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anti-Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) (SRD5A2) Antibodies

SRD5A2 encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. Additionally we are shipping Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) Kits (15) and Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SRD5A2 94224 Q99N99
SRD5A2 6716 P31213
SRD5A2 64677 P31214
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Top anti-Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) Antibodies at antibodies-online.com

Showing 10 out of 62 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC, WB WB Suggested Anti-SRD5A2 Antibody Titration: 0.2-1 ug/mlPositive Control: THP-1 cell lysate Sample Type: Monkey adrenal gland Primary Antibody Dilution: 1:25Secondary Antibody: Anti-rabbit-HRP Secondary Antibody Dilution: 1:5000 Color/Signal Descriptions: Brown: SRD5A2 Blue: Nucleus  Gene Name: SRD5A2 Submitted by: Jonathan Bertin, Endoceutics Inc. 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Goat Un-conjugated WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Dog Goat Un-conjugated WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Goat Un-conjugated ELISA, WB ABIN185347 (0.3µg/ml) staining of human testes lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 4 to 5 Days
$318.20
Details
Human Rabbit Un-conjugated WB Lanes: Lane 1:541 µg monkey brain extract Primary Antibody Dilution: 1:0000Secondary Antibody: Goat anti rabbit-HRP Secondary Antibody Dilution: 1:00,000  Gene Name: SRD5A2 Submitted by: Jonathan Bertin, Endoceutics Inc. 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated ELISA, WB Detection limit for recombinant GST tagged SRD5A2 is 0.03 ng/ml as a capture antibody. Western Blot detection against Immunogen (29.81 KDa) . 100 μg Log in to see 9 Days
$430.00
Details
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (30.18 KDa) . 50 μL Log in to see 9 Days
$298.57
Details
Human Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Un-conjugated WB SRD5A2 Antibody (Center) (ABIN651742) western blot analysis in mouse kidney tissue lysates (15 µg/lane). This demonstrates the SRD5A2 antibody detected SRD5A2 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$433.13
Details

SRD5A2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine)


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Top referenced anti-Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) Antibodies

  1. Human Monoclonal SRD5A2 Primary Antibody for ELISA, WB - ABIN520465 : Sato, Iemitsu, Matsutani, Kurihara, Hamaoka, Fujita: Resistance training restores muscle sex steroid hormone steroidogenesis in older men. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014 (PubMed)

  2. Human Polyclonal SRD5A2 Primary Antibody for ELISA, WB - ABIN562991 : Park, Aizawa, Iemitsu, Sato, Akimoto, Agata, Maeda, Ezawa, Omi: DHEA administration activates local bioactive androgen metabolism in cancellous site of tibia of ovariectomized rats. in Calcified tissue international 2011 (PubMed)

  3. Human Polyclonal SRD5A2 Primary Antibody for IHC, WB - ABIN2781788 : Bertin, Dury, Ouellet, Pelletier, Labrie: Localization of the Androgen-Synthesizing Enzymes, Androgen Receptor, and Sex Steroids in the Vagina: Possible Implications for the Treatment of Postmenopausal Sexual Dysfunction. in The journal of sexual medicine 2014 (PubMed)

  4. Human Polyclonal SRD5A2 Primary Antibody for ELISA, WB - ABIN185347 : Iczkowski, Qiu, Qian, Somerville, Rittmaster, Andriole, Bostwick: The dual 5-alpha-reductase inhibitor dutasteride induces atrophic changes and decreases relative cancer volume in human prostate. in Urology 2005 (PubMed)

  5. Human Polyclonal SRD5A2 Primary Antibody for WB - ABIN374517 : Vu, Hirst, Stark, Wright, Palliser, Hodyl, Clifton: Changes in human placental 5alpha-reductase isoenzyme expression with advancing gestation: effects of fetal sex and glucocorticoid exposure. in Reproduction, fertility, and development 2009 (PubMed)

  6. Dog (Canine) Polyclonal SRD5A2 Primary Antibody for WB - ABIN375127 : Torkko, van Bokhoven, Mai, Beuten, Balic, Byers, Hokanson, Norris, Barón, Lucia, Thompson, Leach: VDR and SRD5A2 polymorphisms combine to increase risk for prostate cancer in both non-Hispanic White and Hispanic White men. in Clinical cancer research : an official journal of the American Association for Cancer Research 2008 (PubMed)

More Antibodies against Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) Interaction Partners

Mouse (Murine) Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) (SRD5A2) interaction partners

  1. observed an abnormally high expression levels of type 2 5alpha-reductase and 20alpha-HSD in the male and female adrenals, respectively, thus indirectly suggesting new roles for these sex-specific enzymes

  2. The induction of Srd5a2 through SREBP-2 (show SREBF2 Antibodies) provides a mechanistic explanation for why even though statin therapy is effective in reducing cholesterol levels in treating hypercholesterolemia it does not compromise androgen production in clinical studies.

Human Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) (SRD5A2) interaction partners

  1. Results suggest that SRD5A2 controls cell migration by indirectly regulating ERK/MAPK (show MAPK1 Antibodies) pathway in prostate cancer cells.

  2. Metabolic syndrome develops more frequently in testicular cancer survivors homozygous or heterozygous variant for SNP rs523349 in SRD5A2.

  3. the V89L and TA repeat polymorphisms of SRD5A2 gene were found to have no significant associations with breast cancer

  4. the genotypic distribution of 22 single nucleotide polymorphisms in SRD5A1 (show SRD5A1 Antibodies) and SRD5A2 in a set of Spanish prostate cancer patients, were evaluated.

  5. In prostate cancer, increased DNA methylation (show HELLS Antibodies) of SRD5A2 and CYP11A1 (show CYP11A1 Antibodies) related to androgen biosynthesis functions may play a role in biochemical recurrence after patients' prostatectomy

  6. SRD5A2 gene polymorphisms are associated with the risk of benign prostatic hyperplasia but not prostate cancer.

  7. methylation of SRD5A2 is regulated by DNA methyltransferase 1 (show DNMT1 Antibodies), and inflammatory mediators such as tumor necrosis factor alpha (show TNF Antibodies), NF-kappaB (show NFKB1 Antibodies), and IL-6 (show IL6 Antibodies) regulate DNA methyltransferase 1 (show DNMT1 Antibodies) expression and thereby affect SRD5A2 promoter methylation and gene expression.

  8. High 5alpha-reductase activity due to the polymorphism in SRD5A2 may contribute to resistance to androgen deprivation therapy.

  9. Manipulation of SRD5A2 activity can regulate lipogenesis in human hepatocytes in vitro.

  10. Expression of the genes HSD3B1 (show HSD3B1 Antibodies), HSD17B3 (show HSD17B3 Antibodies), and SRD5A2 was significantly increased in BPH (show GLI3 Antibodies) tissues compared to normal adjacent prostate tissues.

Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) (SRD5A2) Antigen Profile

Protein Summary

This gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH).

Gene names and symbols associated with SRD5A2

  • steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) (SRD5A2) antibody
  • steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) (srd5a2) antibody
  • steroid-5-alpha-reductase alpha polypeptide 2 (srd5a2) antibody
  • steroid 5 alpha-reductase 2 (Srd5a2) antibody
  • steroid 5-alpha-reductase 2 (ST5AR2) antibody
  • steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) (Srd5a2) antibody
  • 5ART2 antibody
  • S5AR 2 antibody
  • Srd5a2 antibody
  • SRD5alpha2 antibody

Protein level used designations for SRD5A2

3-oxo-5-alpha-steroid 4-dehydrogenase 2 , steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) , steroid-5-alpha-reductase alpha polypeptide 2 , 5 alpha-SR2 , SR type 2 , steroid 5 alpha reductase type2 , steroid 5-alpha-reductase 2 , S5AR 2 , type II 5-alpha reductase , prostatic steroid 5-alpha-reductase type II

GENE ID SPECIES
527024 Bos taurus
772291 Gallus gallus
549867 Xenopus (Silurana) tropicalis
705676 Macaca mulatta
100125532 Oryzias latipes
94224 Mus musculus
397048 Sus scrofa
6716 Homo sapiens
64677 Rattus norvegicus
403715 Canis lupus familiaris
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