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SMC3 belongs to the SMC3 subfamily of SMC proteins. Additionally we are shipping SMC3 Proteins (6) and many more products for this protein.
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De novo heterozygous mutations in SMC3 cause a range of Cornelia de Lange syndrome-overlapping phenotypes
cohesin's proposed DNA exit gate is formed by interactions between Scc1 (show PTPRJ Antibodies) and the coiled-coil region of Smc3.
Cross-sectional deep-sequencing analysis for clonal hierarchy demonstrated STAG2 (show STAG2 Antibodies), SMC3, and RAD21 (show RAD21 Antibodies) mutations to be ancestral in 18%, 18%, and 47% of cases, respectively, and each expanded to clonal dominance concordant with disease transformation
Mutations in SMC3 is associated with acute myeloid leukemia (show BCL11A Antibodies).
Upon knock-down of human SMC1, much of SMC3 remains stable, accumulates in the cytoplasm and does not associate with other cohesin proteins.
c-MYC (show MYC Antibodies) down-regulation caused by cohesin mutations in SMC1A (show SMC1A Antibodies) and SMC3 genes may be an early/primary event in the pathogenesis of Cornelia de Lange syndrome.
NIPBL (show NIPBL Antibodies), SMC1A (show SMC1A Antibodies), and SMC3 mutation-positive patients were equally likely to have congenital heart diseases in Cornelia de lange syndrome.
SMC3 and separase (show ESPL1 Antibodies) are upregulated and securin (show PTTG1 Antibodies) is downregulated in malignant transformation of BEAS-2B cells induced by coal tar (show RBM8A Antibodies) pitch smoke extracts.
these studies clearly suggest that bamacan interacts with the vaccinia virus-N1L and such interactions seem to play a positive role in promoting the viral growth and perhaps contribute to the virulence of VV in neural cells.
The identification of 14 additional mutations of the cohesin complex genes NIPBL (show NIPBL Antibodies) and SMC1A (show SMC1A Antibodies) in a cohort of 30 unrelated patients with Cornelia de Lange syndrome, is reported.
A positively charged channel within the Smc1 (show SMC1A Antibodies)/Smc3 hinge required for sister chromatid cohesion.
XEco2 (show ESCO2 Antibodies) is the cohesin acetyltransferase responsible for Smc3 acetylation.
Endogenous SMC3 and newly expressed hRAD21 (show RAD21 Antibodies) co-localize on chromosomal axes, sites where sister chromatids are tightly paired. hRAD21 (show RAD21 Antibodies) recruitment to lampbrush chromosomes is modulated by chromosomal SMC1 (show SMC1A Antibodies) and SMC3.
This gene belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenance of chromosomes 3, is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis, enabling proper chromosome segregation. Post-translational modification of the encoded protein by the addition of chondroitin sulfate chains gives rise to the secreted proteoglycan bamacan, an abundant basement membrane protein.
chondroitin sulfate proteoglycan 6 (bamacan)
, SMC protein 3
, basement membrane-associated chondroitin proteoglycan
, chromosome-associated polypeptide
, structural maintenance of chromosomes protein 3
, chondroitin sulfate proteoglycan 6
, chromosome segregation protein SmcD
, mad member-interacting protein 1
, structural maintenace of chromosomes 3
, cohesin complex subunit
, basement membrane chondroitin sulfate proteoglycan