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Stromal Interaction Molecule 1 Proteins (STIM1)

STIM1 encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). Additionally we are shipping STIM1 Antibodies (150) and STIM1 Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
STIM1 6786 Q13586
STIM1 20866 P70302
STIM1 361618 P84903
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Top STIM1 Proteins at antibodies-online.com

Showing 10 out of 19 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human His tag 100 μg Log in to see 16 Days
$272.80
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details
HOST_Escherichia coli (E. coli) Human CaM 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,451.17
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,458.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$364.64
Details

STIM1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, , , ,
Mouse (Murine) ,
,
Rat (Rattus)

Top referenced STIM1 Proteins

  1. Human STIM1 Protein expressed in Human Cells - ABIN2004286 : Sabbioni, Barbanti-Brodano, Croce, Negrini: GOK: a gene at 11p15 involved in rhabdomyosarcoma and rhabdoid tumor development. in Cancer research 1997 (PubMed)
    Show all 5 references for ABIN2004286

  2. Human STIM1 Protein expressed in Escherichia coli (E. coli) - ABIN666653 : Várnai, Tóth, Tóth, Hunyady, Balla: Visualization and manipulation of plasma membrane-endoplasmic reticulum contact sites indicates the presence of additional molecular components within the STIM1-Orai1 Complex. in The Journal of biological chemistry 2007 (PubMed)
    Show all 2 references for ABIN666653

  3. Human STIM1 Protein expressed in Wheat germ - ABIN1321631 : Hawkins, Irrinki, Mallilankaraman, Lien, Wang, Bhanumathy, Subbiah, Ritchie, Soboloff, Baba, Kurosaki, Joseph, Gill, Madesh: S-glutathionylation activates STIM1 and alters mitochondrial homeostasis. in The Journal of cell biology 2010 (PubMed)

More Proteins for Stromal Interaction Molecule 1 (STIM1) Interaction Partners

Pig (Porcine) Stromal Interaction Molecule 1 (STIM1) interaction partners

  1. Downregulation of STIM1 levels in oocytes by siRNA completely inhibited the repetitive Ca(2 (show CA2 Proteins)+) signal triggered by the fertilizing sperm.

  2. findings suggest that in oocytes, STIM1 serves as a sensor of Ca(2 (show CA2 Proteins)+) store content that after store depletion moves to the plasma membrane to stimulate store-operated Ca(2 (show CA2 Proteins)+) entry

  3. STIM1 plays role in PAR1 (show F2R Proteins)-mediated Ca2 (show CA2 Proteins)+ influx and Ca2 (show CA2 Proteins)+-dependent NO production in endothelial cells; DNA sequence alignment of porcine and human STIM1

Xenopus laevis Stromal Interaction Molecule 1 (STIM1) interaction partners

  1. STIM1/TRPC1 (show TRPC1 Proteins)-dependent store-operated Ca2 (show CA2 Proteins)+ entry plays an essential role in generating spatiotemporal Ca2 (show CA2 Proteins)+ signals that mediate guidance responses of nerve growth cones.

Silk Worm Stromal Interaction Molecule 1 (STIM1) interaction partners

  1. STIM1 and Orai1 are essential components of the signal transduction cascade that regulates sex pheromone production.

Human Stromal Interaction Molecule 1 (STIM1) interaction partners

  1. SARAF (show TMEM66 Proteins) overexpression attenuated store operated Ca2 (show CA2 Proteins)+ entry and the STIM1-Orai1 interaction in cells endogenously expressing STIM1 and Orai1 while RNAi-mediated SARAF (show TMEM66 Proteins) silencing induced opposite effects.

  2. Calsequestrin-1 (show CASQ1 Proteins) monomers suppress Store-Operated Ca2 (show CA2 Proteins)+ Entry by interacting with STIM1 and attenuating STIM1 aggregation via its C-terminal amino acid 362-396.

  3. the STIM1-Orai1 system has a role in intra-cellular calcium elevation induced by ATP in cultured human keratinocytes

  4. Coupling of the endoplasmic reticulum (ER) Ca(2 (show CA2 Proteins)+)sensor, stromal interaction molecule 1 (STIM1), to the Ca(2 (show CA2 Proteins)+)-selective channel, Orai1, is regulated by these elements and depends on membrane organization, both at the plasma membrane and at the ER

  5. STIM11-469 and Orai1 W76A mutants do not reduce channel open probability.

  6. T Cell Receptor-induced Nuclear Factor kappaB (NF-kappaB) Signaling and Transcriptional Activation Are Regulated by STIM1- and Orai1-mediated Calcium Entry.

  7. study reports recessive STIM1 mutations in patients presenting with amelogenesis imperfecta and hypohidrosis without overt clinical immunodeficiency or myopathy

  8. Data suggest that stromal interaction molecule 1 (STIM1) may be developed as a potential therapeutic target of cancer treatment.

  9. We demonstrate that the Orai1/STIM1 channel is regulated by changes of both intracellular and extracellular pH.

  10. Sigma1 receptors attenuates STIM1 coupling to Orai1 and thereby inhibits SOCE.

Cow (Bovine) Stromal Interaction Molecule 1 (STIM1) interaction partners

  1. STIM1 and STIM2 (show Stim2 Proteins) are expressed in bovine aortic endothelial cells and they both interact with IP3R-1 (show ITPR1 Proteins).

Mouse (Murine) Stromal Interaction Molecule 1 (STIM1) interaction partners

  1. Data show that the STIM1 Ksp (Eg5 (show KIF11 Proteins))-cre knockout mice produced more urine compared to control.

  2. We conclude that STIM1 has an unexpected function in the heart where it alters communication between the sarcolemma and sarcoplasmic reticulum resulting in greater Ca(2 (show CA2 Proteins)+) flux and a leaky SR compartment.

  3. Stim1 silencing prevented mTOR complex 2 phosphorylation of Akt(S473) via a direct interaction between STIM1 and Rictor. This represses GSK-3beta activity and prevents/reverses cardiac hypertrophy.

  4. role of STIM1, Orai1 and TRPCs, and thus SOCE, in thrombus formation, suggests that therapies directed against SOCE and targeting these molecules during cardiovascular and cerebrovascular events could improve traditional anti-thrombotic treatments

  5. Quantitative Proteomics Reveals the Essential Roles of Stromal Interaction Molecule 1 (STIM1) in the Testicular Cord Formation in Mouse Testis

  6. Results show the cytoplasmic domain of STIM1 as a target for calpains which cleave STIM1 to control its cellular abundance. Furthermore, STIM1's susceptibility to calpain cleavage leads to enhanced STIM1 degradation during the progression of apoptosis.

  7. Orai1 (show TMEM132A Proteins) and STIM1 have roles in inhibiting matrix protein expression

  8. STIM1 plays opposing roles in vascular smooth muscle vs. endothelial cells in the regulation of vascular reactivity.

  9. STIM1 is a multifunctional regulator of Ca(2 (show CA2 Proteins)+) dynamics in SANCs that links SR Ca(2 (show CA2 Proteins)+) store content with electrical events occurring in the plasma membrane, thereby contributing to automaticity of the SAN

  10. STIM1L does not mediate rapid store-operated Ca(2+) entry but can trap and gate Orai1 channels efficiently without remodeling cortical ER cisternae.

STIM1 Protein Profile

Protein Summary

This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene.

Gene names and symbols associated with STIM1

  • stromal interaction molecule 1 (STIM1)
  • stromal interaction molecule 1 (stim1)
  • stromal interaction molecule 1a (stim1a)
  • stromal interaction molecule 1b (stim1b)
  • stromal interaction molecule 1 (Stim1)
  • stromal interaction molecule 1 (LOC100345564)
  • D11S4896E protein
  • GOK protein
  • MGC76045 protein
  • MGC154748 protein
  • si:ch211-112l17.2 protein
  • si:dkey-24p1.5 protein
  • SIM protein
  • Stim1 protein
  • TAM protein

Protein level used designations for STIM1

stromal interaction molecule 1 , stromal interaction molecule 1b

GENE ID SPECIES
419082 Gallus gallus
100171399 Sus scrofa
100053079 Equus caballus
403095 Xenopus (Silurana) tropicalis
450973 Pan troglodytes
556360 Danio rerio
779419 Xenopus laevis
100005700 Danio rerio
100188967 Bombyx mori
100345564 Oryctolagus cuniculus
100380565 Salmo salar
6786 Homo sapiens
608643 Canis lupus familiaris
534816 Bos taurus
20866 Mus musculus
361618 Rattus norvegicus
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