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STON2 encodes a protein which is a membrane protein involved in regulating endocytotic complexes. Additionally we are shipping Stonin 2 Antibodies (3) and and many more products for this protein.
The present study demonstrated that the functional variant of the STON2 gene could alter cortical surface area on the right inferior temporal and contribute to the pathogenesis of schizophrenia.
STON2 may be a susceptibility gene for Chinese Han patients with schizophrenia.
The ability of stonin 2 to facilitate endocytosis of synaptotagmin is dependent on its association with AP-2 (show GTF3A ELISA Kits), an intact mu-homology domain, and functional AP-2 (show GTF3A ELISA Kits) heterotetramers.
Our data identify the molecular determinants for recognition of synaptotagmin by stonin 2 or its Caenorhabditis elegans orthologue UNC-41B.
Loss of Stn2 leads to selective missorting of synaptotagmin 1 (show SYT1 ELISA Kits) to the neuronal surface, an elevated synaptic vesicle (SV) pool size, and accelerated SV protein endocytosis.
This gene encodes a protein which is a membrane protein involved in regulating endocytotic complexes. The protein product is described as one of the clathrin-associated sorting proteins, adaptor molecules which ensure specific proteins are internalized. The encoded protein has also been shown to participate in synaptic vesicle recycling through interaction with synaptotagmin 1 required for neurotransmission. Multiple transcript variants encoding different isoforms have been found for this gene.
, homolog of stoned B
, stoned B homolog 2
, stoned B