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Stromal Interaction Molecule 2 Proteins (Stim2)

Stim2 is a member of the stromal interaction molecule (STIM) family and likely arose, along with related family member STIM1, from a common ancestral gene. Additionally we are shipping Stim2 Antibodies (68) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Stim2 57620 Q9P246
Stim2 116873 P83093
Stim2 117087  
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Top Stim2 Proteins at antibodies-online.com

Showing 6 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

Stim2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine) ,
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Rat (Rattus)

More Proteins for Stromal Interaction Molecule 2 (Stim2) Interaction Partners

Human Stromal Interaction Molecule 2 (Stim2) interaction partners

  1. While STIM1 is a full Orai1-agonist, leucine-replacement of this crucial residue in STIM2 endows it with partial agonist properties, which may be critical for limiting Orai1 activation stemming from its enhanced sensitivity to store-depletion

  2. STIM2.1 cannot activate Orai1 due to splicing in residues within the channel-activating domain (CAD). STIM2.1 confers a calcium dependent dominant-negative function on both STIM1 and STIM2 (STIM2.2). Affinity of the STIM2.1 calmodulin binding site within the CAD domain is increased compared to STIM2.2.

  3. STIM2 enhances receptor-stimulated Ca(2 (show CA2 Proteins)) signaling by promoting recruitment of STIM1 (show STIM1 Proteins) to the endoplasmic reticulum-plasma membrane junctions.

  4. STIM2beta does not by itself strongly bind Orai1, it is recruited to Orai1 channels by forming heterodimers with other STIM isoforms.

  5. Imin channels are regulated by STIM2, TRPC3 (show TRPC3 Proteins)-containing INS (show INS Proteins) channels are induced by STIM1 (show STIM1 Proteins), and TRPC1 (show TRPC1 Proteins)-composed Imax channels are activated by both STIM1 (show STIM1 Proteins) and STIM2.

  6. The higher amplitude of store-operated Ca2 (show CA2 Proteins)+ entry was associated to the over-expression for Stim2, Orai2 (show ORAI2 Proteins)-3, and TRPC1 (show TRPC1 Proteins) while Stim2 levels remained constant and Stim1 (show STIM1 Proteins), Orai1, Orai3, TRPC1 (show TRPC1 Proteins) and TRPC4 (show TRPC4 Proteins) proteins were over-expressed in primary myelofibrosis.

  7. the reciprocal shift in transient receptor potential channel 1 (TRPC1 (show TRPC1 Proteins)) and stromal interaction molecule 2 (STIM2) contributes to Ca2 (show CA2 Proteins)+ remodeling and cancer hallmarks in colorectal carcinoma cells

  8. STIM2 is highly expressed and controls store-operated Ca(2 (show CA2 Proteins)+) entry in human melanoma. The invasive and migratory potential of melanoma cells was reduced upon silencing of STIM2.

  9. Binding of the lysine rich domains of STIM1 (show STIM1 Proteins) and STIM2 to phosphatidylinositol 4,5 biphosphate rich liposomes depends on their oligomerization.

  10. STIM2 is involved in spatial l (show STIM1 Proteins)earning and plays an important rol (show CA2 Proteins)e in ischemic-induced neuronal cell death du (show CA2 Proteins)ring brain hypoxia. The absence of STIM2 reduces life expectancy in mice by sudden death.

Mouse (Murine) Stromal Interaction Molecule 2 (Stim2) interaction partners

  1. Expression of STIM2 protein rescued CaMKII (show CAMK2G Proteins) activity and protected mushroom spines from Abeta42 oligomer toxicity in vitro and in vivo.

  2. SOCE blockers or ablation of STIM1, STIM2, or Orai1 severely impaired nucleotide-induced migration and phagocytosis in microglia.

  3. The data from this study indicate that upregulation of STIM2 and Orai2 (show ORAI2 Proteins) is involved in the phenotypic transition of pulmonary arterial smooth muscle cells from a contractile state to a proliferative state.

  4. STIM1 (show STIM1 Proteins), STIM2, and CRAC channel function play distinct but synergistic roles in CD4 (show CD4 Proteins)+ and CD8 (show CD8A Proteins)+ T cells during antiviral immunity

  5. STIM2 deficiency significantly delays onset and attenuates the clinical course of experimental allergic encephalitis.

  6. Using mice lacking STIM1 (show STIM1 Proteins) and its homologue STIM2, authors find that store-operated calcium entry in CD8 (show CD8A Proteins)(+) T cells is required to prevent the engraftment of melanoma and colon carcinoma cells and to control tumour growth.

  7. STIM1 (show STIM1 Proteins) and STIM2-mediated store-operated Ca2 (show CA2 Proteins)+ influx, leading to efficient activation of NFAT (show NFATC1 Proteins) (nuclear factor of activated T cells), is critical for the postselection maturation of agonist-selected T cells.

  8. STIM1 (show STIM1 Proteins) and STIM2 protein deficiency in T lymphocytes underlies development of the exocrine gland autoimmune disease, Sjogren's syndrome.

  9. show that endoplasmic reticulum calcium sensors STIM1 (show STIM1 Proteins)- and STIM2-induced store-operated Ca(2 (show CA2 Proteins)+) influx is critical for B cell regulatory function

  10. Absence of STIM2 in mouse embryonic fibroblasts results in a decreased store-operated calcium ion entry, although this inhibition is less pronounced than for STIM1 (show STIM1 Proteins).

Stim2 Protein Profile

Protein Summary

This gene is a member of the stromal interaction molecule (STIM) family and likely arose, along with related family member STIM1, from a common ancestral gene. The encoded protein functions to regulate calcium concentrations in the cytosol and endoplasmic reticulum, and is involved in the activation of plasma membrane Orai Ca(2+) entry channels. This gene initiates translation from a non-AUG (UUG) start site. A signal peptide is cleaved from the resulting protein. Multiple transcript variants result from alternative splicing.

Gene names and symbols associated with Stim2

  • stromal interaction molecule 2 (STIM2)
  • stromal interaction molecule 2 (stim2)
  • stromal interaction molecule 2 (Stim2)
  • STIM2 protein

Protein level used designations for Stim2

stromal interaction molecule 2

GENE ID SPECIES
100083707 Ornithorhynchus anatinus
100471703 Ailuropoda melanoleuca
100566248 Anolis carolinensis
422799 Gallus gallus
461155 Pan troglodytes
541299 Bos taurus
694980 Macaca mulatta
733739 Xenopus (Silurana) tropicalis
100540015 Meleagris gallopavo
57620 Homo sapiens
116873 Mus musculus
117087 Rattus norvegicus
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