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SMC1L2 belongs to a family of proteins required for chromatid cohesion and DNA recombination during meiosis and mitosis (3:Revenkova et al., 2001 [PubMed 11564881]).[supplied by OMIM, Mar 2008].. Additionally we are shipping SMC1B Proteins (3) and many more products for this protein.
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High SMC1B expression is associated with pancreatic cancer.
Together with previous knowledge, three main functions of SMC1b have emerged, which have multiple consequences for spermatocyte biology.
We report here evidence from the mouse that partial loss of gene function for either Smc1b or Rec8 (show REC8 Antibodies) causes perturbations in the formation of the synaptonemal complex (SC) and affects both synapsis and recombination between homologs during meiotic prophase
SMC1 beta-deficient mice of both sexes are sterile. Male meiosis is blocked in pachytene; female meiosis is highly error-prone but continues until metaphase II.
E2F6 (show E2F6 Antibodies) silences SMC1beta and STAG3 (show STAG3 Antibodies) in somatic cells
SMC1beta plays role in oogenesis.
In addition to its role in sister chromatid cohesion, Smc1beta determines meiotic chromatin loop organization.
A deletion of 16 nucleotides in exon 5 led to a frame-shift, which generated a stop codon at position 761 (amino acid 247) of the Smc1b cDNA in mutant mice.
telomere structure protected from DNA rearrangements depends on SMC1beta.
SMC1L2 belongs to a family of proteins required for chromatid cohesion and DNA recombination during meiosis and mitosis (3:Revenkova et al., 2001
SMC protein 1B
, SMC1 (structural maintenance of chromosomes 1, yeast)-like 1
, SMC1 structural maintenance of chromosomes 1-like 2
, mitosis-specific chromosome segregation protein like protein beta
, structural maintenance of chromosomes protein 1B
, structural maintenace of chromosomes 1B