse embryos by the co-ordinated activity of two separately regulated pathways.

Xenopus laevis Stem-Loop Binding Protein (SLBP) interaction partners

  1. SLBP is required for retinal stem cell maintenance. SLBP and Notch (show NOTCH1 Antibodies) signaling are required for retinal progenitor cell proliferation and subsequent neurogenesis.

  2. SLBP stimulates histone translation at an early step in the intiaition pathway.

SLBP Antigen Profile

Protein Summary

This gene encodes a protein that binds to the stem-loop structure in replication-dependent histone mRNAs. Histone mRNAs do not contain introns or polyadenylation signals, and are processed by endonucleolytic cleavage. The stem-loop structure is essential for efficient processing but this structure also controls the transport, translation and stability of histone mRNAs. Expression of the protein is regulated during the cell cycle, increasing more than 10-fold during the latter part of G1.

Gene names and symbols associated with SLBP

  • stem-loop binding protein (Slbp) antibody
  • Stem-loop binding protein (Slbp) antibody
  • stem-loop binding protein (slbp) antibody
  • stem-loop binding protein (SLBP) antibody
  • histone RNA hairpin-binding protein (Slbp) antibody
  • histone RNA hairpin-binding protein (EHI_178590) antibody
  • histone RNA hairpin-binding protein (CpipJ_CPIJ008644) antibody
  • histone RNA hairpin-binding protein (slbp) antibody
  • cb157 antibody
  • CG11886 antibody
  • Dmel\\CG11886 antibody
  • dSLBP antibody
  • dSLPB antibody
  • GB13630 antibody
  • HBP antibody
  • sb:cb157 antibody
  • si:dkey-102m7.2 antibody
  • slbp antibody
  • slbp1 antibody
  • xslbp antibody

Protein level used designations for SLBP

histone RNA hairpin-binding protein , CG11886-PA , Slbp-PA , stem loop binding protein , RNA processing protein , histone stem-loop binding protein , stem-loop (histone) binding protein , RNA binding protein , histone stem loop binding protein , hairpin binding protein, histone , histone binding protein , histone stem-loop-binding protein , histone stem-loop-binding protein 1

GENE ID SPECIES
681062 Rattus norvegicus
43448 Drosophila melanogaster
407727 Danio rerio
422902 Gallus gallus
488810 Canis lupus familiaris
444868 Bos taurus
726745 Apis mellifera
3410556 Entamoeba histolytica HM-1:IMSS
6040883 Culex quinquefasciatus
8626522 Dictyostelium discoideum AX4
7884 Homo sapiens
20492 Mus musculus
398073 Xenopus laevis
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