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anti-Structural Maintenance of Chromosomes 3 (SMC3) Antibodies

SMC3 belongs to the SMC3 subfamily of SMC proteins. Additionally we are shipping SMC3 Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SMC3 9126 Q9UQE7
SMC3 13006 Q9CW03
SMC3 29486  
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Top anti-SMC3 Antibodies at antibodies-online.com

Showing 10 out of 78 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated IHC, WB WB Suggested Anti-SMC3 Antibody Titration: 0.2-1 ug/mlPositive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-SMC3 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: COLO205 cell lysate WB Suggested Anti-SMC3  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.2500  Positive Control: COLO205 cell lysate  There is BioGPS gene expression data showing that SMC3 is expressed in COLO205 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), WB Anti- SMC3 Picoband antibody, IHC(P) IHC(P): Human Intestinal Cancer Tissue Anti- SMC3 Picoband antibody, IHC(P) IHC(P): Mouse Intestine Tissue 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated IHC (p), WB Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 8 to 10 Days
$676.50
Details
Cow Rabbit Un-conjugated WB Western blot analysis of HCAP (pS1083) expression in A549 (A), NS-1 (B), PC12 (C) whole cell lysates. 200 μL Log in to see 9 Days
$575.00
Details
Human Rabbit Un-conjugated IHC, ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Un-conjugated WB SMC3 antibody (pAb) tested by Western blot. Detection of SMC3 by Western blot analysis. Lane 1: Nuclear extract of HeLa cells (20 µg). Lane 2: Nuclear extract of Hep G2 cells (20 µg). Lane 3: Nuclear extract of HEK293 cells (20 µg). Lane 4: Nuclear extract of U2OS cells (20 µg). All were probed with SMC3 antibody (pAb) at a 1:500 dilution. 100 μL Log in to see 1 to 2 Days
$466.67
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated WB SMC3 Antibody (Center) (ABIN658756) western blot analysis in CEM cell line lysates (35 µg/lane). This demonstrates the SMC3 antibody detected the SMC3 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated ICC, IHC (fro), IHC (p), ELISA, WB 100 μg Log in to see 9 to 11 Days
$365.20
Details

SMC3 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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More Antibodies against SMC3 Interaction Partners

Human Structural Maintenance of Chromosomes 3 (SMC3) interaction partners

  1. De novo heterozygous mutations in SMC3 cause a range of Cornelia de Lange syndrome-overlapping phenotypes

  2. cohesin's proposed DNA exit gate is formed by interactions between Scc1 (show PTPRJ Antibodies) and the coiled-coil region of Smc3.

  3. Cross-sectional deep-sequencing analysis for clonal hierarchy demonstrated STAG2 (show STAG2 Antibodies), SMC3, and RAD21 (show RAD21 Antibodies) mutations to be ancestral in 18%, 18%, and 47% of cases, respectively, and each expanded to clonal dominance concordant with disease transformation

  4. Mutations in SMC3 is associated with acute myeloid leukemia (show BCL11A Antibodies).

  5. Upon knock-down of human SMC1, much of SMC3 remains stable, accumulates in the cytoplasm and does not associate with other cohesin proteins.

  6. c-MYC (show MYC Antibodies) down-regulation caused by cohesin mutations in SMC1A (show SMC1A Antibodies) and SMC3 genes may be an early/primary event in the pathogenesis of Cornelia de Lange syndrome.

  7. NIPBL (show NIPBL Antibodies), SMC1A (show SMC1A Antibodies), and SMC3 mutation-positive patients were equally likely to have congenital heart diseases in Cornelia de lange syndrome.

  8. SMC3 and separase (show ESPL1 Antibodies) are upregulated and securin (show PTTG1 Antibodies) is downregulated in malignant transformation of BEAS-2B cells induced by coal tar (show RBM8A Antibodies) pitch smoke extracts.

  9. these studies clearly suggest that bamacan interacts with the vaccinia virus-N1L and such interactions seem to play a positive role in promoting the viral growth and perhaps contribute to the virulence of VV in neural cells.

  10. The identification of 14 additional mutations of the cohesin complex genes NIPBL (show NIPBL Antibodies) and SMC1A (show SMC1A Antibodies) in a cohort of 30 unrelated patients with Cornelia de Lange syndrome, is reported.

Mouse (Murine) Structural Maintenance of Chromosomes 3 (SMC3) interaction partners

  1. A positively charged channel within the Smc1 (show SMC1A Antibodies)/Smc3 hinge required for sister chromatid cohesion.

Xenopus laevis Structural Maintenance of Chromosomes 3 (SMC3) interaction partners

  1. XEco2 (show ESCO2 Antibodies) is the cohesin acetyltransferase responsible for Smc3 acetylation.

  2. Endogenous SMC3 and newly expressed hRAD21 (show RAD21 Antibodies) co-localize on chromosomal axes, sites where sister chromatids are tightly paired. hRAD21 (show RAD21 Antibodies) recruitment to lampbrush chromosomes is modulated by chromosomal SMC1 (show SMC1A Antibodies) and SMC3.

SMC3 Antigen Profile

Protein Summary

This gene belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenance of chromosomes 3, is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis, enabling proper chromosome segregation. Post-translational modification of the encoded protein by the addition of chondroitin sulfate chains gives rise to the secreted proteoglycan bamacan, an abundant basement membrane protein.

Gene names and symbols associated with SMC3

  • structural maintenance of chromosomes 3 (smc3) antibody
  • structural maintenance of chromosomes 3 (SMC3) antibody
  • structural maintenance of chromosomes 3 (Smc3) antibody
  • BAM antibody
  • bamacan antibody
  • BMH antibody
  • CDLS3 antibody
  • Cspg6 antibody
  • HCAP antibody
  • im:7142991 antibody
  • Mmip1 antibody
  • SMC-3 antibody
  • SMC3L1 antibody
  • SmcD antibody
  • wu:fb22e01 antibody
  • wu:fc30d07 antibody
  • xsmc3 antibody

Protein level used designations for SMC3

chondroitin sulfate proteoglycan 6 (bamacan) , SMC protein 3 , basement membrane-associated chondroitin proteoglycan , chromosome-associated polypeptide , structural maintenance of chromosomes protein 3 , chondroitin sulfate proteoglycan 6 , chromosome segregation protein SmcD , mad member-interacting protein 1 , structural maintenace of chromosomes 3 , cohesin complex subunit , bamacan , basement membrane chondroitin sulfate proteoglycan

GENE ID SPECIES
100145671 Xenopus (Silurana) tropicalis
9126 Homo sapiens
13006 Mus musculus
324475 Danio rerio
399092 Xenopus laevis
395188 Gallus gallus
486886 Canis lupus familiaris
281729 Bos taurus
29486 Rattus norvegicus
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