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Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) Proteins (SRD5A2)

SRD5A2 encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. Additionally we are shipping Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) Antibodies (67) and Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) Kits (15) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SRD5A2 94224 Q99N99
SRD5A2 6716 P31213
Rat SRD5A2 SRD5A2 64677 P31214
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Top Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Wheat germ Human Un-conjugated   10 μg Log in to see 9 Days
$641.43
Details

SRD5A2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
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More Proteins for Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) (SRD5A2) Interaction Partners

Mouse (Murine) Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) (SRD5A2) interaction partners

  1. observed an abnormally high expression levels of type 2 5alpha-reductase and 20alpha-HSD in the male and female adrenals, respectively, thus indirectly suggesting new roles for these sex-specific enzymes

  2. The induction of Srd5a2 through SREBP-2 (show SREBF2 Proteins) provides a mechanistic explanation for why even though statin therapy is effective in reducing cholesterol levels in treating hypercholesterolemia it does not compromise androgen production in clinical studies.

Human Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) (SRD5A2) interaction partners

  1. Results suggest that SRD5A2 controls cell migration by indirectly regulating ERK/MAPK (show MAPK1 Proteins) pathway in prostate cancer cells.

  2. Metabolic syndrome develops more frequently in testicular cancer survivors homozygous or heterozygous variant for SNP rs523349 in SRD5A2.

  3. the V89L and TA repeat polymorphisms of SRD5A2 gene were found to have no significant associations with breast cancer

  4. the genotypic distribution of 22 single nucleotide polymorphisms in SRD5A1 (show SRD5A1 Proteins) and SRD5A2 in a set of Spanish prostate cancer patients, were evaluated.

  5. In prostate cancer, increased DNA methylation (show HELLS Proteins) of SRD5A2 and CYP11A1 (show CYP11A1 Proteins) related to androgen biosynthesis functions may play a role in biochemical recurrence after patients' prostatectomy

  6. SRD5A2 gene polymorphisms are associated with the risk of benign prostatic hyperplasia but not prostate cancer.

  7. methylation of SRD5A2 is regulated by DNA methyltransferase 1 (show DNMT1 Proteins), and inflammatory mediators such as tumor necrosis factor alpha (show TNF Proteins), NF-kappaB (show NFKB1 Proteins), and IL-6 (show IL6 Proteins) regulate DNA methyltransferase 1 (show DNMT1 Proteins) expression and thereby affect SRD5A2 promoter methylation and gene expression.

  8. High 5alpha-reductase activity due to the polymorphism in SRD5A2 may contribute to resistance to androgen deprivation therapy.

  9. Manipulation of SRD5A2 activity can regulate lipogenesis in human hepatocytes in vitro.

  10. Expression of the genes HSD3B1 (show HSD3B1 Proteins), HSD17B3 (show HSD17B3 Proteins), and SRD5A2 was significantly increased in BPH (show GLI3 Proteins) tissues compared to normal adjacent prostate tissues.

Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) (SRD5A2) Protein Profile

Protein Summary

This gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH).

Gene names and symbols associated with SRD5A2

  • steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) (SRD5A2)
  • steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) (srd5a2)
  • steroid-5-alpha-reductase alpha polypeptide 2 (srd5a2)
  • steroid 5 alpha-reductase 2 (Srd5a2)
  • steroid 5-alpha-reductase 2 (ST5AR2)
  • steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) (Srd5a2)
  • 5ART2 protein
  • S5AR 2 protein
  • Srd5a2 protein
  • SRD5alpha2 protein

Protein level used designations for SRD5A2

3-oxo-5-alpha-steroid 4-dehydrogenase 2 , steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) , steroid-5-alpha-reductase alpha polypeptide 2 , 5 alpha-SR2 , SR type 2 , steroid 5 alpha reductase type2 , steroid 5-alpha-reductase 2 , S5AR 2 , type II 5-alpha reductase , prostatic steroid 5-alpha-reductase type II

GENE ID SPECIES
527024 Bos taurus
772291 Gallus gallus
549867 Xenopus (Silurana) tropicalis
705676 Macaca mulatta
100125532 Oryzias latipes
94224 Mus musculus
397048 Sus scrofa
6716 Homo sapiens
64677 Rattus norvegicus
403715 Canis lupus familiaris
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