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STIM1 encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). Additionally we are shipping STIM1 Antibodies (149) and STIM1 Kits (2) and many more products for this protein.
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Human STIM1 Protein expressed in Human Cells - ABIN2004286
Sabbioni, Barbanti-Brodano, Croce, Negrini: GOK: a gene at 11p15 involved in rhabdomyosarcoma and rhabdoid tumor development. in Cancer research 1997
Show all 5 references for ABIN2004286
Human STIM1 Protein expressed in Escherichia coli (E. coli) - ABIN666653
Várnai, Tóth, Tóth, Hunyady, Balla: Visualization and manipulation of plasma membrane-endoplasmic reticulum contact sites indicates the presence of additional molecular components within the STIM1-Orai1 Complex. in The Journal of biological chemistry 2007
Show all 2 references for ABIN666653
Human STIM1 Protein expressed in Wheat germ - ABIN1321631
Hawkins, Irrinki, Mallilankaraman, Lien, Wang, Bhanumathy, Subbiah, Ritchie, Soboloff, Baba, Kurosaki, Joseph, Gill, Madesh: S-glutathionylation activates STIM1 and alters mitochondrial homeostasis. in The Journal of cell biology 2010
Downregulation of STIM1 levels in oocytes by siRNA completely inhibited the repetitive Ca(2 (show CA2 Proteins)+) signal triggered by the fertilizing sperm.
findings suggest that in oocytes, STIM1 serves as a sensor of Ca(2 (show CA2 Proteins)+) store content that after store depletion moves to the plasma membrane to stimulate store-operated Ca(2 (show CA2 Proteins)+) entry
STIM1 plays role in PAR1 (show F2R Proteins)-mediated Ca2 (show CA2 Proteins)+ influx and Ca2 (show CA2 Proteins)+-dependent NO production in endothelial cells; DNA sequence alignment of porcine and human STIM1
STIM1/TRPC1 (show TRPC1 Proteins)-dependent store-operated Ca2 (show CA2 Proteins)+ entry plays an essential role in generating spatiotemporal Ca2 (show CA2 Proteins)+ signals that mediate guidance responses of nerve growth cones.
STIM1 and Orai1 are essential components of the signal transduction cascade that regulates sex pheromone production.
Coupling of the endoplasmic reticulum (ER) Ca(2 (show CA2 Proteins)+)sensor, stromal interaction molecule 1 (STIM1), to the Ca(2 (show CA2 Proteins)+)-selective channel, Orai1, is regulated by these elements and depends on membrane organization, both at the plasma membrane and at the ER
STIM11-469 and Orai1 W76A mutants do not reduce channel open probability.
T Cell Receptor-induced Nuclear Factor kappaB (NF-kappaB) Signaling and Transcriptional Activation Are Regulated by STIM1- and Orai1-mediated Calcium Entry.
study reports recessive STIM1 mutations in patients presenting with amelogenesis imperfecta and hypohidrosis without overt clinical immunodeficiency or myopathy
Data suggest that stromal interaction molecule 1 (STIM1) may be developed as a potential therapeutic target of cancer treatment.
We demonstrate that the Orai1/STIM1 channel is regulated by changes of both intracellular and extracellular pH.
Sigma1 receptors attenuates STIM1 coupling to Orai1 and thereby inhibits SOCE.
Studies suggest that STIM1 protein and calcium channel Orai1-mediated Ca2 (show CA2 Proteins)+ signaling are the potential target for cancer therapy.
Studies indicate that Ca(2 (show CA2 Proteins)+) sensor STIM1 and calcium channel Orai1 upregulation in cancer cells results in Ca2 (show CA2 Proteins) + homeostasis remodeling and cell proliferation.
STIM1 also promoted cell migration and the epithelial-to-mesenchymal transition by activating TGF-beta (show TGFB1 Proteins), Snail (show SNAI1 Proteins) and Wnt (show WNT2 Proteins)/beta-Catenin (show CTNNB1 Proteins) pathways.
STIM1 and STIM2 (show Stim2 Proteins) are expressed in bovine aortic endothelial cells and they both interact with IP3R-1 (show ITPR1 Proteins).
We conclude that STIM1 has an unexpected function in the heart where it alters communication between the sarcolemma and sarcoplasmic reticulum resulting in greater Ca(2 (show CA2 Proteins)+) flux and a leaky SR compartment.
Stim1 silencing prevented mTOR complex 2 phosphorylation of Akt(S473) via a direct interaction between STIM1 and Rictor. This represses GSK-3beta activity and prevents/reverses cardiac hypertrophy.
role of STIM1, Orai1 and TRPCs, and thus SOCE, in thrombus formation, suggests that therapies directed against SOCE and targeting these molecules during cardiovascular and cerebrovascular events could improve traditional anti-thrombotic treatments
Quantitative Proteomics Reveals the Essential Roles of Stromal Interaction Molecule 1 (STIM1) in the Testicular Cord Formation in Mouse Testis
Results show the cytoplasmic domain of STIM1 as a target for calpains which cleave STIM1 to control its cellular abundance. Furthermore, STIM1's susceptibility to calpain cleavage leads to enhanced STIM1 degradation during the progression of apoptosis.
Orai1 (show TMEM132A Proteins) and STIM1 have roles in inhibiting matrix protein expression
STIM1 plays opposing roles in vascular smooth muscle vs. endothelial cells in the regulation of vascular reactivity.
STIM1 is a multifunctional regulator of Ca(2 (show CA2 Proteins)+) dynamics in SANCs that links SR Ca(2 (show CA2 Proteins)+) store content with electrical events occurring in the plasma membrane, thereby contributing to automaticity of the SAN
STIM1L does not mediate rapid store-operated Ca(2+) entry but can trap and gate Orai1 channels efficiently without remodeling cortical ER cisternae.
STIM1 is a key regulator of mGluR1 (show GRM1 Proteins)-dependent Ca(2 (show CA2 Proteins)+) signaling.
This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene.
stromal interaction molecule 1
, stromal interaction molecule 1b