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Sterol Carrier Protein 2 Proteins (SCP2)

SCP2 encodes two proteins (SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. Additionally we are shipping SCP2 Antibodies (122) and SCP2 Kits (13) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SCP2 52468 Q8BX07
SCP2 6342 P22307
SCP2 25541 P11915
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Top SCP2 Proteins at antibodies-online.com

Showing 10 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human GST tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast REACT_Wheat His tag   1 mg Log in to see 56 to 66 Days
$2,141.33
Details
Yeast REACT_Spinach His tag   1 mg Log in to see 56 to 66 Days
$2,146.83
Details
Yeast REACT_Maize/Corn His tag   1 mg Log in to see 56 to 66 Days
$2,154.17
Details
Yeast Amaranthus caudatus His tag   1 mg Log in to see 56 to 66 Days
$2,156.00
Details
Yeast REACT_Millet His tag   1 mg Log in to see 56 to 66 Days
$2,159.67
Details
Yeast REACT_Purple witchweed His tag   1 mg Log in to see 56 to 66 Days
$2,209.17
Details

SCP2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,
Rat (Rattus)

More Proteins for Sterol Carrier Protein 2 (SCP2) Interaction Partners

Mouse (Murine) Sterol Carrier Protein 2 (SCP2) interaction partners

  1. Sterol Carrier Protein-2, a Nonspecific Lipid-Transfer Protein, in Intracellular Cholesterol Trafficking in Testicular Leydig Cells

  2. L-FABP (show FABP1 Proteins) was more important in hepatic retention of bile acids, while SCP-2/SCP-x more broadly affected biliary bile acid and phospholipid levels.

  3. Loss of L-FABP (show FABP1 Proteins) and SCP-2 (show CRISP3 Proteins), or both induces hepatic lipid accumulation in female mice and mimics non-alcoholic fatty liver disease.

  4. CTDSP2 (show CTDSP2 Proteins) induces p21(Cip1/Waf1 (show CDKN1A Proteins)) through increasing the activity of Ras.

  5. SCP-2/SCP-x may function more in formation and biliary secretion of bile acid, with less impact on hepatic uptake or biliary secretion of HDL (show HSD11B1 Proteins)-cholesterol

  6. liver fatty acid-binding protein, the single most prevalent hepatic cytosolic protein that binds cholesterol, was upregulated twofold in SCP-2 (show CRISP3 Proteins) null hepatocytes

  7. SCP-2 expression plays a significant role in HDL-mediated cholesterol efflux by regulating the size of rapid vs. slow cholesterol efflux pools and/or eliciting concomitant upregulation of L-FABP in cultured primary hepatocytes.

  8. Effect of Scp2 (show CRISP3 Proteins) expression on the rate of sterol transfer from lysosomal membranes, and lysosomal membrane lipid distribution.

  9. Data show that expression of sterol carrier protein-2 (SCP-2) increased fatty acid uptake and targeted fatty acid to unique lipid pools, suggesting that SCP-2 (show CRISP3 Proteins) may effectively serve as universal fatty acid binding and trafficking protein.

  10. Results suggest a key regulatory role for sterol carrier protein-2 in hepatic lipid metabolism.

Human Sterol Carrier Protein 2 (SCP2) interaction partners

  1. We conclude that SCP-2 (show CTDSP2 Proteins) is a low affinity binding protein for arachidonylethanolamine that can facilitate its cellular uptake but does not contribute significantly to intracellular sequestration of AEA.

  2. The Peroxisomal targeting signal 1 in Scp2 (show CTDSP2 Proteins) is autonomous and is essential for binding to pex5 (show PEX5 Proteins).

  3. cellular SCP-2 (show CTDSP2 Proteins) not only binds and translocates cholesterol but also cholesterol hydroperoxides, thus expanding their redox toxicity and signaling ranges under oxidative stress conditions

  4. Statistical analysis indicated that six genes, NFATC2, SCP2, CACNA1C, TCRA, POLE, and FAM3D, were associated with narcolepsy.

  5. data for the first time showed that while the N-terminal membrane binding domain of SCP(2 (show CTDSP2 Proteins)) was itself inactive in mediating intermembrane sterol transfer, it nevertheless potentiated the ability of SCP(2 (show CTDSP2 Proteins)) to enhance sterol transfer

  6. SCP2 (show CTDSP2 Proteins) in the cellular defense against oxidative damage and found that a fluorescent fatty acid analog bound to SCP2 (show CTDSP2 Proteins) is protected against H2O2/Cu2+-induced oxidative damage

  7. Overexpression of human SCP-2 (show CTDSP2 Proteins) in murine fibroblasts significantly alters the sterol dynamics of caveolae/lipid rafts, but not nonlipid raft domains, to facilitate retention of cholesterol within the cell.

  8. By trafficking cholesterol hydroperoxides and phospholipid hydroperoxides in addition to parent lipids, SCP2 (show CTDSP2 Proteins) may exacerbate cell injury under oxidative stress conditions

  9. Long chain fatty acyl-coenzyme A (show SOAT2 Proteins) (CoA)s are confirmed to be high affinity ligands for SCP2 (show CTDSP2 Proteins), while long chain fatty acyl-carnitines are demonstrated for the first time not to interact with SCP2 (show CTDSP2 Proteins).

  10. the importance of the N-terminal presequence in regulating SCP-2 (show CTDSP2 Proteins) structure, cholesterol localization within the ligand binding site, membrane association, and, potentially, intracellular targeting

Cow (Bovine) Sterol Carrier Protein 2 (SCP2) interaction partners

  1. By trafficking cholesterol hydroperoxides and phospholipid hydroperoxides in addition to parent lipids, SCP2 may exacerbate cell injury under oxidative stress conditions. [sterol carrier protein 2, SCP2, nonspecific lipid transfer protein]

SCP2 Protein Profile

Protein Summary

This gene encodes two proteins (SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. The transcript initiated from the proximal promoter encodes the longer SCPx protein, and the transcript initiated from the distal promoter encodes the shorter SCP2 protein, with the 2 proteins sharing a common C-terminus. Evidence suggests that the SCPx protein is a peroxisome-associated thiolase that is involved in the oxidation of branched chain fatty acids, while the SCP2 protein is thought to be an intracellular lipid transfer protein. This gene is highly expressed in organs involved in lipid metabolism, and may play a role in Zellweger syndrome, in which cells are deficient in peroxisomes and have impaired bile acid synthesis. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms.

Gene names and symbols associated with SCP2

  • CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 (Ctdsp2)
  • phospholipid transfer protein homolog1 (plt1)
  • sterol carrier protein 2 (SCP2)
  • sterol carrier protein 2 (Scp2)
  • sterol carrier protein 2, liver (Scp2)
  • AA409774 protein
  • AA409893 protein
  • AI586070 protein
  • C76618 protein
  • C79031 protein
  • D10Ertd73e protein
  • NLTP protein
  • ns-LTP protein
  • NSL-TP protein
  • NSLIPTR protein
  • OS-4 protein
  • OS4 protein
  • PLTP protein
  • SCP-2 protein
  • SCP-CHI protein
  • SCP-X protein
  • SCP2 protein
  • SCPx protein

Protein level used designations for SCP2

carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 , nuclear LIM interactor-interacting factor 2 (NLI-interacting factor 2) (Protein OS-4) , small C-terminal domain phosphatase 2 , CL468_1 , CL468_1(249) , CL468_1_ov , LTP , allergen Zea m 14 , non-specific lipid-transfer protein , propanoyl-CoA C-acyltransferase , sterol carrier protein X , NSL-TP , SCP-2 , SCP-X , SCP-chi , Sterol carrier protein 2, liver , sterol carrier protein-2 , SCPX , sterol carrier protein 2, liver , nonspecific lipid transfer protein

GENE ID SPECIES
52468 Mus musculus
542231 Zea mays
6342 Homo sapiens
479564 Canis lupus familiaris
397439 Sus scrofa
508918 Bos taurus
25541 Rattus norvegicus
396550 Gallus gallus
100008683 Oryctolagus cuniculus
100728738 Cavia porcellus
101116445 Ovis aries
20280 Mus musculus
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