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ZAK is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM).
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Gene set enrichment analysis disclosed a significant correlation between ZAK+ colorectal premalignant lesions and gene sets belonging to the MAPK/ERK (show MAPK1 Antibodies) and motility-related signaling pathways of the reactome database, strongly suggesting that ZAK induces such pro-tumoral reaction cascades in human cancers.
Recessive mutations in the kinase ZAK - novel cause of congenital myopathy.
ZAK is a key player in mammalian limb patterning in humans and mice.
ZAK kinase isoform TV1 is preferentially upregulated in gastric tumours and cell lines relative to normal samples. This pattern is also observed in colorectal, bladder and breast cancers.
The long non-coding RNA URHC promotes cell proliferation and inhibits apoptosis by repressing ZAK expression through inactivation of the ERK/MAPK (show MAPK1 Antibodies) pathway.
we report that sorafenib suppresses UV-induced apoptosis specifically by inhibiting c-jun (show JUN Antibodies)-NH(2)-kinase (JNK (show MAPK8 Antibodies)) activation through the off-target inhibition of leucine zipper and sterile alpha motif-containing kinase (ZAK)
MRK (show ICK Antibodies) is a novel RhoC (show RHOC Antibodies) effector that controls LPA (show APOA Antibodies)-stimulated cell invasion at least in part by regulating myosin dynamics, ERK (show EPHB2 Antibodies) and p38 (show CRK Antibodies)
The genes identified KTN1 (show KTN1 Antibodies), ROCK1 (show ROCK1 Antibodies), and ZAK may be responsible for loss of cellular homeostasis in giant cells tumors of bone
decrease of lung cancer cell proliferation by ZAK may involve the ERK (show EPHB2 Antibodies) and JNK (show MAPK8 Antibodies) pathways via an AP-1 (show FOSB Antibodies) transcription factor.
In this study, by applying a novel method, we have identified the phosphorylation sites in human MSK1 mitogen- and stress-activated protein kinase 1 (show RPS6KA5 Antibodies), and show that MRK (show ICK Antibodies)-beta could also activate MSK1 (show RPS6KA5 Antibodies) through direct interaction.
This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
mitogen-activated protein kinase kinase kinase MLT
, sterile alpha motif and leucine zipper containing kinase AZK
, MLK-related kinase
, MLK-like mitogen-activated protein triple kinase
, human cervical cancer suppressor gene 4 protein
, mixed lineage kinase 7
, mixed lineage kinase with a leucine zipper and a sterile alpha motif
, mixed lineage kinase-related kinase MRK-beta