Succinate Dehydrogenase Complex, Subunit A, Flavoprotein (Fp) Proteins (SDHA)

SDHA encodes a major catalytic subunit of succinate-ubiquinone oxidoreductase, a complex of the mitochondrial respiratory chain. Additionally we are shipping Succinate Dehydrogenase Complex, Subunit A, Flavoprotein (Fp) Antibodies (95) and Succinate Dehydrogenase Complex, Subunit A, Flavoprotein (Fp) Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SDHA 6389 P31040
SDHA 66945 Q8K2B3
SDHA 157074 Q920L2
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Top Succinate Dehydrogenase Complex, Subunit A, Flavoprotein (Fp) Proteins at antibodies-online.com

Showing 6 out of 17 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
HOST_Escherichia coli (E. coli) Human GST tag Succinate Dehydrogenase Complex, Subunit A, Flavoprotein (Fp) (SDHA) (AA 44-293), (partial) protein (GST tag) 1 mg Log in to see 60 to 71 Days
$3,685.00
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HOST_Escherichia coli (E. coli) Human GST tag   50 μg Log in to see 11 Days
$341.00
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Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,793.17
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HOST_Escherichia coli (E. coli) Mouse T7 tag,His tag   100 μg Log in to see 15 to 18 Days
$701.00
Details

SDHA Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
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Mouse (Murine) ,
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Rat (Rattus)

More Proteins for Succinate Dehydrogenase Complex, Subunit A, Flavoprotein (Fp) (SDHA) Interaction Partners

Human Succinate Dehydrogenase Complex, Subunit A, Flavoprotein (Fp) (SDHA) interaction partners

  1. SDH-deficient gastrointestinal stromal tumors (GISTs) account for approximately 8% of gastric GISTs and are associated with a high rate of distant metastasis, regardless of conventional risk category.

  2. For classification, tumors were characterized by SDHA, B, C, or D (SDHX) mutations and other genetic and epigenetic alterations, including presence of mutations in germline

  3. data show that SDHA flavination is independent of SDHAF2 (show Sdhaf2 Proteins) in breast cancer cells, employing an alternative mechanism.

  4. FAD (show BRCA2 Proteins) interacts noncovalently with SDHA in the absence of SDH5 (show Sdhaf2 Proteins)

  5. After indirect co-culture, OP was increased in the BxPc-3 and Panc-1 cells; correspondingly, succinate dehydrogenase, FH and MCT (show MCAT Proteins) expression were increased. After the MCT1 (show CMA1 Proteins)-specific inhibitor removed 'tumor-stromal' metabolic coupling, the migration and invasion abilities of the pancreatic cancer cells were decreased.

  6. Data suggest that succinate dehydrogenases SDHA and SDHB (show SDHB Proteins) immunohistochemistry should be interpreted with caution, due to possible false-positive or false-negative results, and ideally in the setting of quality assurance provided by molecular testing.

  7. Combined blockade of CDK (show CDK4 Proteins) and SDH, both genetically and pharmaceutically, showed synergy and resulted in inhibited proliferation, migration, invasion and migration in A2780 cells Cyclin E (show CCNE1 Proteins)-driven OvCa cells appeared addicted to glucose metabolism via TCA. Combined CDKi (show CDKN1C Proteins) with modalities targeting TCA, like SDHA inhibition showed promising effects for this genotype.

  8. According to international guidelines, SDHB (show SDHB Proteins), SDHC (show SDHC Proteins), and SDHD (show SDHD Proteins) genetic testing were performed in this patient, but not SDHA, which would have been prescribed only after surgery, in case of SDHA negative immunohistochemistry

  9. As a similar defect of succinate dehydrogenase is apparent in patient cell-derived cardiomyocytes, the authors conclude that these defects represent a molecular basis for the cardiac pathology in Barth syndrome (show TAZ Proteins).

  10. our findings provide further evidence that patients with KIT/PDGFRA (show PDGFRA Proteins) wild-type SDH-deficient GIST harboring SDHA mutations experience good survival outcomes

Mouse (Murine) Succinate Dehydrogenase Complex, Subunit A, Flavoprotein (Fp) (SDHA) interaction partners

  1. Tumor-derived FH and SDH (show SDS Proteins) mutations accumulate fumarate and succinate, leading to enzymatic inhibition of multiple alpha-KG-dependent dioxygenases and consequent alterations of genome-wide histone and DNA methylation (show HELLS Proteins).

  2. Data show that SdhA is required for preventing AIM2 (show AIM2 Proteins) inflammasome activation.

  3. Data show that two subunits of complex II (succinate dehydrogenase (show SDHD Proteins), or SDH (show SDS Proteins)), SDHA and SDHB (show SDHB Proteins), interacted specifically with SIRT3 (show SIRT3 Proteins).

  4. Cocaine could inhibit the activities of ATPase, LDH and SDH (show SDS Proteins) in cultured splenocytes.

Succinate Dehydrogenase Complex, Subunit A, Flavoprotein (Fp) (SDHA) Protein Profile

Protein Summary

This gene encodes a major catalytic subunit of succinate-ubiquinone oxidoreductase, a complex of the mitochondrial respiratory chain. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. Mutations in this gene have been associated with a form of mitochondrial respiratory chain deficiency known as Leigh Syndrome. A pseudogene has been identified on chromosome 3q29.

Gene names and symbols associated with SDHA

  • Succinate dehydrogenase A (SdhA)
  • succinate dehydrogenase complex, subunit A, flavoprotein (Fp) (SDHA)
  • succinate dehydrogenase complex, subunit A, flavoprotein (Fp) (Sdha)
  • succinate dehydrogenase complex, subunit A, flavoprotein (Fp) (sdha)
  • 1500032O14Rik protein
  • 2310034D06Rik protein
  • 4921513A11 protein
  • C81073 protein
  • CG17246 protein
  • CMD1GG protein
  • Dmel\\CG17246 protein
  • Fp protein
  • im:7141001 protein
  • PGL5 protein
  • scs-fp protein
  • sdh protein
  • SDH1 protein
  • SDH2 protein
  • Sdha protein
  • sdha-b protein
  • SDHF protein
  • zgc:56051 protein

Protein level used designations for SDHA

CG17246-PA , CG17246-PB , CG17246-PC , COMPLEX II: flavoprotein subunit , SUCCINYL COENZIME A SYNTHETASE FLAVOPROTEIN SUBUNIT , SdhA-PA , SdhA-PB , SdhA-PC , succinate dehydrogenase , succinate dehydrogenase A , succinate dehydrogenase flavoprotein , succinate dehydrogenase flavoprotein subunit , succinyl coenzyme A synthetase flavoprotein subunit , flavoprotein subunit of complex II , succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial , succinate dehydrogenase complex flavoprotein subunit , fp , succinate dehydrogenase complex subunit A , succinate dehydrogenase flavoprotein subunit A , succinate dehydrogenase Fp subunit , Flavoprotein subunit of complex II , Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial , mitochondrial succinate dehydrogenase complex subunit A , succinate dehydrogenase complex subunit A flavoprotein , flavoprotein subunit of complex II B , succinate dehydrogenase [ubiquinone] flavoprotein subunit B, mitochondrial

GENE ID SPECIES
37228 Drosophila melanogaster
6389 Homo sapiens
66945 Mus musculus
157074 Rattus norvegicus
393884 Danio rerio
281480 Bos taurus
395758 Gallus gallus
780433 Sus scrofa
380463 Xenopus laevis
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