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anti-Steroidogenic Acute Regulatory Protein (STAR) Antibodies

The protein encoded by STAR plays a key role in the acute regulation of steroid hormone synthesis by enhancing the conversion of cholesterol into pregnenolone. Additionally we are shipping STAR Kits (21) and STAR Proteins (20) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
STAR 20845 P51557
STAR 25557 P97826
STAR 6770 P49675
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Top anti-STAR Antibodies at antibodies-online.com

Showing 10 out of 48 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis in SK-BR-3 cell line lysates (35ug/lane) using STAR / STARD1 Antibody (Center) Cat.-No  AP54065PU-N. This demonstrates the STAR antibody detected the STAR protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB ICC/IF Image StAR antibody detects StAR protein at mitochondria by immunofluorescent analysis. Sample: HepG2 cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: StAR protein stained by StAR antibody , diluted at 1:500. Blue: Hoechst 33342 staining. IHC-P Image StAR antibody detects StAR protein at cytosol on human hepatoma by immunohistochemical analysis. Sample: Paraffin-embedded hepatoma. StAR antibody , dilution: 1:500. 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Mouse Un-conjugated RNAi, ELISA, WB Western blot analysis of STAR over-expressed 293 cell line, cotransfected with STAR Validated Chimera RNAi (Lane 2) or non-transfected control (Lane 1). Blot probed with STAR monoclonal antibody (M01), clone 5F9. GAPDH ( 36.1 kDa ) used as specificity and loading control. Detection limit for recombinant GST tagged STAR is approximately 0.03ng/ml as a capture antibody. 100 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded mouse embryo labeled with Rabbit Anti StAR/StARD1 Polyclonal Antibody, Unconjugated (ABIN700960) at 1:200 followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded rat kidney labeled with Rabbit Anti StAR/StARD1 Polyclonal Antibody, Unconjugated (ABIN700960) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$269.50
Details
Human Rabbit Un-conjugated WB STAR Antibody (Center)  western blot analysis in SK-BR-3 cell line lysates (35ug/lane).This demonstrates the STAR antibody detected the STAR protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated WB Western Blot analysis of STAR expression in transfected 293T cell line by STAR monoclonal antibody (M01), clone 5F9. Lane 1: STAR transfected lysate(31.9 KDa). Lane 2: Non-transfected lysate. Western blot analysis of STAR over-expressed 293 cell line, cotransfected with STAR Validated Chimera RNAi used as specificity and loading control. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated IHC, WB 100 μL Log in to see 14 Days
$369.79
Details
Mouse Rabbit Un-conjugated IHC, WB Western blot analysis of extracts of various cell lines, using STAR antibody. 100 μL Log in to see 9 Days
$302.50
Details
Human Rabbit Un-conjugated IHC (p), WB   100 μL Log in to see 8 to 10 Days
$507.83
Details
Human Mouse Un-conjugated ELISA, WB Western Blot analysis of STAR expression in transfected 293T cell line by STAR monoclonal antibody (M01A), clone 5F9.Lane 1: STAR transfected lysate(31.9 KDa).Lane 2: Non-transfected lysate. Western Blot detection against Immunogen (36.63 KDa) . 200 μL Log in to see 9 Days
$430.00
Details

STAR Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine) ,


Rat (Rattus) ,


Human , ,
,
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Top referenced anti-STAR Antibodies

  1. Human Polyclonal STAR Primary Antibody for EIA, WB - ABIN954970 : Mizutani, Yazawa, Ju, Imamichi, Uesaka, Inaoka, Matsuura, Kamiki, Oki, Umezawa, Miyamoto: Identification of a novel distal control region upstream of the human steroidogenic acute regulatory protein (StAR) gene that participates in SF-1-dependent chromatin architecture. in The Journal of biological chemistry 2010 (PubMed)
    Show all 2 references for ABIN954970

  2. Human Monoclonal STAR Primary Antibody for RNAi, ELISA - ABIN563022 : Sedelaar, Isaacs: Tissue culture media supplemented with 10% fetal calf serum contains a castrate level of testosterone. in The Prostate 2009 (PubMed)

More Antibodies against STAR Interaction Partners

Mouse (Murine) Steroidogenic Acute Regulatory Protein (STAR) interaction partners

  1. cAMP, SIK (show SIK1 Antibodies) and CRTC mediate StAR expression through activation of individual StAR gene loci.

  2. Bisphenol A induces oxidative stress by altering the expression of iNOS (show NOS2 Antibodies), which consequently leads to the down regulation of StAR expression in the testis of male mouse

  3. Results show that HIF1alpha (show HIF1A Antibodies) appears to be a positive regulator of basal and stimulated STAR-expression, which under partial hypoxia is capable of increasing the steroidogenic capacity of granulosa cells.

  4. The result showed significant correlation between changes in GLUT 8 (show SLC2A8 Antibodies) and glucose levels with changes in StAR level in the testis and circulating testosterone level in the mice from birth to senescence

  5. Deletion of the START domain from Arabidopsis Glabra2, a representative HD-Zip transcription factor, results in a complete loss-of-function phenotype. The mammalian START domain from StAR can functionally replace the HD-Zip-derived START domain.

  6. These discoveries highlight the importance of mitochondrial fusion and ERK (show EPHB2 Antibodies) phosphorylation in cholesterol transport by means of directing StAR to the outer mitochondrial membrane.

  7. Data indicate that macrophages exhibited a strong time-dependent induction of mitochondrial StarD1 and plasma membrane ABCA1 (show ABCA1 Antibodies), which exports cholesterol.

  8. Data suggest that the regulation of StAR by transcription factors including SF-1 (show SF1 Antibodies), GATA-4 (show GATA4 Antibodies) and C/EBP-beta (show CEBPB Antibodies) maybe critical mechanism involved in low-dose MBP (show MBP Antibodies)-stimulated steroidogenesis.

  9. Sodium fluoride inhibited expression of StAR and P450scc (show CYP11A1 Antibodies) in mouse Leydig tumor cells, which inhibited progesterone secretion.

  10. HSL (show LIPE Antibodies) acts to drive cAMP/PKA-mediated regulation of StAR expression and steroidogenesis in mouse Leydig cells.

Human Steroidogenic Acute Regulatory Protein (STAR) interaction partners

  1. activins A, B and AB down-regulate StAR expression and decrease progesterone production in human granulosa cells, likely via an ALK4 (show ACVR1B Antibodies)-mediated SMAD2 (show SMAD2 Antibodies)/SMAD4 (show SMAD4 Antibodies)-dependent pathway.

  2. Mutagenesis confirmed that Arg(312) and Arg(313) are crucial for this mode of regulation, and novel interactions with the START domain

  3. StAR proteolysis is executed by at least 2 mitochondrial proteases, the matrix LON (show LONP1 Antibodies) protease and the inner membrane complexes of the metalloproteases AFG3L2 (show AFG3L2 Antibodies) and AFG3L2 (show AFG3L2 Antibodies):SPG7/paraplegin (show SPG7 Antibodies).

  4. BMP15 (show BMP15 Antibodies) down-regulates StAR expression and decreases progesterone production in human granulosa cells, likely via ALK3 (show BMPR1A Antibodies)-mediated SMAD1 (show GARS Antibodies)/5/8 signaling.

  5. The novel mutation p.Trp147Arg of the steroidogenic acute regulatory protein causes classic lipoid congenital adrenal hyperplasia with adrenal insufficiency and 46,XY disorder of sex development.

  6. Expression of StAR and P45011beta (cytochrome P450 family 11 subfamily B polypeptide 1 (show CYP11B1 Antibodies)) is down-regulated in adrenocortical cells and neurons under oxidative stress by ALADIN (show AAAS Antibodies) (triple A syndrome protein, human) knockdown.

  7. deficiencies in the steroidogenic acute regulatory protein and the cholesterol side chain cleavage (show CYP11A1 Antibodies) enzyme cause neonatal adrenal failure

  8. Mutant FOXL2 (show FOXL2 Antibodies) in granulosa cell tumors is able to differentially regulate the expression of many genes, including two well known FOXL2 (show FOXL2 Antibodies) targets, StAR and CYP19A (show CYP19A1 Antibodies).

  9. Mutations in the CYP11A1 (show CYP11A1 Antibodies) gene encoding cholesterol side-chain cleavage (show CYP11A1 Antibodies) enzyme cause disordered pregnenolone synthesis, and STAR mutations do not necessarily results in typical congenital lipoid adrenal hyperplasia.

  10. The status of ARO (show CYP19A1 Antibodies) and StAR contribute to estrogen synthesis in situ, especially for the regulation of elastic fiber formation, and to testosterone synthesis, which may be associated with hair growth, respectively.

Cow (Bovine) Steroidogenic Acute Regulatory Protein (STAR) interaction partners

  1. Data indicate that Ser738/742-to-glutamate (show GRIN2A Antibodies) protein kinase D (show PRKD1 Antibodies) mutant increased AngII-induced CREB (show CREB1 Antibodies) protein and activating transcription factor 2 (show ATF2 Antibodies) phosphorylation, and phospho-CREB (show CREB1 Antibodies) binding to the steroidogenic acute regulatory protein promoter.

  2. Data suggest that Escherichia coli infections (here, administration of LPS (show IRF6 Antibodies)) provokes luteolysis in diestrus, non-lactating cows and down-regulation of expression of StAR in corpus luteum but has no effect on luteinization in the following cycle.

  3. The binding of SF-1 (show NR5A1 Antibodies) to the CYP17 (show CYP17A1 Antibodies) and StAR promoter regions increased in theca cells incubated with low levels of luteinizing hormone.

  4. Inhibition of the acetylation of histone H3 (show HIST3H3 Antibodies) associated with the StAR promoter region by BMP-4 (show BMP4 Antibodies) may be one of the inhibitory molecular mechanisms of progesterone synthesis in granulosa cells.

  5. c-Fos/c-Jun (show JUN Antibodies) complex binds to the proximal StAR promoter in glomerulosa cells, thus activating StAR gene expression and acute aldosterone biosynthesis.

Guinea Pig Steroidogenic Acute Regulatory Protein (STAR) interaction partners

  1. The results showed that MMP-2 (show MMP2 Antibodies), MMP-9 (show MMP9 Antibodies), and StAR were significantly expressed in the granulosa and thecal cells of the ovarian atretic follicles during proestrus, and were strongly expressed in the corpus luteum during metestrus.

Pig (Porcine) Steroidogenic Acute Regulatory Protein (STAR) interaction partners

  1. GATA-4 (show GATA4 Antibodies) and C/EBPbeta (show CEBPB Antibodies) are both required for FSH (show BRD2 Antibodies) +/- IGF-I (show IGF1 Antibodies) stimulation of the porcine steroidogenic acute regulatory protein gene promoter in homologous granulosa cell cultures.

  2. EGF (show EGF Antibodies) repression of FSH (show BRD2 Antibodies)-stimulated StAR transcription in porcine granulosa cells is accompanied by reductions in histone H3 (show HIST3H3 Antibodies) acetylation associated with the StAR gene promoter

  3. The altered ratio of GATA4 (show GATA4 Antibodies) to GATA6 (show GATA6 Antibodies) after ovulation may allow GATA6 (show GATA6 Antibodies) to enhance STAR mRNA accumulation.

  4. Under hypoxia reoxygenation or ischemia and reperfusion, StAR and CYP11A1 protein and gene expression was reduced without apparent relation to TSPO changes.

Rainbow Trout (Oncorhynchus mykiss) Steroidogenic Acute Regulatory Protein (STAR) interaction partners

  1. Data suggest enzymes in steroidogenic pathway are induced in interrenal cells during acute/chronic stress: mc2r (melanocortin 2 receptor (show MC2R Antibodies)); StAR (steroidogenic acute regulatory protein); 3beta-hydroxysteroid dehydrogenase; steroid 11beta hydroxylase.

Zebrafish Steroidogenic Acute Regulatory Protein (STAR) interaction partners

  1. Results suggest that gonadotropins play a key role in the regulation of StAR, 17beta-HSD3, and P450aromA in zebrafish.

STAR Antigen Profile

Protein Summary

The protein encoded by this gene plays a key role in the acute regulation of steroid hormone synthesis by enhancing the conversion of cholesterol into pregnenolone. This protein permits the cleavage of cholesterol into pregnenolone by mediating the transport of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane. Mutations in this gene are a cause of congenital lipoid adrenal hyperplasia (CLAH), also called lipoid CAH. A pseudogene of this gene is located on chromosome 13.

Gene names and symbols associated with STAR

  • steroidogenic acute regulatory protein (STAR) antibody
  • steroidogenic acute regulatory protein (star) antibody
  • steroidogenic acute regulator (LOC100219165) antibody
  • steroidogenic acute regulatory protein (Star) antibody
  • steroidogenic acute regulatory protein-like (LOC100353723) antibody
  • AV363654 antibody
  • D8Ertd419e antibody
  • LOC100219165 antibody
  • star antibody
  • StARD1 antibody

Protein level used designations for STAR

steroidogenic acute regulator , steroidogenic acute regulatory protein , mitochondrial steroidogenic acute regulatory protein , steroidogenic acute regulatory protein, mitochondrial , START domain-containing protein 1 , luteinizing hormone-induced protein , stARD1 , START domain containing 1 , StAR-related lipid transfer (START) domain containing 1 , cholesterol trafficker , mitochondrial steroid acute regulatory protein , steroid acute regulatory protein , lipid transporter

GENE ID SPECIES
746738 Pan troglodytes
751772 Taeniopygia guttata
100125473 Oryzias latipes
100219165 Taeniopygia guttata
100528320 Ictalurus punctatus
100616071 Felis catus
20845 Mus musculus
25557 Rattus norvegicus
6770 Homo sapiens
475588 Canis lupus familiaris
281507 Bos taurus
395421 Gallus gallus
100009707 Equus caballus
443122 Ovis aries
100732626 Cavia porcellus
396597 Sus scrofa
100381120 Xenopus laevis
100135806 Oncorhynchus mykiss
63999 Danio rerio
101844174 Mesocricetus auratus
100353723 Oryctolagus cuniculus
Selected quality suppliers for anti-STAR (STAR) Antibodies
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