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SREBF2 encodes a ubiquitously expressed transcription factor that controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. Additionally we are shipping Sterol Regulatory Element Binding Transcription Factor 2 Antibodies (62) and Sterol Regulatory Element Binding Transcription Factor 2 Kits (6) and many more products for this protein.
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This study reveals SHP (show LAMC1 Proteins) as a global transcriptional partner of SREBP-2 in regulation of sterol biosynthetic gene networks and provides a potential mechanism for cholesterol-lowering action of FGF19 (show FGF19 Proteins).
activation of the sterol regulatory element binding protein-2 (SREBP2) was found to be downstream of ER stress, and this activation was affirmed to account for the intracellular accumulation of cholesterol using RNAi technique
ITCH modulates SIRT6 (show SIRT6 Proteins) and SREBP2 to influence lipid metabolism and atherosclerosis in ApoE (show APOE Proteins) null mice
SREBP2-induced miR-92a targets k (show MLXIP Proteins)ey molecules in endothelial homeostasis, including sirtuin 1, Kruppel-like factor 2, and Kruppel-like factor 4, leading to NOD-like receptor family pyrin domain-containing 3 inflammasome activation and endothelial nitric oxide synthase inhibition.
The cholesterol-lowering effects of FGF21 (show FGF21 Proteins) are abrogated by hepatic expression of sterol regulatory element-binding protein-2.
Data indicate that Leishmania exploits macrophage cholesterol-dependent sterol regulatory element binding factor 2 (SREBP2) circuit to facilitate its entry and survival within the host.
Demonstrate that the activation of FXR (show NR1H4 Proteins) uncouples the expression of nuclear SREBP-2 and miR (show MLXIP Proteins)-33, and the regulation of their respective target genes.
the cardiac sterol regulatory element-binding protein-2/3-hydroxy-3-methylglutaryl-coenzyme A reductase (show HMGCR Proteins) pathway being upregulated in MMP-2 (show MMP2 Proteins) deficiency.
activation of intestinal SREBP2 alone seems to be sufficient to increase plasma cholesterol
Hepatic insulin receptor (show INSR Proteins) knockout mice manifest decreased nuclear SREBP-2 protein, decreased cholesterologenic gene expression, and decreased cholesterol synthesis.
Data show that mutant p53 protein (show TP53 Proteins) activates the sterol regulatory element-binding proteins SREBP-1 (show SREBF1 Proteins) and SREBP-2-mediated signaling pathways in prostate cancer (PCa (show FLVCR1 Proteins)) cells.
The connections of EGFR (show EGFR Proteins) and ERBB4 (show ERBB4 Proteins) signaling with SREBP-2-regulated cholesterol metabolism are likely to be important in ERBB (show EGFR Proteins)-regulated developmental processes and may contribute to metabolic remodeling in ERBB (show EGFR Proteins)-driven cancers.
Akt1 (show AKT1 Proteins) and Akt2 (show AKT2 Proteins) activated both SREBP-1 (show SREBF1 Proteins) and SREBP-2, whereas Akt3 (show AKT3 Proteins) upregulated SREBP-1 (show SREBF1 Proteins) to enhance hepatitis C virus translation.
knockdown of endogenous SREBP2 in HepG2 cells lowered ACSL1 (show Acsl1 Proteins) mRNA and protein levels.
Data suggest that Hepacivirus (HCV) activates hepatocyte NLRP3 (show NLRP3 Proteins) inflammasomes, induces lipogenic enzymes/lipid droplet formation, and up-regulates transport of SREBF1 (show SREBF1 Proteins)/SREBF2/SCAP (show SH2D2A Proteins) from ER to Golgi where SREBPs undergo proteolytic activation by S1P (show MBTPS1 Proteins)/S2P (show MBTPS2 Proteins).
Data suggest lysophosphatidylcholine (LPC (show PCSK7 Proteins)) up-regulates SREBP-2 and cholesterol efflux in vascular endothelium; 25-hydroxycholesterol (25-HC) inhibits these effects of LPC (show PCSK7 Proteins); both LPC (show PCSK7 Proteins) and 25-HC up-regulate release of interleukin-6 (show IL6 Proteins) and interleukin-8 (show IL8 Proteins).
the results of the present study showed that luteolin modulates HMGCR (show HMGCR Proteins) transcription by decreasing the expression and nuclear translocation of SREBP-2.
performed a detailed promoter/enhancer analysis of ELOVL5 gene, and identified two new SREBP binding sites, one in the 10 kb upstream region and one in the exon 1
HCV core protein disturbs the cholesterol homeostasis in HepG2 cells via the SREBP2 pathway; miR-185-5p is involved in the regulation of SREBP2 by the core protein.
the 5-aminoimidazole-4-carboxyamide ribonucleoside (AICAR (show ATIC Proteins))-induced activation of AMPK (show PRKAA1 Proteins) directly inhibited the expression of SREBP-2 and HMGCR (show HMGCR Proteins) and HMGCS (show HMGCS1 Proteins), and suppressed the TSH-stimulated up-regulation of SREBP-2 in HepG2 cells.
dysregulation of SIRT1 (show SIRT1 Proteins)-AMPK (show PRKAA1 Proteins)-SREBP and stimulation of NLRP3 (show NLRP3 Proteins) inflammasome may contribute to vascular lipid deposition and inflammation in atherosclerosis
KLF13 (show KLF13 Proteins) and SREBP-Sp1 (show SP1 Proteins) activation interact to regulate low density lipoprotein receptor (show LDLR Proteins) promoter function
This gene encodes a ubiquitously expressed transcription factor that controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain.
sterol regulatory element binding transcription factor 2
, sterol regulatory element-binding protein 2-like
, sterol regulatory element binding protein 2
, sterol regulatory element-binding protein 2
, sterol regulatory element-binding transcription factor 2
, class D basic helix-loop-helix protein 2
, sterol regulatory element binding factor 2