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Stimulated By Retinoic Acid 6 Proteins (STRA6)

The protein encoded by STRA6 is a membrane protein involved in the metabolism of retinol. Additionally we are shipping STRA6 Antibodies (77) and STRA6 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat STRA6 STRA6 363071 Q4QR83
STRA6 64220 Q9BX79
STRA6 20897 O70491
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Top STRA6 Proteins at antibodies-online.com

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details

STRA6 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
,

More Proteins for Stimulated By Retinoic Acid 6 (STRA6) Interaction Partners

Human Stimulated By Retinoic Acid 6 (STRA6) interaction partners

  1. A novel mutation in two Hmong families broadens the range of STRA6-related malformations to include contractures and camptodactyly.

  2. These data establish that holo-RBP (show RBP4 Proteins) and its receptor STRA6 are potent oncogenes and suggest that the pathway is a novel target for therapy of some human cancers.

  3. Evidence for the existence of a transmembrane pore, analogous to the pore of ion channels, in STRA6.

  4. STRA6 has a role for regulating retinoid homeostasis and in helping to program signaling that drives proliferation and differentiation of human skin cells

  5. Stra6, a retinoic acid-responsive (show GPRC5A Proteins) gene, participates in p53 (show TP53 Proteins)-induced apoptosis after DNA damage.

  6. Analysis of FRAS1 and STRA6 mutations in the same family with eye anomalies.

  7. Findings suggest that heterozygosity for the STRA6 gene mutation may be associated with ocular abnormalities.

  8. TTR (show TTR Proteins) blocks the ability of holo-retinol-binding protein to associate with STRA6 and thereby effectively suppresses both STRA6-mediated retinol uptake and STRA6-initiated cell signaling.

  9. STRA6 orchestrates a multicomponent machinery that couples vitamin A homeostasis and metabolism to activation of a signaling cascade and that, in turn, STRA6 signaling regulates the cellular uptake of the vitamin.

  10. STRA6 mutations can cause isolated eye malformations in addition to the congenital anomalies observed in MWS.

Mouse (Murine) Stimulated By Retinoic Acid 6 (STRA6) interaction partners

  1. Studies indicate that STRA6 is indeed a bona fide vitamin A transporter and provide novel insights into the regulatory mechanism that governs vitamin A homeostasis in peripheral tissues.

  2. Total vitamin A levels are dramatically lower in the eyes of STRA6 KO mice as compared to those of WT mice, but the levels in other organs were not significantly affected after STRA6 deletion under vitamin A sufficient conditions.

  3. STRA6 reduction in adipocytes in adipose-Stra6(-/-) mice.

  4. Rbp4 (show RBP4 Proteins) and its membrane receptor STRA6 control adipogenesis by regulating cellular retinoid homeostasis and RARalpha (show RARA Proteins) activity.

  5. STRA6 in tissues other than the eye appears to be the coupling of circulating holo-RBP (show RBP4 Proteins) levels to cell signaling, in turn regulating key processes such as insulin (show INS Proteins) response.

  6. Stra6, a retinoic acid-responsive gene, participates in p53 (show TP53 Proteins)-induced apoptosis after DNA damage.

  7. TTR (show TTR Proteins) blocks the ability of holo-retinol-binding protein to associate with STRA6 and thereby effectively suppresses both STRA6-mediated retinol uptake and STRA6-initiated cell signaling.

  8. LRAT (show LRAT Proteins) acts together with Cyp26A1 (show CYP26A1 Proteins), one of the enzymes that catalyze the degradation of retinoic acid, and possibly with STRA6, the recently identified cell surface receptor for retinol-RBP (show RBP4 Proteins)

Cow (Bovine) Stimulated By Retinoic Acid 6 (STRA6) interaction partners

  1. STRA6 was identified in retinal pigment epithelium cells as a specific membrane receptor for retinol binding protein (RBP (show RBP4 Proteins)); STRA6 binds to RBP (show RBP4 Proteins) with high affinity and has robust vitamin A uptake activity from the vitamin A-RBP (show RBP4 Proteins) complex

  2. study identifies an essential functional domain in STRA6

STRA6 Protein Profile

Protein Summary

The protein encoded by this gene is a membrane protein involved in the metabolism of retinol. The encoded protein acts as a receptor for retinol/retinol binding protein complexes. This protein removes the retinol from the complex and transports it across the cell membrane. Defects in this gene are a cause of syndromic microphthalmia type 9 (MCOPS9). Several transcript variants encoding a few different isoforms have been found for this gene.

Gene names and symbols associated with STRA6

  • stimulated by retinoic acid 6 (Stra6)
  • stimulated by retinoic acid 6 (STRA6)
  • stimulated by retinoic acid gene 6 (Stra6)
  • stimulated by retinoic acid gene 6 homolog (mouse) (STRA6)
  • AI891933 protein
  • MCOPCB8 protein
  • MCOPS9 protein
  • RGD1307551 protein

Protein level used designations for STRA6

stimulated by retinoic acid gene 6 homolog , stimulated by retinoic acid gene 6 protein homolog , stimulated by retinoic acid 6 homolog , retinoic acid-responsive protein , stimulated by retinoic acid gene 6 protein

GENE ID SPECIES
363071 Rattus norvegicus
64220 Homo sapiens
20897 Mus musculus
515911 Bos taurus
100174192 Pongo abelii
611518 Canis lupus familiaris
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