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SDHC encodes one of four nuclear-encoded subunits that comprise succinate dehydrogenase, also known as mitochondrial complex II, a key enzyme complex of the tricarboxylic acid cycle and aerobic respiratory chains of mitochondria. Additionally we are shipping SDHC Kits (4) and SDHC Proteins (3) and many more products for this protein.
Showing 10 out of 44 products:
Human Monoclonal SDHC Primary Antibody for ELISA, WB - ABIN520106
Lemarie, Grimm: Mutations in the heme b-binding residue of SDHC inhibit assembly of respiratory chain complex II in mammalian cells. in Mitochondrion 2009
Show all 2 references for ABIN520106
Studies indicate that the Tet-mev-1 conditional transgenic system can induce mutated SDHC gene in complex II.
Loss of the SDHC gene is associated with metastatic sympathetic paraganglioma.
This report provides evidence that SDHC promoter methylation can cause Paragangliomas due to SDHC inactivation
significant association with overall survival were confirmed for SDHC gene, SDHD (show SDHD Antibodies) gene and FH gene ... SDHC gene and FH gene were the primary factors contributing to the different overall survival time of colorectal carcinoma
This study strengthens the etiological association of SDH (show SARDH Antibodies) genes with pituitary neoplasia, renal tumorigenesis, and gastric gastrointestinal stromal tumors. Also, pancreatic neuroendocrine tumor falls within the SDH (show SARDH Antibodies)-related tumor spectrum.
The discovery of SDHC epimutation provides a unifying explanation for the pathogenesis of SDH (show SARDH Antibodies)-deficient gastrointestinal stromal tumors.
Variant in rs3935401 in the 3' untranslated region of SDHC is associated with hepatocellular carcinoma.
these data suggest epigenetic inactivation of the SDHC gene locus with functional impairment of the SDHC as a plausible alternate mechanism of tumorigenesis in Carney Triad
Overall, 9 of the 34 patients with KIT/PDGFRA (show PDGFRA Antibodies) wild-type GIST carried mutations in one of the four subunits of the SDH (show SARDH Antibodies) complex (six patients in SDHA (show SDHA Antibodies), two in SDHB (show SDHB Antibodies), one in SDHC
Thoracic paragangliomas are common in patients with SDHC mutations, and imaging of this area should be included in surveillance of mutation carriers.
SDH (show SARDH Antibodies) deficiency may promote tumorigenesis through accumulation of succinate and inhibition of dioxygenase enzymes. Inhibition of TET activity may, in turn, alter global DNA methylation (show HELLS Antibodies) and gene expression in SDH (show SARDH Antibodies)-deficient tumors.
This gene encodes one of four nuclear-encoded subunits that comprise succinate dehydrogenase, also known as mitochondrial complex II, a key enzyme complex of the tricarboxylic acid cycle and aerobic respiratory chains of mitochondria. The encoded protein is one of two integral membrane proteins that anchor other subunits of the complex, which form the catalytic core, to the inner mitochondrial membrane. Several related pseudogenes are located in different genomic regions. Mutations in this gene have been associated with paragangliomas. Alternatively spliced transcript variants encoding different isoforms have been described.
succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
, ENSANGP00000017418-like protein
, OXPHOS complex II cytochrome B560 subunit
, succinate dehydrogenase C
, succinate dehydrogenase cytochrome b560 subunit, mitochondrial
, integral membrane protein CII-3
, succinate dehydrogenase complex, subunit C
, cytochrome B large subunit of complex II
, integral membrane protein CII-3b
, succinate dehydrgenase cytochrome b
, succinate dehydrogenase 3, integral membrane subunit
, succinate-ubiquinone oxidoreductase cytochrome B large subunit
, succinate dehydrogenase complex subunit C