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Meiosis-inducer required for the transition into meiosis for both female and male germ cells. Additionally we are shipping and and many more products for this protein.
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Human Polyclonal STRA8 Primary Antibody for IF, IHC (p) - ABIN655383
Le Bouffant, Guerquin, Duquenne, Frydman, Coffigny, Rouiller-Fabre, Frydman, Habert, Livera: Meiosis initiation in the human ovary requires intrinsic retinoic acid synthesis. in Human reproduction (Oxford, England) 2010
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The genetic variant rs10269148 of STRA8 gene shows higher risk of spermatogenic impairment in the groups of abnormospermia than the controls
Functional characterization of an homologous mouse gene.
Expression restricted to testis (STRA8)
SMAD4 (show SMAD4 Antibodies) and STRA8 are essential factors that regulate the female fate of germ cells.
SOHLH1 (show SOHLH1 Antibodies) and SOHLH2 (show SOHLH2 Antibodies) were able to directly and cooperatively repress STRA8 expression in cell lines in vitro through binding to its promoter.
Our findings strengthen the importance of RA and Dazl (show DAZL Antibodies) in the meiotic transition, provide important details about the Stra8 pathway, and open avenues to investigate early meiosis through analysis of Rec8 (show REC8 Antibodies) induction and function
periodic RA-STRA8 signaling intersects with periodic germ-cell competencies to regulate two distinct, cell-type-specific responses: spermatogonial differentiation and meiotic initiation
Our findings suggest that the mTOR (show FRAP1 Antibodies) signaling pathway may have role in the proliferation and stimulation of meiotic initiation of spermatogonial stem cells
CYP26B1 (show CYP26B1 Antibodies) suppresses two distinct genetic programs induced by retinoic acid: a Stra8-dependent meiotic pathway, and a Stra8-independent mitotic pathway.
cultured XX and XY germ cells at 11.5 and 12.5 days postcoitus (dpc) with an RA receptor inhibitor. Expression of Stra8, a meiosis initiation gene, was suppressed in all groups
Stra8-deficient mice had an 88% decrease in teratoma (show DND1 Antibodies) incidence, providing direct evidence that premature initiation of the meiotic program contributes to tumorigenesis.
DMRT1 (show DMRT1 Antibodies) controls Stra8 sex-specifically, activating it in the fetal ovary and repressing it in the adult testis.
Stra8 and Dazl (show DAZL Antibodies) are highly expressed in premeiotic germ cells that do not undergo further differentiation in aged mouse ovaries.
Meiosis-inducer required for the transition into meiosis for both female and male germ cells. In female germ cells, required for premeiotic DNA replication and subsequent events in meiotic prophase.
stimulated by retinoic acid 8 homolog
, stimulated by retinoic acid gene 8 homolog
, stimulated by retinoic acid gene 8 protein homolog
, stimulated by retinoic acid gene 8
, stimulated by retinoic acid gene 8 protein