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Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) Proteins (SDHB)

Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. Additionally we are shipping Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) Antibodies (94) and Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SDHB 6390 P21912
SDHB 67680 Q9CQA3
SDHB 298596 P21913
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Top Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) Proteins at antibodies-online.com

Showing 10 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Schizosaccharomyces pombe His tag   1 mg Log in to see 56 to 66 Days
$2,643.67
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Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,647.33
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Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$2,647.33
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,647.33
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Yeast Zebrafish His tag   1 mg Log in to see 56 to 66 Days
$2,656.50
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Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$2,660.17
Details
Yeast Xenopus tropicalis His tag   1 mg Log in to see 56 to 66 Days
$2,665.67
Details

SDHB Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) (SDHB) Interaction Partners

Fruit Fly (Drosophila melanogaster) Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) (SDHB) interaction partners

  1. sdhB mutant is hypersensitive to oxygen and displays hallmarks of a progeroid syndrome

Human Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) (SDHB) interaction partners

  1. The low penetrance of SDHB mutations may obscure the hereditary nature of SDHB-linked disease and is important in the counseling of SDHB-linked patients.

  2. Succinate dehydrogenase (show SDHA Proteins) deficiency is a rare leukoencephalopathy, for which improved recognition by magnetic resonance imaging (MRI (show C7ORF49 Proteins)) in combination with advanced sequencing technologies allows noninvasive diagnostic confirmation.

  3. 15 YEARS OF PARAGANGLIOMA: Genetics and mechanism of pheochromocytoma-paraganglioma syndromes characterized by germline SDHB and SDHD (show SDHD Proteins) mutations

  4. Study reveals new insights into the effects of SDHB mutations and the power of structural modelling in predicting biological consequences.

  5. for the first time, we show a high correlation between urinary bladder paragangliomas and SDHB mutations

  6. Findings provide a conceptual framework for understanding how particular mutations disproportionately cause the loss of SDH activity, resulting in accumulation of succinate and metabolic remodeling in SDHB cancer syndromes.

  7. Germline mutation in the SDHB gene is the only reliable predictor of malignant Paragangliomas.

  8. Report direct correlation between the presence of an SDHB mutation, whether germline or somatic, and negative SDHB immunohistochemical staining in bladder paragangliomas.

  9. This study strengthens the etiological association of SDH genes with pituitary neoplasia, renal tumorigenesis, and gastric gastrointestinal stromal tumors. Also, pancreatic neuroendocrine tumor falls within the SDH-related tumor spectrum.

  10. SDHB immunohistochemistry alone may be misleading in excluding tumors other than gastrointestinal stromal tumors

Pig (Porcine) Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) (SDHB) interaction partners

  1. tissue expression analysis indicated that that swine SDHB, SNRPA (show SNRPA Proteins) and CRYBB1 (show CRYBB1 Proteins) gene were differentially expressed in tissues including fat, lung, muscle, small intestine, kidney, large intestine, spleen and liver

Mouse (Murine) Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) (SDHB) interaction partners

  1. Data show that lack of succinate dehydrogenase (SDH (show SDHA Proteins)) activity commits cells to consume extracellular pyruvate.

  2. Using Sdhb(+/-) mice, we provide evidence that pituitary hyperplasia in SDHx-deficient cells may be the initial abnormality in the cascade of events leading to pituitary adenoma formation.

  3. Tumor-derived FH and SDH (show SDS Proteins) mutations accumulate fumarate and succinate, leading to enzymatic inhibition of multiple alpha-KG-dependent dioxygenases and consequent alterations of genome-wide histone and DNA methylation (show HELLS Proteins).

  4. Data show that two subunits of complex II (succinate dehydrogenase (show SDHD Proteins), or SDH (show SDS Proteins)), SDHA (show SDHA Proteins) and SDHB, interacted specifically with SIRT3 (show SIRT3 Proteins).

Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) (SDHB) Protein Profile

Protein Summary

Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis.

Gene names and symbols associated with SDHB

  • succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (SDHB)
  • succinate dehydrogenase [ubiquinone] iron-sulfur subunit 3 (SDH2-3)
  • Succinate dehydrogenase B (SdhB)
  • succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (sdhb)
  • succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (Sdhb)
  • 0710008N11Rik protein
  • CG3283 protein
  • CWS2 protein
  • Dmel\\CG3283 protein
  • fj46d06 protein
  • IP protein
  • PGL4 protein
  • SDH protein
  • SDH-Ip protein
  • SDH1 protein
  • SDH2 protein
  • sdhB protein
  • SDHIP protein
  • succinate dehydrogenase 2-3 protein
  • wu:fj46d06 protein

Protein level used designations for SDHB

succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial , succinate dehydrogenase complex subunit B , CG3283-PA , COMPLEX II: iron-sulfur subunit , SdhB-PA , iron-sulfur protein subunit of succinate dehydrogenase , succinate dehydrogenase , succinate dehydrogenase B , succinate dehydrogenase Iron-sulfur , succinate dehydrogenase Iron-sulfur protein , succinate dehydrogenase iron protein , succinate dehydrogenase subunit b , iron-sulfur subunit of complex II , Iron-sulfur subunit of complex II , IP , ip

GENE ID SPECIES
100050091 Equus caballus
770063 Arabidopsis thaliana
35590 Drosophila melanogaster
100144957 Xenopus (Silurana) tropicalis
6390 Homo sapiens
478217 Canis lupus familiaris
414412 Sus scrofa
286840 Bos taurus
100328585 Oryctolagus cuniculus
67680 Mus musculus
298596 Rattus norvegicus
562149 Danio rerio
379939 Xenopus laevis
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